GPATCH2 — 65 ClinVar variants
All ClinVar germline GPATCH2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
5 Likely benign · 60 Uncertain significance
Full GPATCH2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPATCH2 p.Ala396Val Uncertain significance Single submitter
- GPATCH2 p.Arg126His Uncertain significance Single submitter
- GPATCH2 p.Arg137Gln Uncertain significance Single submitter
- GPATCH2 p.Arg218Lys Uncertain significance Single submitter
- GPATCH2 p.Arg347Cys Uncertain significance Single submitter
- GPATCH2 p.Arg410Gln Uncertain significance Single submitter
- GPATCH2 p.Arg74Lys Uncertain significance Single submitter
- GPATCH2 p.Arg7Pro Uncertain significance Single submitter
- GPATCH2 p.Asn131Lys Uncertain significance Single submitter
- GPATCH2 p.Asn135Ser Uncertain significance Single submitter
- GPATCH2 p.Asn155Thr Uncertain significance Single submitter
- GPATCH2 p.Asn239Lys Uncertain significance Single submitter
- GPATCH2 p.Asn409Thr Uncertain significance Single submitter
- GPATCH2 p.Asn468Ser Uncertain significance Single submitter
- GPATCH2 p.Asn523Ser Uncertain significance Single submitter
- GPATCH2 p.Asp196Glu Uncertain significance Single submitter
- GPATCH2 p.Asp241Gly Uncertain significance Single submitter
- GPATCH2 p.Asp389Asn Uncertain significance Single submitter
- GPATCH2 p.Asp93Asn Uncertain significance Single submitter
- GPATCH2 p.Gln200Arg Uncertain significance Single submitter
- GPATCH2 p.Gln202His Uncertain significance Single submitter
- GPATCH2 p.Gln64His Uncertain significance Single submitter
- GPATCH2 p.Glu203Lys Uncertain significance Single submitter
- GPATCH2 p.Glu253Gly Uncertain significance Single submitter
- GPATCH2 p.Glu460Lys Uncertain significance Single submitter
- GPATCH2 p.Glu83Gln Uncertain significance Single submitter
- GPATCH2 p.Gly220Ala Uncertain significance Single submitter
- GPATCH2 p.Gly361Arg Uncertain significance Single submitter
- GPATCH2 p.Gly414Arg Uncertain significance Single submitter
- GPATCH2 p.Gly6Arg Uncertain significance Single submitter
- GPATCH2 p.His144Pro Uncertain significance Single submitter
- GPATCH2 p.His335Gln Uncertain significance Single submitter
- GPATCH2 p.Ile175Phe Uncertain significance Single submitter
- GPATCH2 p.Ile298Val Uncertain significance Single submitter
- GPATCH2 p.Ile356Val Uncertain significance Single submitter
- GPATCH2 p.Leu96Ser Uncertain significance Single submitter
- GPATCH2 p.Lys240Thr Uncertain significance Single submitter
- GPATCH2 p.Lys491Arg Uncertain significance Single submitter
- GPATCH2 p.Pro128Leu Uncertain significance Single submitter
- GPATCH2 p.Pro320Ser Uncertain significance Single submitter
- GPATCH2 p.Pro363Thr Uncertain significance Single submitter
- GPATCH2 p.Pro522Ala Uncertain significance Single submitter
- GPATCH2 p.Pro522Arg Uncertain significance Single submitter
- GPATCH2 p.Pro81Ser Uncertain significance Single submitter
- GPATCH2 p.Ser382Pro Uncertain significance Single submitter
- GPATCH2 p.Ser515Asn Uncertain significance Single submitter
- GPATCH2 p.Thr311Ala Uncertain significance Single submitter
- GPATCH2 p.Thr437Met Uncertain significance Single submitter
- GPATCH2 p.Trp305Arg Uncertain significance Single submitter
- GPATCH2 p.Tyr199His Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- GPATCH2 p.Arg159Cys Uncertain significance Single submitter
- GPATCH2 p.Arg212Ile Uncertain significance Single submitter
- GPATCH2 p.Arg442Gln Uncertain significance Single submitter
- GPATCH2 p.Arg444Lys Uncertain significance Single submitter
- GPATCH2 p.Arg63Leu Uncertain significance Single submitter
- GPATCH2 p.Gly269Ala Uncertain significance Single submitter
- GPATCH2 p.Ile470Thr Uncertain significance Single submitter
- GPATCH2 p.Ser256Asn Uncertain significance Single submitter
- GPATCH2 p.Trp304Leu Uncertain significance Single submitter
All GPATCH2 variants
Likely benign 5
- p.Asn477Ser Single submitter
- p.Gly138= Single submitter
- p.Ser527Pro Single submitter
- p.Val153Leu Single submitter
- p.Gly509fs No assertion criteria long QT syndrome
Uncertain significance 60
- p.Ala396Val Single submitter ⚠
- p.Arg126His Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg159Cys Single submitter ⚠
- p.Arg212Ile Single submitter ⚠
- p.Arg218Lys Single submitter ⚠
- p.Arg347Cys Single submitter ⚠
- p.Arg410Gln Single submitter ⚠
- p.Arg442Gln Single submitter ⚠
- p.Arg444Lys Single submitter ⚠
- p.Arg63Leu Single submitter ⚠
- p.Arg74Lys Single submitter ⚠
- p.Arg7Pro Single submitter ⚠
- p.Asn131Lys Single submitter ⚠
- p.Asn135Ser Single submitter ⚠
- p.Asn155Thr Single submitter ⚠
- p.Asn239Lys Single submitter ⚠
- p.Asn409Thr Single submitter ⚠
- p.Asn468Ser Single submitter ⚠
- p.Asn523Ser Single submitter ⚠
- p.Asp196Glu Single submitter ⚠
- p.Asp241Gly Single submitter ⚠
- p.Asp389Asn Single submitter ⚠
- p.Asp93Asn Single submitter ⚠
- p.Gln200Arg Single submitter ⚠
- p.Gln202His Single submitter ⚠
- p.Gln64His Single submitter ⚠
- p.Glu203Lys Single submitter ⚠
- p.Glu253Gly Single submitter ⚠
- p.Glu460Lys Single submitter ⚠
- p.Glu83Gln Single submitter ⚠
- p.Gly220Ala Single submitter ⚠
- p.Gly269Ala Single submitter ⚠
- p.Gly361Arg Single submitter ⚠
- p.Gly414Arg Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.His144Pro Single submitter ⚠
- p.His335Gln Single submitter ⚠
- p.Ile175Phe Single submitter ⚠
- p.Ile298Val Single submitter ⚠
- p.Ile356Val Single submitter ⚠
- p.Ile470Thr Single submitter ⚠
- p.Leu96Ser Single submitter ⚠
- p.Lys240Thr Single submitter ⚠
- p.Lys491Arg Single submitter ⚠
- p.Met243Thr Single submitter
- p.Pro128Leu Single submitter ⚠
- p.Pro320Ser Single submitter ⚠
- p.Pro363Thr Single submitter ⚠
- p.Pro522Ala Single submitter ⚠
- p.Pro522Arg Single submitter ⚠
- p.Pro81Ser Single submitter ⚠
- p.Ser256Asn Single submitter ⚠
- p.Ser382Pro Single submitter ⚠
- p.Ser515Asn Single submitter ⚠
- p.Thr311Ala Single submitter ⚠
- p.Thr437Met Single submitter ⚠
- p.Trp304Leu Single submitter ⚠
- p.Trp305Arg Single submitter ⚠
- p.Tyr199His Single submitter ⚠