GPR152 — 75 ClinVar variants
All ClinVar germline GPR152 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
13 Likely benign · 62 Uncertain significance
Full GPR152 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR152 p.Ala124Thr Uncertain significance Single submitter
- GPR152 p.Ala133Val Uncertain significance Single submitter
- GPR152 p.Ala153Thr Uncertain significance Single submitter
- GPR152 p.Ala217Thr Uncertain significance Single submitter
- GPR152 p.Ala230Glu Uncertain significance Single submitter
- GPR152 p.Ala231Pro Uncertain significance Single submitter
- GPR152 p.Ala236Asp Uncertain significance Single submitter
- GPR152 p.Ala314Thr Uncertain significance Single submitter
- GPR152 p.Ala346Glu Uncertain significance Single submitter
- GPR152 p.Ala441Thr Uncertain significance Single submitter
- GPR152 p.Ala450Thr Uncertain significance Single submitter
- GPR152 p.Ala467Glu Uncertain significance Single submitter
- GPR152 p.Ala54Val Uncertain significance Single submitter
- GPR152 p.Arg17Cys Uncertain significance Single submitter
- GPR152 p.Arg17His Uncertain significance Single submitter
- GPR152 p.Arg237Cys Uncertain significance Single submitter
- GPR152 p.Arg237His Uncertain significance Single submitter
- GPR152 p.Arg321Trp Uncertain significance Single submitter
- GPR152 p.Arg65Cys Uncertain significance Single submitter
- GPR152 p.Arg92Trp Uncertain significance Single submitter
- GPR152 p.Asp178Asn Uncertain significance Single submitter
- GPR152 p.Asp178Gly Uncertain significance Single submitter
- GPR152 p.Asp301Asn Uncertain significance Single submitter
- GPR152 p.Asp301His Uncertain significance Single submitter
- GPR152 p.Asp401Ala Uncertain significance Single submitter
- GPR152 p.Glu19Asp Uncertain significance Single submitter
- GPR152 p.Gly112Ser Uncertain significance Single submitter
- GPR152 p.Gly118Ser Uncertain significance Single submitter
- GPR152 p.Gly154Ser Uncertain significance Single submitter
- GPR152 p.His224Leu Uncertain significance Single submitter
- GPR152 p.Leu71Ile Uncertain significance Single submitter
- GPR152 p.Pro322Leu Uncertain significance Single submitter
- GPR152 p.Pro339Ser Uncertain significance Single submitter
- GPR152 p.Pro366Ala Uncertain significance Single submitter
- GPR152 p.Pro398Ala Uncertain significance Single submitter
- GPR152 p.Pro417Ser Uncertain significance Single submitter
- GPR152 p.Pro437Ala Uncertain significance Single submitter
- GPR152 p.Pro439Leu Uncertain significance Single submitter
- GPR152 p.Pro465Leu Uncertain significance Single submitter
- GPR152 p.Ser311Leu Uncertain significance Single submitter
- GPR152 p.Ser350Leu Uncertain significance Single submitter
- GPR152 p.Ser368Leu Uncertain significance Single submitter
- GPR152 p.Ser368Thr Uncertain significance Single submitter
- GPR152 p.Ser435Leu Uncertain significance Single submitter
- GPR152 p.Thr64Met Uncertain significance Single submitter
- GPR152 p.Val113Ala Uncertain significance Single submitter
- GPR152 p.Val164Met Uncertain significance Single submitter
- GPR152 p.Val174Ile Uncertain significance Single submitter
- GPR152 p.Val210Ile Uncertain significance Single submitter
