Sugi Variant

Sugi Variant/GIT1

GIT1 — 103 ClinVar variants

All ClinVar germline GIT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →

2 Pathogenic · 1 Conflicting · 3 Benign · 19 Likely benign · 78 Uncertain significance

Full GIT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 72

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 64

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 7

The independent predictors disagree with each other — read with care.

All GIT1 variants

Pathogenic 2

Conflicting classifications of pathogenicity 1

Benign 3

Likely benign 19

Uncertain significance 78