GLG1 — 138 ClinVar variants
All ClinVar germline GLG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 124 flagged for review →
2 Benign · 3 Likely benign · 133 Uncertain significance
Full GLG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 124
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GLG1 p.Arg989Gln Uncertain significance Multiple submitters
- GLG1 p.Ala104Ser Uncertain significance Single submitter
- GLG1 p.Ala1080Thr Uncertain significance Single submitter
- GLG1 p.Ala136Gly Uncertain significance Single submitter
- GLG1 p.Ala15Ser Uncertain significance Single submitter
- GLG1 p.Ala2Val Uncertain significance Single submitter
- GLG1 p.Ala329Val Uncertain significance Single submitter
- GLG1 p.Ala3Val Uncertain significance Single submitter
- GLG1 p.Ala634Pro Uncertain significance Single submitter
- GLG1 p.Ala792Val Uncertain significance Single submitter
- GLG1 p.Ala836Ser Uncertain significance Single submitter
- GLG1 p.Arg1115Trp Uncertain significance Single submitter
- GLG1 p.Arg317Gln Uncertain significance Single submitter
- GLG1 p.Arg352Gln Uncertain significance Single submitter
- GLG1 p.Arg445Gly Uncertain significance Single submitter
- GLG1 p.Arg460Gln Uncertain significance Single submitter
- GLG1 p.Arg470Gln Uncertain significance Single submitter
- GLG1 p.Arg545Cys Uncertain significance Single submitter
- GLG1 p.Arg565His Uncertain significance Single submitter
- GLG1 p.Arg573Cys Uncertain significance Single submitter
- GLG1 p.Arg573His Uncertain significance Single submitter
- GLG1 p.Arg806His Uncertain significance Single submitter
- GLG1 p.Arg858Gly Uncertain significance Single submitter
- GLG1 p.Arg8Gly Uncertain significance Single submitter
- GLG1 p.Asn1145Lys Uncertain significance Single submitter
- GLG1 p.Asn45Lys Uncertain significance Single submitter
- GLG1 p.Asn504Ser Uncertain significance Single submitter
- GLG1 p.Asp154Gly Uncertain significance Single submitter
- GLG1 p.Asp729Asn Uncertain significance Single submitter
- GLG1 p.Cys4Gly Uncertain significance Single submitter
- GLG1 p.Gln902Arg Uncertain significance Single submitter
- GLG1 p.Glu1044Ala Uncertain significance Single submitter
- GLG1 p.Glu282Ala Uncertain significance Single submitter
- GLG1 p.Glu585Asp Uncertain significance Single submitter
- GLG1 p.Glu605Asp Uncertain significance Single submitter
- GLG1 p.Glu613Val Uncertain significance Single submitter
- GLG1 p.Gly103Arg Uncertain significance Single submitter
- GLG1 p.Gly26Arg Uncertain significance Single submitter
- GLG1 p.Gly26Glu Uncertain significance Single submitter
- GLG1 p.Gly273Val Uncertain significance Single submitter
- GLG1 p.Gly494Ala Uncertain significance Single submitter
- GLG1 p.Gly56Arg Uncertain significance Single submitter
- GLG1 p.Gly579Val Uncertain significance Single submitter
- GLG1 p.His450Gln Uncertain significance Single submitter
- GLG1 p.His544Tyr Uncertain significance Single submitter
- GLG1 p.His795Leu Uncertain significance Single submitter
- GLG1 p.His795Pro Uncertain significance Single submitter
- GLG1 p.Ile1061Val Uncertain significance Single submitter
- GLG1 p.Ile1157Val Uncertain significance Single submitter
- GLG1 p.Ile184Val Uncertain significance Single submitter
- GLG1 p.Ile736Val Uncertain significance Single submitter
- GLG1 p.Ile830Val Uncertain significance Single submitter
- GLG1 p.Ile921Val Uncertain significance Single submitter
- GLG1 p.Ile968Val Uncertain significance Single submitter
- GLG1 p.Leu1045Phe Uncertain significance Single submitter
- GLG1 p.Leu255Ile Uncertain significance Single submitter
- GLG1 p.Leu963Phe Uncertain significance Single submitter
- GLG1 p.Lys171Arg Uncertain significance Single submitter
- GLG1 p.Lys276Thr Uncertain significance Single submitter
- GLG1 p.Lys292Arg Uncertain significance Single submitter
- GLG1 p.Lys374Ile Uncertain significance Single submitter
- GLG1 p.Met10Ile Uncertain significance Single submitter
- GLG1 p.Met10Leu Uncertain significance Single submitter
- GLG1 p.Met937Ile Uncertain significance Single submitter