- GPR152 p.Val213Ala Uncertain significance Single submitter
- GPR152 p.Val412Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- GPR152 p.Ala67Glu Uncertain significance Single submitter
- GPR152 p.Gln254Lys Uncertain significance Single submitter
- GPR152 p.Glu190Lys Uncertain significance Single submitter
- GPR152 p.Glu197Asp Uncertain significance Single submitter
- GPR152 p.Ile242Ser Uncertain significance Single submitter
- GPR152 p.Leu158Pro Likely benign Single submitter
- GPR152 p.Leu290Phe Uncertain significance Single submitter
- GPR152 p.Pro398Gln Uncertain significance Single submitter
- GPR152 p.Val151Phe Uncertain significance Single submitter
- GPR152 p.Val247Gly Uncertain significance Single submitter
All GPR152 variants
Likely benign 13
- p.Arg221His Single submitter
- p.Arg367Gln Single submitter
- p.Asp385Asn Single submitter
- p.Asp444Asn Single submitter
- p.Gln228Arg Single submitter
- p.Gly466Ser Single submitter
- p.His60Gln Single submitter
- p.Leu158Pro Single submitter ⚠
- p.Met345Thr Single submitter
- p.Pro16= Single submitter
- p.Ser269Pro Single submitter
- p.Ser435Thr Single submitter
- p.Val267Ile Single submitter
Uncertain significance 62
- p.Ala124Thr Single submitter ⚠
- p.Ala133Val Single submitter ⚠
- p.Ala153Thr Single submitter ⚠
- p.Ala217Thr Single submitter ⚠
- p.Ala230Glu Single submitter ⚠
- p.Ala231Pro Single submitter ⚠
- p.Ala236Asp Single submitter ⚠
- p.Ala314Thr Single submitter ⚠
- p.Ala346Glu Single submitter ⚠
- p.Ala441Thr Single submitter ⚠
- p.Ala450Thr Single submitter ⚠
- p.Ala467Glu Single submitter ⚠
- p.Ala54Val Single submitter ⚠
- p.Ala67Glu Single submitter ⚠
- p.Arg105Cys Single submitter
- p.Arg17Cys Single submitter ⚠
- p.Arg17His Single submitter ⚠
- p.Arg237Cys Single submitter ⚠
- p.Arg237His Single submitter ⚠
- p.Arg321Trp Single submitter ⚠
- p.Arg65Cys Single submitter ⚠
- p.Arg92Trp Single submitter ⚠
- p.Asp178Asn Single submitter ⚠
- p.Asp178Gly Single submitter ⚠
- p.Asp301Asn Single submitter ⚠
- p.Asp301His Single submitter ⚠
- p.Asp401Ala Single submitter ⚠
- p.Gln254Lys Single submitter ⚠
- p.Glu190Lys Single submitter ⚠
- p.Glu197Asp Single submitter ⚠
- p.Glu19Asp Single submitter ⚠
- p.Gly112Ser Single submitter ⚠
- p.Gly118Ser Single submitter ⚠
- p.Gly154Ser Single submitter ⚠
- p.His224Leu Single submitter ⚠
- p.Ile242Ser Single submitter ⚠
- p.Leu290Phe Single submitter ⚠
- p.Leu71Ile Single submitter ⚠
- p.Leu89Pro Single submitter
- p.Pro322Leu Single submitter ⚠
- p.Pro339Ser Single submitter ⚠
- p.Pro366Ala Single submitter ⚠
- p.Pro398Ala Single submitter ⚠
- p.Pro398Gln Single submitter ⚠
- p.Pro417Ser Single submitter ⚠
- p.Pro437Ala Single submitter ⚠
- p.Pro439Leu Single submitter ⚠
- p.Pro465Leu Single submitter ⚠
- p.Ser311Leu Single submitter ⚠
- p.Ser350Leu Single submitter ⚠
- p.Ser368Leu Single submitter ⚠
- p.Ser368Thr Single submitter ⚠
- p.Ser435Leu Single submitter ⚠
- p.Thr64Met Single submitter ⚠
- p.Val113Ala Single submitter ⚠
- p.Val151Phe Single submitter ⚠
- p.Val164Met Single submitter ⚠
- p.Val174Ile Single submitter ⚠
- p.Val210Ile Single submitter ⚠
- p.Val213Ala Single submitter ⚠
- p.Val247Gly Single submitter ⚠
- p.Val412Ile Single submitter ⚠