FOLH1 — 75 ClinVar variants
All ClinVar germline FOLH1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
4 Benign · 9 Likely benign · 62 Uncertain significance
Full FOLH1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FOLH1 p.Ala313Val Uncertain significance Single submitter
- FOLH1 p.Ala601Ser Uncertain significance Single submitter
- FOLH1 p.Arg190Gln Uncertain significance Single submitter
- FOLH1 p.Arg255His Uncertain significance Single submitter
- FOLH1 p.Arg281Ser Uncertain significance Single submitter
- FOLH1 p.Arg363Ile Uncertain significance Single submitter
- FOLH1 p.Arg527Gln Uncertain significance Single submitter
- FOLH1 p.Arg536Gln Uncertain significance Single submitter
- FOLH1 p.Asn140Ser Uncertain significance Single submitter
- FOLH1 p.Asp156Asn Uncertain significance Single submitter
- FOLH1 p.Gln620Lys Uncertain significance Single submitter
- FOLH1 p.Glu480Gln Uncertain significance Single submitter
- FOLH1 p.Glu486Asp Uncertain significance Single submitter
- FOLH1 p.Glu703Lys Uncertain significance Single submitter
- FOLH1 p.Gly224Glu Uncertain significance Single submitter
- FOLH1 p.Gly24Trp Uncertain significance Single submitter
- FOLH1 p.Gly250Arg Uncertain significance Single submitter
- FOLH1 p.Gly30Ser Uncertain significance Single submitter
- FOLH1 p.Gly430Asp Uncertain significance Single submitter
- FOLH1 p.Gly490Asp Uncertain significance Single submitter
- FOLH1 p.Gly533Asp Uncertain significance Single submitter
- FOLH1 p.Gly726Arg Uncertain significance Single submitter
- FOLH1 p.His6Gln Uncertain significance Single submitter
- FOLH1 p.Leu219Met Uncertain significance Single submitter
- FOLH1 p.Leu574Ile Uncertain significance Single submitter
- FOLH1 p.Leu65Met Uncertain significance Single submitter
- FOLH1 p.Lys223Arg Uncertain significance Single submitter
- FOLH1 p.Lys240Thr Uncertain significance Single submitter
- FOLH1 p.Lys304Asn Uncertain significance Single submitter
- FOLH1 p.Lys94Arg Uncertain significance Single submitter
- FOLH1 p.Met622Val Uncertain significance Single submitter
- FOLH1 p.Phe546Cys Uncertain significance Single submitter
- FOLH1 p.Phe90Val Uncertain significance Single submitter
- FOLH1 p.Pro273Ala Uncertain significance Single submitter
- FOLH1 p.Pro550Ala Uncertain significance Single submitter
- FOLH1 p.Pro685Thr Uncertain significance Single submitter
- FOLH1 p.Ser317Gly Uncertain significance Single submitter
- FOLH1 p.Ser401Gly Uncertain significance Single submitter
- FOLH1 p.Ser644Tyr Uncertain significance Single submitter
- FOLH1 p.Ser695Asn Uncertain significance Single submitter
- FOLH1 p.Ser722Pro Uncertain significance Single submitter
- FOLH1 p.Thr624Ser Uncertain significance Single submitter
- FOLH1 p.Tyr300Asn Uncertain significance Single submitter
- FOLH1 p.Tyr300His Uncertain significance Single submitter
- FOLH1 p.Tyr537His Uncertain significance Single submitter
- FOLH1 p.Tyr559Asn Uncertain significance Single submitter
- FOLH1 p.Tyr572Cys Uncertain significance Single submitter
- FOLH1 p.Val12Ala Uncertain significance Single submitter
