GOLIM4 — 106 ClinVar variants
All ClinVar germline GOLIM4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
6 Benign · 6 Likely benign · 94 Uncertain significance
Full GOLIM4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GOLIM4 p.Arg669Gln Uncertain significance Multiple submitters
- GOLIM4 p.Ala342Ser Uncertain significance Single submitter
- GOLIM4 p.Ala354Thr Uncertain significance Single submitter
- GOLIM4 p.Ala354Val Uncertain significance Single submitter
- GOLIM4 p.Ala389Pro Uncertain significance Single submitter
- GOLIM4 p.Ala389Thr Uncertain significance Single submitter
- GOLIM4 p.Ala389Val Uncertain significance Single submitter
- GOLIM4 p.Ala391Asp Uncertain significance Single submitter
- GOLIM4 p.Ala45Ser Uncertain significance Single submitter
- GOLIM4 p.Ala544Pro Uncertain significance Single submitter
- GOLIM4 p.Ala687Val Uncertain significance Single submitter
- GOLIM4 p.Ala96Thr Uncertain significance Single submitter
- GOLIM4 p.Arg140His Uncertain significance Single submitter
- GOLIM4 p.Arg284Gln Uncertain significance Single submitter
- GOLIM4 p.Arg327His Uncertain significance Single submitter
- GOLIM4 p.Arg370Gln Uncertain significance Single submitter
- GOLIM4 p.Arg379Gln Uncertain significance Single submitter
- GOLIM4 p.Arg428Gln Uncertain significance Single submitter
- GOLIM4 p.Arg428Trp Uncertain significance Single submitter
- GOLIM4 p.Arg445Trp Uncertain significance Single submitter
- GOLIM4 p.Arg470Trp Uncertain significance Single submitter
- GOLIM4 p.Arg478Trp Uncertain significance Single submitter
- GOLIM4 p.Arg665Leu Uncertain significance Single submitter
- GOLIM4 p.Arg669Gly Uncertain significance Single submitter
- GOLIM4 p.Arg692Gly Uncertain significance Single submitter
- GOLIM4 p.Asn151Asp Uncertain significance Single submitter
- GOLIM4 p.Asn549His Uncertain significance Single submitter
- GOLIM4 p.Asn584His Uncertain significance Single submitter
- GOLIM4 p.Asn584Ser Uncertain significance Single submitter
- GOLIM4 p.Asn589Lys Uncertain significance Single submitter
- GOLIM4 p.Asn664Ser Uncertain significance Single submitter
- GOLIM4 p.Asp106Asn Uncertain significance Single submitter
- GOLIM4 p.Asp514Gly Uncertain significance Single submitter
- GOLIM4 p.Asp624Gly Uncertain significance Single submitter
- GOLIM4 p.Asp662Glu Uncertain significance Single submitter
- GOLIM4 p.Gln290Arg Uncertain significance Single submitter
- GOLIM4 p.Gln437Glu Uncertain significance Single submitter
- GOLIM4 p.Gln480Glu Uncertain significance Single submitter
- GOLIM4 p.Gln492Arg Uncertain significance Single submitter
- GOLIM4 p.Gln513Glu Uncertain significance Single submitter
- GOLIM4 p.Gln587Arg Uncertain significance Single submitter
- GOLIM4 p.Glu209Val Uncertain significance Single submitter
- GOLIM4 p.Glu331Ala Uncertain significance Single submitter
- GOLIM4 p.Glu371Gln Uncertain significance Single submitter
- GOLIM4 p.Glu380Lys Uncertain significance Single submitter
- GOLIM4 p.Glu495Val Uncertain significance Single submitter
- GOLIM4 p.Glu546Val Uncertain significance Single submitter
- GOLIM4 p.Glu566Lys Uncertain significance Single submitter
