FPR2 — 46 ClinVar variants
All ClinVar germline FPR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
1 Benign/Likely benign · 3 Likely benign · 42 Uncertain significance
Full FPR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FPR2 p.Ala245Val Uncertain significance Single submitter
- FPR2 p.Ala248Ser Uncertain significance Single submitter
- FPR2 p.Arg57His Uncertain significance Single submitter
- FPR2 p.Cys296Trp Uncertain significance Single submitter
- FPR2 p.Cys98Arg Uncertain significance Single submitter
- FPR2 p.Glu311Asp Uncertain significance Single submitter
- FPR2 p.Gly40Arg Uncertain significance Single submitter
- FPR2 p.His136Tyr Uncertain significance Single submitter
- FPR2 p.His315Tyr Uncertain significance Single submitter
- FPR2 p.Ile116Val Uncertain significance Single submitter
- FPR2 p.Ile27Leu Uncertain significance Single submitter
- FPR2 p.Leu128Arg Uncertain significance Single submitter
- FPR2 p.Leu272Phe Uncertain significance Single submitter
- FPR2 p.Lys227Asn Uncertain significance Single submitter
- FPR2 p.Met197Ile Uncertain significance Single submitter
- FPR2 p.Met197Val Uncertain significance Single submitter
- FPR2 p.Met85Thr Uncertain significance Single submitter
- FPR2 p.Pro213Leu Uncertain significance Single submitter
- FPR2 p.Pro299Arg Uncertain significance Single submitter
- FPR2 p.Pro8Thr Uncertain significance Single submitter
- FPR2 p.Ser112Asn Uncertain significance Single submitter
- FPR2 p.Ser73Phe Uncertain significance Single submitter
- FPR2 p.Thr196Ile Uncertain significance Single submitter
- FPR2 p.Thr287Ala Uncertain significance Single submitter
- FPR2 p.Thr75Met Uncertain significance Single submitter
- FPR2 p.Trp95Arg Uncertain significance Single submitter
- FPR2 p.Tyr175His Uncertain significance Single submitter
- FPR2 p.Tyr302His Uncertain significance Single submitter
- FPR2 p.Val247Ala Uncertain significance Single submitter
- FPR2 p.Val266Ile Uncertain significance Single submitter
- FPR2 p.Val32Ala Uncertain significance Single submitter
- FPR2 p.Val59Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- FPR2 p.Phe74Leu Benign/Likely benign Multiple submitters
- FPR2 p.Arg57Cys Uncertain significance Single submitter
- FPR2 p.Gly148Arg Uncertain significance Single submitter
- FPR2 p.Gly172Trp Uncertain significance Single submitter
- FPR2 p.Gly34Arg Uncertain significance Single submitter
- FPR2 p.Phe114Leu Uncertain significance Single submitter
- FPR2 p.Phe251Leu Uncertain significance Single submitter
- FPR2 p.Val303Leu Uncertain significance Single submitter
All FPR2 variants
Benign/Likely benign 1
- p.Phe74Leu Multiple submitters ⚠
Likely benign 3
- p.Arg26Gln Single submitter
- p.Glu347= Single submitter
- p.Val15Ala Single submitter
Uncertain significance 42
- c.-15+1402C>T Single submitter lung adenocarcinoma
- p.Ala245Val Single submitter ⚠
- p.Ala248Ser Single submitter ⚠
- p.Arg137Cys Single submitter
- p.Arg57Cys Single submitter ⚠
- p.Arg57His Single submitter ⚠
- p.Cys296Trp Single submitter ⚠
- p.Cys98Arg Single submitter ⚠
- p.Glu311Asp Single submitter ⚠
- p.Gly148Arg Single submitter ⚠
- p.Gly172Trp Single submitter ⚠
- p.Gly34Arg Single submitter ⚠
- p.Gly40Arg Single submitter ⚠
- p.His136Tyr Single submitter ⚠
- p.His315Tyr Single submitter ⚠
- p.Ile116Val Single submitter ⚠
- p.Ile27Leu Single submitter ⚠
- p.Leu128Arg Single submitter ⚠
- p.Leu272Phe Single submitter ⚠
- p.Lys227Asn Single submitter ⚠
- p.Met197Ile Single submitter ⚠
- p.Met197Val Single submitter ⚠
- p.Met85Thr Single submitter ⚠
- p.Phe114Leu Single submitter ⚠
- p.Phe251Leu Single submitter ⚠
- p.Pro213Leu Single submitter ⚠
- p.Pro299Arg Single submitter ⚠
- p.Pro8Thr Single submitter ⚠
- p.Ser112Asn Single submitter ⚠
- p.Ser73Phe Single submitter ⚠
- p.Thr196Ile Single submitter ⚠
- p.Thr287Ala Single submitter ⚠
- p.Thr75Met Single submitter ⚠
- p.Trp95Arg Single submitter ⚠
- p.Tyr175His Single submitter ⚠
- p.Tyr302His Single submitter ⚠
- p.Val246Met Single submitter
- p.Val247Ala Single submitter ⚠
- p.Val266Ile Single submitter ⚠
- p.Val303Leu Single submitter ⚠
- p.Val32Ala Single submitter ⚠
- p.Val59Ile Single submitter ⚠