GPX8 — 31 ClinVar variants
All ClinVar germline GPX8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
1 Benign · 2 Likely benign · 28 Uncertain significance
Full GPX8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GPX8 p.Ala126Pro Uncertain significance Single submitter
- GPX8 p.Arg191Gly Uncertain significance Single submitter
- GPX8 p.Asn74Lys Uncertain significance Single submitter
- GPX8 p.Gln80Arg Uncertain significance Single submitter
- GPX8 p.Glu123Ala Uncertain significance Single submitter
- GPX8 p.Glu146Lys Uncertain significance Single submitter
- GPX8 p.Glu174Gln Uncertain significance Single submitter
- GPX8 p.Gly13Arg Uncertain significance Single submitter
- GPX8 p.Gly67Val Uncertain significance Single submitter
- GPX8 p.His138Gln Uncertain significance Single submitter
- GPX8 p.Lys56Arg Uncertain significance Single submitter
- GPX8 p.Lys64Asn Uncertain significance Single submitter
- GPX8 p.Lys90Arg Uncertain significance Single submitter
- GPX8 p.Phe125Ser Uncertain significance Single submitter
- GPX8 p.Phe33Leu Uncertain significance Single submitter
- GPX8 p.Pro107Leu Uncertain significance Single submitter
- GPX8 p.Pro14Leu Uncertain significance Single submitter
- GPX8 p.Ser124Thr Uncertain significance Single submitter
- GPX8 p.Tyr169Asp Uncertain significance Single submitter
- GPX8 p.Val122Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- GPX8 p.Arg152Ile Uncertain significance Single submitter
- GPX8 p.Arg191Ser Uncertain significance Single submitter
- GPX8 p.Ile202Ser Uncertain significance Single submitter
- GPX8 p.Pro116Leu Uncertain significance Single submitter
- GPX8 p.Ser124Cys Uncertain significance Single submitter
- GPX8 p.Ser61Tyr Uncertain significance Single submitter
- GPX8 p.Thr29Pro Uncertain significance Single submitter
All GPX8 variants
Benign 1
- p.Arg117= Multiple submitters
Likely benign 2
- p.Ile25Met Single submitter
- p.Thr31Met Single submitter
Uncertain significance 28
- p.Ala126Pro Single submitter ⚠
- p.Arg152Ile Single submitter ⚠
- p.Arg191Gly Single submitter ⚠
- p.Arg191Ser Single submitter ⚠
- p.Asn74Lys Single submitter ⚠
- p.Gln80Arg Single submitter ⚠
- p.Glu123Ala Single submitter ⚠
- p.Glu146Lys Single submitter ⚠
- p.Glu174Gln Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly67Val Single submitter ⚠
- p.His138Gln Single submitter ⚠
- p.Ile202Ser Single submitter ⚠
- p.Lys56Arg Single submitter ⚠
- p.Lys64Asn Single submitter ⚠
- p.Lys90Arg Single submitter ⚠
- p.Phe125Ser Single submitter ⚠
- p.Phe33Leu Single submitter ⚠
- p.Pro107Leu Single submitter ⚠
- p.Pro116Leu Single submitter ⚠
- p.Pro14Leu Single submitter ⚠
- p.Ser124Cys Single submitter ⚠
- p.Ser124Thr Single submitter ⚠
- p.Ser61Tyr Single submitter ⚠
- p.Thr29Pro Single submitter ⚠
- p.Tyr130Cys Single submitter
- p.Tyr169Asp Single submitter ⚠
- p.Val122Ala Single submitter ⚠