Sugi Variant

Sugi Variant/FOXG1

FOXG1 — 850 ClinVar variants

All ClinVar germline FOXG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 254 flagged for review →

139 Pathogenic · 27 Pathogenic/Likely pathogenic · 80 Likely pathogenic · 27 Conflicting · 60 Benign · 13 Benign/Likely benign · 224 Likely benign · 280 Uncertain significance

Full FOXG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 254

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 13

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 156

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 156

Predictors split 84

The independent predictors disagree with each other — read with care.

All FOXG1 variants

Pathogenic 139

Pathogenic/Likely pathogenic 27

Likely pathogenic 80

Conflicting classifications of pathogenicity 27

Benign 60

Benign/Likely benign 13

Likely benign 224

Uncertain significance 280