- GOLIM4 p.Glu639Asp Uncertain significance Single submitter
- GOLIM4 p.Glu87Gln Uncertain significance Single submitter
- GOLIM4 p.Gly297Arg Uncertain significance Single submitter
- GOLIM4 p.Gly441Val Uncertain significance Single submitter
- GOLIM4 p.Gly521Asp Uncertain significance Single submitter
- GOLIM4 p.His524Asn Uncertain significance Single submitter
- GOLIM4 p.His524Leu Uncertain significance Single submitter
- GOLIM4 p.His672Tyr Uncertain significance Single submitter
- GOLIM4 p.Ile244Met Uncertain significance Single submitter
- GOLIM4 p.Leu573Phe Uncertain significance Single submitter
- GOLIM4 p.Lys42Arg Uncertain significance Single submitter
- GOLIM4 p.Lys667Arg Uncertain significance Single submitter
- GOLIM4 p.Lys93Gln Uncertain significance Single submitter
- GOLIM4 p.Met120Val Uncertain significance Single submitter
- GOLIM4 p.Met486Thr Uncertain significance Single submitter
- GOLIM4 p.Pro252Ser Uncertain significance Single submitter
- GOLIM4 p.Pro317Ser Uncertain significance Single submitter
- GOLIM4 p.Pro320Ser Uncertain significance Single submitter
- GOLIM4 p.Pro471Leu Uncertain significance Single submitter
- GOLIM4 p.Pro526Ala Uncertain significance Single submitter
- GOLIM4 p.Pro531Ser Uncertain significance Single submitter
- GOLIM4 p.Ser56Tyr Uncertain significance Single submitter
- GOLIM4 p.Ser583Asn Uncertain significance Single submitter
- GOLIM4 p.Thr149Ile Uncertain significance Single submitter
- GOLIM4 p.Thr259Ile Uncertain significance Single submitter
- GOLIM4 p.Tyr33His Uncertain significance Single submitter
- GOLIM4 p.Tyr92Cys Uncertain significance Single submitter
- GOLIM4 p.Val22Leu Uncertain significance Single submitter
- GOLIM4 p.Val335Met Uncertain significance Single submitter
- GOLIM4 p.Val454Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- GOLIM4 p.Ala227Thr Uncertain significance Single submitter
- GOLIM4 p.Arg665Cys Uncertain significance Single submitter
- GOLIM4 p.Asp603Glu Uncertain significance Single submitter
- GOLIM4 p.Gln60Glu Uncertain significance Single submitter
- GOLIM4 p.Glu180Lys Uncertain significance Single submitter
- GOLIM4 p.Gly103Glu Uncertain significance Single submitter
- GOLIM4 p.His203Arg Uncertain significance Single submitter
- GOLIM4 p.His220Tyr Uncertain significance Single submitter
- GOLIM4 p.Lys77Asn Uncertain significance Single submitter
- GOLIM4 p.Met120Ile Uncertain significance Single submitter
- GOLIM4 p.Phe14Leu Uncertain significance Single submitter
- GOLIM4 p.Ser222Arg Uncertain significance Single submitter
- GOLIM4 p.Tyr506Cys Uncertain significance Single submitter
- GOLIM4 p.Val199Leu Uncertain significance Single submitter
- GOLIM4 p.Val231Ala Uncertain significance Single submitter
All GOLIM4 variants
Benign 6
- c.1177-5C>T Multiple submitters
- c.1514-5G>T Multiple submitters
- p.Gln453Arg Multiple submitters
- c.313-10del Single submitter
- c.313-10dup Single submitter
- p.Gly441= Single submitter
Likely benign 6
- p.Ala389= Single submitter
- p.Arg390His Single submitter
- p.Asn269Ser Single submitter
- p.Asp535Asn Single submitter
- p.Glu537= Single submitter
