FLOT1 — 41 ClinVar variants
All ClinVar germline FLOT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
41 Uncertain significance
Full FLOT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FLOT1 p.Ala212Ser Uncertain significance Single submitter
- FLOT1 p.Ala234Ser Uncertain significance Single submitter
- FLOT1 p.Ala324Thr Uncertain significance Single submitter
- FLOT1 p.Ala84Thr Uncertain significance Single submitter
- FLOT1 p.Ala94Val Uncertain significance Single submitter
- FLOT1 p.Arg177Gln Uncertain significance Single submitter
- FLOT1 p.Arg185Lys Uncertain significance Single submitter
- FLOT1 p.Arg190Gln Uncertain significance Single submitter
- FLOT1 p.Arg230His Uncertain significance Single submitter
- FLOT1 p.Arg231Gln Uncertain significance Single submitter
- FLOT1 p.Arg332Leu Uncertain significance Single submitter
- FLOT1 p.Arg58His Uncertain significance Single submitter
- FLOT1 p.Cys34Arg Uncertain significance Single submitter
- FLOT1 p.Gln349Leu Uncertain significance Single submitter
- FLOT1 p.Glu226Lys Uncertain significance Single submitter
- FLOT1 p.Glu350Asp Uncertain significance Single submitter
- FLOT1 p.Glu350Lys Uncertain significance Single submitter
- FLOT1 p.Glu53Ala Uncertain significance Single submitter
- FLOT1 p.Gly384Ser Uncertain significance Single submitter
- FLOT1 p.Gly60Val Uncertain significance Single submitter
- FLOT1 p.Lys422Gln Uncertain significance Single submitter
- FLOT1 p.Met142Val Uncertain significance Single submitter
- FLOT1 p.Met23Arg Uncertain significance Single submitter
- FLOT1 p.Phe88Leu Uncertain significance Single submitter
- FLOT1 p.Ser407Cys Uncertain significance Single submitter
- FLOT1 p.Ser415Gly Uncertain significance Single submitter
- FLOT1 p.Thr66Ile Uncertain significance Single submitter
- FLOT1 p.Val419Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- FLOT1 p.Arg317Gly Uncertain significance Single submitter
- FLOT1 p.Glu288Lys Uncertain significance Single submitter
- FLOT1 p.Glu295Lys Uncertain significance Single submitter
- FLOT1 p.Glu301Asp Uncertain significance Single submitter
- FLOT1 p.Glu310Lys Uncertain significance Single submitter
- FLOT1 p.Ile400Thr Uncertain significance Single submitter
- FLOT1 p.Thr92Met Uncertain significance Single submitter
- FLOT1 p.Tyr223Cys Uncertain significance Single submitter
- FLOT1 p.Val259Met Uncertain significance Single submitter
All FLOT1 variants
Uncertain significance 41
- p.Ala212Ser Single submitter ⚠
- p.Ala234Ser Single submitter ⚠
- p.Ala298Val Single submitter
- p.Ala324Thr Single submitter ⚠
- p.Ala84Thr Single submitter ⚠
- p.Ala94Val Single submitter ⚠
- p.Arg177Gln Single submitter ⚠
- p.Arg177Trp Single submitter
- p.Arg185Lys Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg230His Single submitter ⚠
- p.Arg231Gln Single submitter ⚠
- p.Arg317Gly Single submitter ⚠
- p.Arg332Leu Single submitter ⚠
- p.Arg58His Single submitter ⚠
- p.Cys17Tyr Single submitter
- p.Cys34Arg Single submitter ⚠
- p.Gln349Leu Single submitter ⚠
- p.Glu226Lys Single submitter ⚠
- p.Glu288Lys Single submitter ⚠
- p.Glu295Lys Single submitter ⚠
- p.Glu301Asp Single submitter ⚠
- p.Glu310Lys Single submitter ⚠
- p.Glu350Asp Single submitter ⚠
- p.Glu350Lys Single submitter ⚠
- p.Glu53Ala Single submitter ⚠
- p.Gly384Ser Single submitter ⚠
- p.Gly60Val Single submitter ⚠
- p.Ile400Thr Single submitter ⚠
- p.Lys422Gln Single submitter ⚠
- p.Met142Val Single submitter ⚠
- p.Met23Arg Single submitter ⚠
- p.Phe88Leu Single submitter ⚠
- p.Ser407Cys Single submitter ⚠
- p.Ser415Gly Single submitter ⚠
- p.Thr66Ile Single submitter ⚠
- p.Thr92Met Single submitter ⚠
- p.Tyr223Cys Single submitter ⚠
- p.Val259Met Single submitter ⚠
- p.Val414Glu Single submitter
- p.Val419Leu Single submitter ⚠