- GLG1 p.Pro58Leu Uncertain significance Single submitter
- GLG1 p.Pro67Ser Uncertain significance Single submitter
- GLG1 p.Pro893Leu Uncertain significance Single submitter
- GLG1 p.Pro98Leu Uncertain significance Single submitter
- GLG1 p.Ser1015Gly Uncertain significance Single submitter
- GLG1 p.Ser117Phe Uncertain significance Single submitter
- GLG1 p.Ser14Leu Uncertain significance Single submitter
- GLG1 p.Ser435Ala Uncertain significance Single submitter
- GLG1 p.Ser435Pro Uncertain significance Single submitter
- GLG1 p.Ser443Asn Uncertain significance Single submitter
- GLG1 p.Ser70Leu Uncertain significance Single submitter
- GLG1 p.Thr1069Ala Uncertain significance Single submitter
- GLG1 p.Thr168Ile Uncertain significance Single submitter
- GLG1 p.Thr185Arg Uncertain significance Single submitter
- GLG1 p.Thr224Met Uncertain significance Single submitter
- GLG1 p.Thr327Ile Uncertain significance Single submitter
- GLG1 p.Thr577Asn Uncertain significance Single submitter
- GLG1 p.Thr739Ser Uncertain significance Single submitter
- GLG1 p.Thr782Met Uncertain significance Single submitter
- GLG1 p.Val668Leu Uncertain significance Single submitter
- GLG1 p.Val668Met Uncertain significance Single submitter
- GLG1 p.Val707Met Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- GLG1 p.Ala408Val Uncertain significance Single submitter
- GLG1 p.Arg1111Cys Uncertain significance Single submitter
- GLG1 p.Arg498His Uncertain significance Single submitter
- GLG1 p.Arg555Gln Uncertain significance Single submitter
- GLG1 p.Arg602Cys Uncertain significance Single submitter
- GLG1 p.Arg6Cys Uncertain significance Single submitter
- GLG1 p.Arg858Cys Uncertain significance Single submitter
- GLG1 p.Arg8Trp Uncertain significance Single submitter
- GLG1 p.Asn786Ser Uncertain significance Single submitter
- GLG1 p.Asp121Val Uncertain significance Single submitter
- GLG1 p.Asp169Asn Uncertain significance Single submitter
- GLG1 p.Asp304His Uncertain significance Single submitter
- GLG1 p.Asp522Glu Uncertain significance Single submitter
- GLG1 p.Gln75Arg Uncertain significance Single submitter
- GLG1 p.Gln76Lys Uncertain significance Single submitter
- GLG1 p.Gln925His Uncertain significance Single submitter
- GLG1 p.Gln925Leu Uncertain significance Single submitter
- GLG1 p.Glu139Val Uncertain significance Single submitter
- GLG1 p.Glu178Gly Uncertain significance Single submitter
- GLG1 p.Glu321Asp Uncertain significance Single submitter
- GLG1 p.Glu719Gly Uncertain significance Single submitter
- GLG1 p.Gly421Arg Uncertain significance Single submitter
- GLG1 p.Gly676Val Uncertain significance Single submitter
- GLG1 p.His456Arg Uncertain significance Single submitter
- GLG1 p.His599Tyr Uncertain significance Single submitter
- GLG1 p.Leu112Val Uncertain significance Single submitter
- GLG1 p.Leu954Arg Uncertain significance Single submitter
- GLG1 p.Lys1100Asn Uncertain significance Single submitter
- GLG1 p.Lys128Thr Uncertain significance Single submitter
- GLG1 p.Lys566Thr Uncertain significance Single submitter
- GLG1 p.Lys728Asn Uncertain significance Single submitter
- GLG1 p.Met223Leu Uncertain significance Single submitter
- GLG1 p.Met403Thr Uncertain significance Single submitter
- GLG1 p.Phe593Leu Uncertain significance Single submitter
- GLG1 p.Phe755Leu Uncertain significance Single submitter
- GLG1 p.Ser443Arg Uncertain significance Single submitter
- GLG1 p.Thr356Ile Uncertain significance Single submitter
- GLG1 p.Val776Met Uncertain significance Single submitter
All GLG1 variants
Benign 2
- p.Leu204= Multiple submitters
- c.439-7C>T Single submitter
Likely benign 3
- c.774+5C>G Single submitter
- c.*1040C>T Single submitter
- p.Thr1169= Single submitter
Uncertain significance 133
- p.Arg989Gln Multiple submitters ⚠
- c.1224_1234+5del Single submitter
- c.*1041A>C Single submitter
- c.*1056C>A Single submitter
- c.*1100A>G Single submitter
- p.Ala104Ser Single submitter ⚠
- p.Ala1080Thr Single submitter ⚠
- p.Ala136Gly Single submitter ⚠