- p.Val418Ala Single submitter
Uncertain significance 94
- p.Arg669Gln Multiple submitters ⚠
- p.Ala227Thr Single submitter ⚠
- p.Ala342Ser Single submitter ⚠
- p.Ala354Thr Single submitter ⚠
- p.Ala354Val Single submitter ⚠
- p.Ala389Pro Single submitter ⚠
- p.Ala389Thr Single submitter ⚠
- p.Ala389Val Single submitter ⚠
- p.Ala391Asp Single submitter ⚠
- p.Ala45Ser Single submitter ⚠
- p.Ala544Pro Single submitter ⚠
- p.Ala687Val Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Arg140His Single submitter ⚠
- p.Arg284Gln Single submitter ⚠
- p.Arg327His Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg379Gln Single submitter ⚠
- p.Arg428Gln Single submitter ⚠
- p.Arg428Trp Single submitter ⚠
- p.Arg445Trp Single submitter ⚠
- p.Arg470Trp Single submitter ⚠
- p.Arg478Trp Single submitter ⚠
- p.Arg665Cys Single submitter ⚠
- p.Arg665Leu Single submitter ⚠
- p.Arg669Gly Single submitter ⚠
- p.Arg692Gly Single submitter ⚠
- p.Asn151Asp Single submitter ⚠
- p.Asn549His Single submitter ⚠
- p.Asn584His Single submitter ⚠
- p.Asn584Ser Single submitter ⚠
- p.Asn589Lys Single submitter ⚠
- p.Asn664Ser Single submitter ⚠
- p.Asp106Asn Single submitter ⚠
- p.Asp514Gly Single submitter ⚠
- p.Asp603Glu Single submitter ⚠
- p.Asp624Gly Single submitter ⚠
- p.Asp662Glu Single submitter ⚠
- p.Gln290Arg Single submitter ⚠
- p.Gln437Glu Single submitter ⚠
- p.Gln480Glu Single submitter ⚠
- p.Gln492Arg Single submitter ⚠
- p.Gln513Glu Single submitter ⚠
- p.Gln587Arg Single submitter ⚠
- p.Gln60Glu Single submitter ⚠
- p.Glu180Lys Single submitter ⚠
- p.Glu209Val Single submitter ⚠
- p.Glu331Ala Single submitter ⚠
- p.Glu371Gln Single submitter ⚠
- p.Glu380Lys Single submitter ⚠
- p.Glu44Lys Single submitter
- p.Glu495Val Single submitter ⚠
- p.Glu546Val Single submitter ⚠
- p.Glu566Lys Single submitter ⚠
- p.Glu639Asp Single submitter ⚠
- p.Glu87Gln Single submitter ⚠
- p.Gly103Glu Single submitter ⚠
- p.Gly297Arg Single submitter ⚠
- p.Gly441Val Single submitter ⚠
- p.Gly521Asp Single submitter ⚠
- p.His203Arg Single submitter ⚠
- p.His220Tyr Single submitter ⚠
- p.His524Asn Single submitter ⚠
- p.His524Leu Single submitter ⚠
- p.His672Tyr Single submitter ⚠
- p.Ile244Met Single submitter ⚠
- p.Leu573Phe Single submitter ⚠
- p.Lys42Arg Single submitter ⚠
- p.Lys667Arg Single submitter ⚠
- p.Lys77Asn Single submitter ⚠
- p.Lys93Gln Single submitter ⚠
- p.Met120Ile Single submitter ⚠
- p.Met120Val Single submitter ⚠
- p.Met486Thr Single submitter ⚠
- p.Phe14Leu Single submitter ⚠
- p.Pro252Ser Single submitter ⚠
- p.Pro317Ser Single submitter ⚠
- p.Pro320Ser Single submitter ⚠
- p.Pro471Leu Single submitter ⚠
- p.Pro526Ala Single submitter ⚠
- p.Pro531Ser Single submitter ⚠
- p.Ser222Arg Single submitter ⚠
- p.Ser56Tyr Single submitter ⚠
- p.Ser583Asn Single submitter ⚠
- p.Thr149Ile Single submitter ⚠
- p.Thr259Ile Single submitter ⚠
- p.Tyr33His Single submitter ⚠
- p.Tyr506Cys Single submitter ⚠
- p.Tyr92Cys Single submitter ⚠
- p.Val199Leu Single submitter ⚠
- p.Val22Leu Single submitter ⚠
- p.Val231Ala Single submitter ⚠
- p.Val335Met Single submitter ⚠
- p.Val454Ala Single submitter ⚠