FPR3 — 38 ClinVar variants
All ClinVar germline FPR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
7 Likely benign · 31 Uncertain significance
Full FPR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FPR3 p.Ala198Gly Uncertain significance Single submitter
- FPR3 p.Ala244Val Uncertain significance Single submitter
- FPR3 p.Ala86Thr Uncertain significance Single submitter
- FPR3 p.Arg123His Uncertain significance Single submitter
- FPR3 p.Arg241Cys Uncertain significance Single submitter
- FPR3 p.Arg57His Uncertain significance Single submitter
- FPR3 p.Asn274Tyr Uncertain significance Single submitter
- FPR3 p.Glu258Lys Uncertain significance Single submitter
- FPR3 p.Glu346Lys Uncertain significance Single submitter
- FPR3 p.Glu347Gln Uncertain significance Single submitter
- FPR3 p.Gly43Asp Uncertain significance Single submitter
- FPR3 p.His129Gln Uncertain significance Single submitter
- FPR3 p.Ile195Thr Uncertain significance Single submitter
- FPR3 p.Ile224Val Uncertain significance Single submitter
- FPR3 p.Ile234Ser Uncertain significance Single submitter
- FPR3 p.Ile27Phe Uncertain significance Single submitter
- FPR3 p.Ile77Val Uncertain significance Single submitter
- FPR3 p.Met305Leu Uncertain significance Single submitter
- FPR3 p.Phe93Ser Uncertain significance Single submitter
- FPR3 p.Thr170Ala Uncertain significance Single submitter
- FPR3 p.Thr170Met Uncertain significance Single submitter
- FPR3 p.Thr340Ala Uncertain significance Single submitter
- FPR3 p.Val24Ile Uncertain significance Single submitter
- FPR3 p.Val303Ile Uncertain significance Single submitter
- FPR3 p.Val328Gly Uncertain significance Single submitter
- FPR3 p.Val35Asp Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All FPR3 variants
Likely benign 7
- p.Arg315His Single submitter
- p.Asp173Asn Single submitter
- p.Ile154Thr Single submitter
- p.Ile167Val Single submitter
- p.Ile300Val Single submitter
- p.Pro19Ser Single submitter
- p.Thr218Ala Single submitter
Uncertain significance 31
- p.Ala198Gly Single submitter ⚠
- p.Ala244Val Single submitter ⚠
- p.Ala86Thr Single submitter ⚠
- p.Arg123His Single submitter ⚠
- p.Arg241Cys Single submitter ⚠
- p.Arg57His Single submitter ⚠
- p.Asn274Tyr Single submitter ⚠
- p.Cys124Ser Single submitter ⚠
- p.Glu258Lys Single submitter ⚠
- p.Glu346Lys Single submitter ⚠
- p.Glu347Gln Single submitter ⚠
- p.Gly306Asp Single submitter ⚠
- p.Gly34Arg Single submitter ⚠
- p.Gly43Asp Single submitter ⚠
- p.His129Gln Single submitter ⚠
- p.Ile195Thr Single submitter ⚠
- p.Ile224Val Single submitter ⚠
- p.Ile234Ser Single submitter ⚠
- p.Ile27Phe Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Met305Leu Single submitter ⚠
- p.Phe80Leu Single submitter ⚠
- p.Phe93Ser Single submitter ⚠
- p.Pro159Thr Single submitter ⚠
- p.Thr170Ala Single submitter ⚠
- p.Thr170Met Single submitter ⚠
- p.Thr340Ala Single submitter ⚠
- p.Val24Ile Single submitter ⚠
- p.Val303Ile Single submitter ⚠
- p.Val328Gly Single submitter ⚠
- p.Val35Asp Single submitter ⚠