GPR180 — 51 ClinVar variants
All ClinVar germline GPR180 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
6 Benign · 6 Likely benign · 39 Uncertain significance
Full GPR180 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPR180 p.Ala127Gly Uncertain significance Single submitter
- GPR180 p.Ala291Glu Uncertain significance Single submitter
- GPR180 p.Ala334Thr Uncertain significance Single submitter
- GPR180 p.Arg437Cys Uncertain significance Single submitter
- GPR180 p.Arg437His Uncertain significance Single submitter
- GPR180 p.Asn110His Uncertain significance Single submitter
- GPR180 p.Gly200Arg Uncertain significance Single submitter
- GPR180 p.Gly323Glu Uncertain significance Single submitter
- GPR180 p.Gly3Ala Uncertain significance Single submitter
- GPR180 p.Gly3Val Uncertain significance Single submitter
- GPR180 p.His313Asn Uncertain significance Single submitter
- GPR180 p.Ile144Thr Uncertain significance Single submitter
- GPR180 p.Ile294Val Uncertain significance Single submitter
- GPR180 p.Ile365Met Uncertain significance Single submitter
- GPR180 p.Ile380Val Uncertain significance Single submitter
- GPR180 p.Leu100Trp Uncertain significance Single submitter
- GPR180 p.Leu256Phe Uncertain significance Single submitter
- GPR180 p.Leu53Phe Uncertain significance Single submitter
- GPR180 p.Met148Val Uncertain significance Single submitter
- GPR180 p.Met264Leu Uncertain significance Single submitter
- GPR180 p.Met402Thr Uncertain significance Single submitter
- GPR180 p.Pro117Ser Uncertain significance Single submitter
- GPR180 p.Pro159Thr Uncertain significance Single submitter
- GPR180 p.Ser228Cys Uncertain significance Single submitter
- GPR180 p.Ser228Phe Uncertain significance Single submitter
- GPR180 p.Ser85Asn Uncertain significance Single submitter
- GPR180 p.Thr211Ala Uncertain significance Single submitter
- GPR180 p.Trp79Arg Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- GPR180 p.Gly169Val Uncertain significance Single submitter
- GPR180 p.Gly39Asp Uncertain significance Single submitter
- GPR180 p.Lys362Glu Uncertain significance Single submitter
- GPR180 p.Phe307Leu Uncertain significance Single submitter
- GPR180 p.Ser350Arg Uncertain significance Single submitter
- GPR180 p.Ser422Cys Uncertain significance Single submitter
- GPR180 p.Ser96Pro Uncertain significance Single submitter
- GPR180 p.Val424Leu Uncertain significance Single submitter
All GPR180 variants
Benign 6
- p.Ala155= No assertion criteria GPR180-related disorder
- p.Asp309Gly No assertion criteria GPR180-related disorder
- p.Met271Ile No assertion criteria GPR180-related disorder
- p.Pro153= No assertion criteria GPR180-related disorder
- p.Ser350Asn No assertion criteria GPR180-related disorder
- p.Thr284= No assertion criteria GPR180-related disorder
Likely benign 6
- p.Met296Ile Single submitter
- p.Ser382Asn Single submitter
- c.145+9G>C No assertion criteria GPR180-related disorder
- p.Gln385= No assertion criteria GPR180-related disorder
- p.Leu192= No assertion criteria GPR180-related disorder
- p.Thr107= No assertion criteria GPR180-related disorder
Uncertain significance 39
- p.Ala127Gly Single submitter ⚠
- p.Ala291Glu Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Arg437Cys Single submitter ⚠
- p.Arg437His Single submitter ⚠
- p.Asn110His Single submitter ⚠
- p.Gly169Val Single submitter ⚠
- p.Gly200Arg Single submitter ⚠
- p.Gly241Glu Single submitter
- p.Gly323Glu Single submitter ⚠
- p.Gly39Asp Single submitter ⚠
- p.Gly3Ala Single submitter ⚠
- p.Gly3Val Single submitter ⚠
- p.His226Tyr Single submitter
- p.His313Asn Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile294Val Single submitter ⚠
- p.Ile365Met Single submitter ⚠
- p.Ile380Val Single submitter ⚠
- p.Leu100Trp Single submitter ⚠
- p.Leu256Phe Single submitter ⚠
- p.Leu53Phe Single submitter ⚠
- p.Lys362Glu Single submitter ⚠
- p.Met148Val Single submitter ⚠
- p.Met264Leu Single submitter ⚠
- p.Met402Thr Single submitter ⚠
- p.Phe307Leu Single submitter ⚠
- p.Pro117Ser Single submitter ⚠
- p.Pro159Thr Single submitter ⚠
- p.Ser228Cys Single submitter ⚠
- p.Ser228Phe Single submitter ⚠
- p.Ser231Phe Single submitter
- p.Ser350Arg Single submitter ⚠
- p.Ser422Cys Single submitter ⚠
- p.Ser85Asn Single submitter ⚠
- p.Ser96Pro Single submitter ⚠
- p.Thr211Ala Single submitter ⚠
- p.Trp79Arg Single submitter ⚠
- p.Val424Leu Single submitter ⚠