- FOLH1 p.Val154Ile Uncertain significance Single submitter
- FOLH1 p.Val239Met Uncertain significance Single submitter
- FOLH1 p.Val562Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- FOLH1 p.Gly288Val Uncertain significance Single submitter
- FOLH1 p.Leu38Arg Uncertain significance Single submitter
- FOLH1 p.Leu587Val Uncertain significance Single submitter
- FOLH1 p.Lys407Glu Uncertain significance Single submitter
- FOLH1 p.Phe524Ser Uncertain significance Single submitter
- FOLH1 p.Pro159Leu Uncertain significance Single submitter
All FOLH1 variants
Benign 4
- p.Gly172= Multiple submitters
- p.Pro160Ala Multiple submitters
- p.Ser155Leu Multiple submitters
- p.Tyr75His Multiple submitters
Likely benign 9
- p.Asp244= Multiple submitters
- p.Arg511= Single submitter
- p.Glu748= Single submitter
- p.Gly548Ser Single submitter
- p.Ile157Val Single submitter
- p.Leu268Phe Single submitter
- p.Ser717Asn Single submitter
- p.Thr334Ala Single submitter
- p.Tyr179= Single submitter
Uncertain significance 62
- p.Ala313Val Single submitter ⚠
- p.Ala601Ser Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg255His Single submitter ⚠
- p.Arg281Ser Single submitter ⚠
- p.Arg363Ile Single submitter ⚠
- p.Arg378Gln Single submitter
- p.Arg527Gln Single submitter ⚠
- p.Arg536Gln Single submitter ⚠
- p.Arg536Trp Single submitter
- p.Asn140Ser Single submitter ⚠
- p.Asp156Asn Single submitter ⚠
- p.Gln620Lys Single submitter ⚠
- p.Glu480Gln Single submitter ⚠
- p.Glu486Asp Single submitter ⚠
- p.Glu703Lys Single submitter ⚠
- p.Gly224Glu Single submitter ⚠
- p.Gly24Trp Single submitter ⚠
- p.Gly250Arg Single submitter ⚠
- p.Gly288Val Single submitter ⚠
- p.Gly30Ser Single submitter ⚠
- p.Gly430Asp Single submitter ⚠
- p.Gly490Asp Single submitter ⚠
- p.Gly533Asp Single submitter ⚠
- p.Gly726Arg Single submitter ⚠
- p.His6Gln Single submitter ⚠
- p.Leu219Met Single submitter ⚠
- p.Leu38Arg Single submitter ⚠
- p.Leu574Ile Single submitter ⚠
- p.Leu587Val Single submitter ⚠
- p.Leu65Met Single submitter ⚠
- p.Leu74Phe Single submitter
- p.Lys223Arg Single submitter ⚠
- p.Lys240Thr Single submitter ⚠
- p.Lys304Asn Single submitter ⚠
- p.Lys407Glu Single submitter ⚠
- p.Lys94Arg Single submitter ⚠
- p.Met622Val Single submitter ⚠
- p.Phe524Ser Single submitter ⚠
- p.Phe546Cys Single submitter ⚠
- p.Phe713Ile Single submitter
- p.Phe90Val Single submitter ⚠
- p.Pro159Leu Single submitter ⚠
- p.Pro273Ala Single submitter ⚠
- p.Pro550Ala Single submitter ⚠
- p.Pro685Thr Single submitter ⚠
- p.Ser317Gly Single submitter ⚠
- p.Ser401Gly Single submitter ⚠
- p.Ser644Tyr Single submitter ⚠
- p.Ser695Asn Single submitter ⚠
- p.Ser722Pro Single submitter ⚠
- p.Thr624Ser Single submitter ⚠
- p.Tyr300Asn Single submitter ⚠
- p.Tyr300His Single submitter ⚠
- p.Tyr537His Single submitter ⚠
- p.Tyr559Asn Single submitter ⚠
- p.Tyr572Cys Single submitter ⚠
- p.Val12Ala Single submitter ⚠
- p.Val154Ile Single submitter ⚠
- p.Val239Met Single submitter ⚠
- p.Val447Met Single submitter
- p.Val562Met Single submitter ⚠