GNA15 — 62 ClinVar variants
All ClinVar germline GNA15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
3 Benign · 1 Likely benign · 58 Uncertain significance
Full GNA15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GNA15 p.Ala132Ser Uncertain significance Single submitter
- GNA15 p.Ala179Gly Uncertain significance Single submitter
- GNA15 p.Ala22Ser Uncertain significance Single submitter
- GNA15 p.Ala233Val Uncertain significance Single submitter
- GNA15 p.Ala68Thr Uncertain significance Single submitter
- GNA15 p.Arg169Cys Uncertain significance Single submitter
- GNA15 p.Arg184Cys Uncertain significance Single submitter
- GNA15 p.Arg186His Uncertain significance Single submitter
- GNA15 p.Arg205Trp Uncertain significance Single submitter
- GNA15 p.Arg23Gln Uncertain significance Single submitter
- GNA15 p.Arg250His Uncertain significance Single submitter
- GNA15 p.Arg310Lys Uncertain significance Single submitter
- GNA15 p.Arg338Cys Uncertain significance Single submitter
- GNA15 p.Arg40His Uncertain significance Single submitter
- GNA15 p.Arg75Cys Uncertain significance Single submitter
- GNA15 p.Arg8His Uncertain significance Single submitter
- GNA15 p.Arg99Gln Uncertain significance Single submitter
- GNA15 p.Asn193Ser Uncertain significance Single submitter
- GNA15 p.Asp369Glu Uncertain significance Single submitter
- GNA15 p.Gln247Arg Uncertain significance Single submitter
- GNA15 p.Gln350His Uncertain significance Single submitter
- GNA15 p.Glu168Asp Uncertain significance Single submitter
- GNA15 p.Glu16Asp Uncertain significance Single submitter
- GNA15 p.Glu224Lys Uncertain significance Single submitter
- GNA15 p.Gly326Cys Uncertain significance Single submitter
- GNA15 p.His155Asn Uncertain significance Single submitter
- GNA15 p.His166Tyr Uncertain significance Single submitter
- GNA15 p.Ile227Asn Uncertain significance Single submitter
- GNA15 p.Ile31Phe Uncertain significance Single submitter
- GNA15 p.Leu156Gln Uncertain significance Single submitter
- GNA15 p.Leu33Val Uncertain significance Single submitter
- GNA15 p.Lys302Glu Uncertain significance Single submitter
- GNA15 p.Met117Ile Uncertain significance Single submitter
- GNA15 p.Met251Arg Uncertain significance Single submitter
- GNA15 p.Met62Arg Uncertain significance Single submitter
- GNA15 p.Pro103Ala Uncertain significance Single submitter
- GNA15 p.Ser105Asn Uncertain significance Single submitter
- GNA15 p.Ser4Leu Uncertain significance Single submitter
- GNA15 p.Ser53Arg Uncertain significance Single submitter
- GNA15 p.Thr202Ala Uncertain significance Single submitter
- GNA15 p.Thr279Ser Uncertain significance Single submitter
- GNA15 p.Thr317Ser Uncertain significance Single submitter
- GNA15 p.Val199Met Uncertain significance Single submitter
- GNA15 p.Val324Gly Uncertain significance Single submitter
- GNA15 p.Val88Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- GNA15 p.Arg150His Uncertain significance Single submitter
- GNA15 p.Arg169His Uncertain significance Single submitter
- GNA15 p.Arg353Cys Uncertain significance Single submitter
- GNA15 p.Glu283Gly Uncertain significance Single submitter
- GNA15 p.Glu72Val Uncertain significance Single submitter
- GNA15 p.Gly69Ser Uncertain significance Single submitter
- GNA15 p.Met251Leu Uncertain significance Single submitter
- GNA15 p.Met97Val Uncertain significance Single submitter
- GNA15 p.Pro188Leu Uncertain significance Single submitter
- GNA15 p.Ser71Leu Uncertain significance Single submitter
- GNA15 p.Thr321Pro Uncertain significance Single submitter
- GNA15 p.Val182Met Uncertain significance Single submitter
All GNA15 variants
Benign 3
- p.Met187Ile Multiple submitters
- p.Ser114Asn Multiple submitters
- p.Ser271= Multiple submitters
Likely benign 1
- p.Gln38Arg Single submitter
Uncertain significance 58
- p.Ala132Ser Single submitter ⚠
- p.Ala179Gly Single submitter ⚠
- p.Ala22Ser Single submitter ⚠
- p.Ala233Val Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Arg150His Single submitter ⚠
- p.Arg169Cys Single submitter ⚠
- p.Arg169His Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg186His Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg250His Single submitter ⚠
- p.Arg310Lys Single submitter ⚠
- p.Arg338Cys Single submitter ⚠
- p.Arg353Cys Single submitter ⚠
- p.Arg40His Single submitter ⚠
- p.Arg75Cys Single submitter ⚠
- p.Arg8His Single submitter ⚠
- p.Arg99Gln Single submitter ⚠
- p.Asn193Ser Single submitter ⚠
- p.Asp369Glu Single submitter ⚠
- p.Gln247Arg Single submitter ⚠
- p.Gln350His Single submitter ⚠
- p.Glu168Asp Single submitter ⚠
- p.Glu16Asp Single submitter ⚠
- p.Glu224Lys Single submitter ⚠
- p.Glu283Gly Single submitter ⚠
- p.Glu72Val Single submitter ⚠
- p.Gly326Cys Single submitter ⚠
- p.Gly69Ser Single submitter ⚠
- p.His155Asn Single submitter ⚠
- p.His166Tyr Single submitter ⚠
- p.Ile227Asn Single submitter ⚠
- p.Ile31Phe Single submitter ⚠
- p.Leu156Gln Single submitter ⚠
- p.Leu33Val Single submitter ⚠
- p.Lys302Glu Single submitter ⚠
- p.Met117Ile Single submitter ⚠
- p.Met251Arg Single submitter ⚠
- p.Met251Leu Single submitter ⚠
- p.Met62Arg Single submitter ⚠
- p.Met93Thr Single submitter
- p.Met97Val Single submitter ⚠
- p.Pro103Ala Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Ser105Asn Single submitter ⚠
- p.Ser4Leu Single submitter ⚠
- p.Ser53Arg Single submitter ⚠
- p.Ser71Leu Single submitter ⚠
- p.Thr202Ala Single submitter ⚠
- p.Thr279Ser Single submitter ⚠
- p.Thr317Ser Single submitter ⚠
- p.Thr321Pro Single submitter ⚠
- p.Val182Met Single submitter ⚠
- p.Val199Met Single submitter ⚠
- p.Val324Gly Single submitter ⚠
- p.Val88Leu Single submitter ⚠