- p.Ala15Ser Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala329Val Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala408Val Single submitter ⚠
- p.Ala634Pro Single submitter ⚠
- p.Ala792Val Single submitter ⚠
- p.Ala836Ser Single submitter ⚠
- p.Arg1088His Single submitter
- p.Arg1111Cys Single submitter ⚠
- p.Arg1115Trp Single submitter ⚠
- p.Arg232His Single submitter
- p.Arg317Gln Single submitter ⚠
- p.Arg352Gln Single submitter ⚠
- p.Arg445Gly Single submitter ⚠
- p.Arg460Gln Single submitter ⚠
- p.Arg470Gln Single submitter ⚠
- p.Arg498His Single submitter ⚠
- p.Arg545Cys Single submitter ⚠
- p.Arg555Gln Single submitter ⚠
- p.Arg565Cys Single submitter
- p.Arg565His Single submitter ⚠
- p.Arg573Cys Single submitter ⚠
- p.Arg573His Single submitter ⚠
- p.Arg602Cys Single submitter ⚠
- p.Arg6Cys Single submitter ⚠
- p.Arg750Gln Single submitter
- p.Arg806His Single submitter ⚠
- p.Arg858Cys Single submitter ⚠
- p.Arg858Gly Single submitter ⚠
- p.Arg8Gly Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Asn1145Lys Single submitter ⚠
- p.Asn45Lys Single submitter ⚠
- p.Asn504Ser Single submitter ⚠
- p.Asn786Ser Single submitter ⚠
- p.Asp121Val Single submitter ⚠
- p.Asp154Gly Single submitter ⚠
- p.Asp169Asn Single submitter ⚠
- p.Asp304His Single submitter ⚠
- p.Asp522Glu Single submitter ⚠
- p.Asp729Asn Single submitter ⚠
- p.Cys4Gly Single submitter ⚠
- p.Gln75Arg Single submitter ⚠
- p.Gln76Lys Single submitter ⚠
- p.Gln902Arg Single submitter ⚠
- p.Gln925His Single submitter ⚠
- p.Gln925Leu Single submitter ⚠
- p.Glu1044Ala Single submitter ⚠
- p.Glu139Val Single submitter ⚠
- p.Glu178Gly Single submitter ⚠
- p.Glu282Ala Single submitter ⚠
- p.Glu321Asp Single submitter ⚠
- p.Glu585Asp Single submitter ⚠
- p.Glu605Asp Single submitter ⚠
- p.Glu613Val Single submitter ⚠
- p.Glu719Gly Single submitter ⚠
- p.Gly103Arg Single submitter ⚠
- p.Gly26Arg Single submitter ⚠
- p.Gly26Glu Single submitter ⚠
- p.Gly273Val Single submitter ⚠
- p.Gly421Arg Single submitter ⚠
- p.Gly494Ala Single submitter ⚠
- p.Gly56Arg Single submitter ⚠
- p.Gly579Val Single submitter ⚠
- p.Gly676Val Single submitter ⚠
- p.His450Gln Single submitter ⚠
- p.His456Arg Single submitter ⚠
- p.His544Tyr Single submitter ⚠
- p.His599Tyr Single submitter ⚠
- p.His795Leu Single submitter ⚠
- p.His795Pro Single submitter ⚠
- p.Ile1061Val Single submitter ⚠
- p.Ile1157Val Single submitter ⚠
- p.Ile184Val Single submitter ⚠
- p.Ile736Val Single submitter ⚠
- p.Ile830Val Single submitter ⚠
- p.Ile921Val Single submitter ⚠
- p.Ile968Val Single submitter ⚠
- p.Leu1045Phe Single submitter ⚠
- p.Leu112Val Single submitter ⚠
- p.Leu255Ile Single submitter ⚠
- p.Leu954Arg Single submitter ⚠
- p.Leu963Phe Single submitter ⚠
- p.Lys1100Asn Single submitter ⚠
- p.Lys128Thr Single submitter ⚠
- p.Lys171Arg Single submitter ⚠
- p.Lys276Thr Single submitter ⚠
- p.Lys292Arg Single submitter ⚠
- p.Lys374Ile Single submitter ⚠
- p.Lys566Thr Single submitter ⚠
- p.Lys728Asn Single submitter ⚠
- p.Met10Ile Single submitter ⚠
- p.Met10Leu Single submitter ⚠
- p.Met223Leu Single submitter ⚠
- p.Met403Thr Single submitter ⚠
- p.Met937Ile Single submitter ⚠
- p.Phe593Leu Single submitter ⚠
- p.Phe755Leu Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Pro67Ser Single submitter ⚠
- p.Pro893Leu Single submitter ⚠
- p.Pro947Leu Single submitter
- p.Pro98Leu Single submitter ⚠
- p.Ser1015Gly Single submitter ⚠
- p.Ser117Phe Single submitter ⚠
- p.Ser14Leu Single submitter ⚠
- p.Ser435Ala Single submitter ⚠
- p.Ser435Pro Single submitter ⚠
- p.Ser443Arg Single submitter ⚠
- p.Ser443Asn Single submitter ⚠
- p.Ser70Leu Single submitter ⚠
- p.Thr1069Ala Single submitter ⚠
- p.Thr168Ile Single submitter ⚠
- p.Thr185Arg Single submitter ⚠
- p.Thr224Met Single submitter ⚠
- p.Thr327Ile Single submitter ⚠
- p.Thr356Ile Single submitter ⚠
- p.Thr577Asn Single submitter ⚠
- p.Thr739Ser Single submitter ⚠
- p.Thr782Met Single submitter ⚠
- p.Val668Leu Single submitter ⚠
- p.Val668Met Single submitter ⚠
- p.Val707Met Single submitter ⚠
- p.Val776Met Single submitter ⚠