GPR17 — 71 ClinVar variants
All ClinVar germline GPR17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
2 Benign · 11 Likely benign · 58 Uncertain significance
Full GPR17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR17 c.-18T>C Uncertain significance Single submitter
- GPR17 p.Ala117Thr Uncertain significance Single submitter
- GPR17 p.Ala164Asp Uncertain significance Single submitter
- GPR17 p.Ala307Thr Uncertain significance Single submitter
- GPR17 p.Ala35Thr Uncertain significance Single submitter
- GPR17 p.Ala7Val Uncertain significance Single submitter
- GPR17 p.Arg129His Uncertain significance Single submitter
- GPR17 p.Arg186Gln Uncertain significance Single submitter
- GPR17 p.Arg186Trp Uncertain significance Single submitter
- GPR17 p.Arg217His Uncertain significance Single submitter
- GPR17 p.Arg220Trp Uncertain significance Single submitter
- GPR17 p.Arg228His Uncertain significance Single submitter
- GPR17 p.Arg235Cys Uncertain significance Single submitter
- GPR17 p.Arg280Cys Uncertain significance Single submitter
- GPR17 p.Arg58Gln Uncertain significance Single submitter
- GPR17 p.Arg87Cys Uncertain significance Single submitter
- GPR17 p.Asn67Ser Uncertain significance Single submitter
- GPR17 p.Asp77Gly Uncertain significance Single submitter
- GPR17 p.Cys104Gly Uncertain significance Single submitter
- GPR17 p.Gln174Lys Uncertain significance Single submitter
- GPR17 p.Glu226Asp Uncertain significance Single submitter
- GPR17 p.Gly266Glu Uncertain significance Single submitter
- GPR17 p.Gly314Ser Uncertain significance Single submitter
- GPR17 p.Gly3Ser Uncertain significance Single submitter
- GPR17 p.His149Tyr Uncertain significance Single submitter
- GPR17 p.His252Tyr Uncertain significance Single submitter
- GPR17 p.His60Leu Uncertain significance Single submitter
- GPR17 p.Leu110Phe Uncertain significance Single submitter
- GPR17 p.Leu17Val Uncertain significance Single submitter
- GPR17 p.Leu333Met Uncertain significance Single submitter
- GPR17 p.Met163Leu Uncertain significance Single submitter
- GPR17 p.Met32Lys Uncertain significance Single submitter
- GPR17 p.Phe99Ser Uncertain significance Single submitter
- GPR17 p.Pro165Leu Uncertain significance Single submitter
- GPR17 p.Pro204Leu Uncertain significance Single submitter
- GPR17 p.Ser126Arg Uncertain significance Single submitter
- GPR17 p.Ser332Leu Uncertain significance Single submitter
- GPR17 p.Ser36Ala Uncertain significance Single submitter
- GPR17 p.Thr178Met Uncertain significance Single submitter
- GPR17 p.Val168Ala Uncertain significance Single submitter
- GPR17 p.Val209Ile Uncertain significance Single submitter
- GPR17 p.Val249Met Uncertain significance Single submitter
- GPR17 p.Val253Ile Uncertain significance Single submitter
- GPR17 p.Val259Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- GPR17 p.Thr27Met Benign Multiple submitters
- GPR17 p.Ala301Val Uncertain significance Single submitter
- GPR17 p.Arg144Ser Uncertain significance Single submitter
- GPR17 p.Arg255His Uncertain significance Single submitter
- GPR17 p.Arg263Cys Uncertain significance Single submitter
- GPR17 p.Arg273Cys Uncertain significance Single submitter
- GPR17 p.Asn95Lys Uncertain significance Single submitter
- GPR17 p.Ile216Thr Uncertain significance Single submitter
- GPR17 p.Phe37Ser Uncertain significance Single submitter
- GPR17 p.Pro145Leu Uncertain significance Single submitter
- GPR17 p.Tyr120His Uncertain significance Single submitter
- GPR17 p.Val240Met Uncertain significance Single submitter
All GPR17 variants
Benign 2
- p.Thr178= Multiple submitters
- p.Thr27Met Multiple submitters ⚠
Likely benign 11
- c.-20-20T>C Single submitter
- p.Ala242= Single submitter
- p.Glu21= Single submitter
- p.Gly10Ser Single submitter
- p.Leu308= Single submitter
- p.Phe15Leu Single submitter
- p.Phe324= Single submitter
- p.Ser256= Single submitter
- p.Thr19= Single submitter
- p.Tyr147= Single submitter
- p.Val81Met Single submitter
Uncertain significance 58
- c.-18T>C Single submitter ⚠
- p.Ala117Thr Single submitter ⚠
- p.Ala164Asp Single submitter ⚠
- p.Ala301Val Single submitter ⚠
- p.Ala307Thr Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Arg105His Single submitter
- p.Arg129His Single submitter ⚠
- p.Arg144Ser Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg186Trp Single submitter ⚠
- p.Arg217His Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg228His Single submitter ⚠
- p.Arg235Cys Single submitter ⚠
- p.Arg255His Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg273Cys Single submitter ⚠
- p.Arg280Cys Single submitter ⚠
- p.Arg280His Single submitter
- p.Arg58Gln Single submitter ⚠
- p.Arg87Cys Single submitter ⚠
- p.Asn67Ser Single submitter ⚠
- p.Asn95Lys Single submitter ⚠
- p.Asp77Gly Single submitter ⚠
- p.Cys104Gly Single submitter ⚠
- p.Gln174Lys Single submitter ⚠
- p.Glu226Asp Single submitter ⚠
- p.Gly266Glu Single submitter ⚠
- p.Gly314Ser Single submitter ⚠
- p.Gly3Ser Single submitter ⚠
- p.His149Tyr Single submitter ⚠
- p.His252Tyr Single submitter ⚠
- p.His60Leu Single submitter ⚠
- p.Ile216Thr Single submitter ⚠
- p.Leu110Phe Single submitter ⚠
- p.Leu17Val Single submitter ⚠
- p.Leu275Pro Single submitter
- p.Leu333Met Single submitter ⚠
- p.Met163Leu Single submitter ⚠
- p.Met32Lys Single submitter ⚠
- p.Phe37Ser Single submitter ⚠
- p.Phe99Ser Single submitter ⚠
- p.Pro145Leu Single submitter ⚠
- p.Pro165Leu Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Ser126Arg Single submitter ⚠
- p.Ser332Leu Single submitter ⚠
- p.Ser36Ala Single submitter ⚠
- p.Thr178Met Single submitter ⚠
- p.Tyr120His Single submitter ⚠
- p.Val168Ala Single submitter ⚠
- p.Val209Ile Single submitter ⚠
- p.Val240Met Single submitter ⚠
- p.Val249Met Single submitter ⚠
- p.Val253Ile Single submitter ⚠
- p.Val259Met Single submitter ⚠