GTPBP10 — 48 ClinVar variants
All ClinVar germline GTPBP10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Likely benign · 46 Uncertain significance
Full GTPBP10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GTPBP10 p.Arg24Gly Uncertain significance Single submitter
- GTPBP10 p.Arg64Trp Uncertain significance Single submitter
- GTPBP10 p.Asn113Asp Uncertain significance Single submitter
- GTPBP10 p.Asn158Ser Uncertain significance Single submitter
- GTPBP10 p.Asp87Asn Uncertain significance Single submitter
- GTPBP10 p.Gln349Glu Uncertain significance Single submitter
- GTPBP10 p.Gln57Leu Uncertain significance Single submitter
- GTPBP10 p.Glu252Gln Uncertain significance Single submitter
- GTPBP10 p.Glu307Ala Uncertain significance Single submitter
- GTPBP10 p.Gly26Arg Uncertain significance Single submitter
- GTPBP10 p.Gly85Arg Uncertain significance Single submitter
- GTPBP10 p.His3Pro Uncertain significance Single submitter
- GTPBP10 p.Ile190Leu Uncertain significance Single submitter
- GTPBP10 p.Ile254Val Uncertain significance Single submitter
- GTPBP10 p.Ile332Met Uncertain significance Single submitter
- GTPBP10 p.Ile339Val Uncertain significance Single submitter
- GTPBP10 p.Leu203His Uncertain significance Single submitter
- GTPBP10 p.Leu203Ile Uncertain significance Single submitter
- GTPBP10 p.Leu261Met Uncertain significance Single submitter
- GTPBP10 p.Leu343Val Uncertain significance Single submitter
- GTPBP10 p.Lys104Asn Uncertain significance Single submitter
- GTPBP10 p.Lys59Asn Uncertain significance Single submitter
- GTPBP10 p.Lys84Arg Uncertain significance Single submitter
- GTPBP10 p.Lys84Glu Uncertain significance Single submitter
- GTPBP10 p.Met293Val Uncertain significance Single submitter
- GTPBP10 p.Pro204Leu Uncertain significance Single submitter
- GTPBP10 p.Ser193Gly Uncertain significance Single submitter
- GTPBP10 p.Ser199Leu Uncertain significance Single submitter
- GTPBP10 p.Ser243Phe Uncertain significance Single submitter
- GTPBP10 p.Ser83Phe Uncertain significance Single submitter
- GTPBP10 p.Thr129Ile Uncertain significance Single submitter
- GTPBP10 p.Thr245Ala Uncertain significance Single submitter
- GTPBP10 p.Thr258Arg Uncertain significance Single submitter
- GTPBP10 p.Val92Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- GTPBP10 p.Ala49Val Uncertain significance Single submitter
- GTPBP10 p.Asp114Gly Uncertain significance Single submitter
- GTPBP10 p.His218Arg Uncertain significance Single submitter
- GTPBP10 p.Lys59Glu Uncertain significance Single submitter
- GTPBP10 p.Met30Ile Uncertain significance Single submitter
- GTPBP10 p.Phe131Cys Uncertain significance Single submitter
- GTPBP10 p.Phe318Leu Uncertain significance Single submitter
- GTPBP10 p.Pro283Ala Uncertain significance Single submitter
- GTPBP10 p.Pro323Leu Uncertain significance Single submitter
- GTPBP10 p.Val327Asp Uncertain significance Single submitter
All GTPBP10 variants
Likely benign 2
- p.Arg64Gln Single submitter
- p.Ser193Asn Single submitter
Uncertain significance 46
- p.Ala49Val Single submitter ⚠
- p.Arg24Gly Single submitter ⚠
- p.Arg64Trp Single submitter ⚠
- p.Asn113Asp Single submitter ⚠
- p.Asn158Ser Single submitter ⚠
- p.Asp114Gly Single submitter ⚠
- p.Asp87Asn Single submitter ⚠
- p.Gln349Glu Single submitter ⚠
- p.Gln57Leu Single submitter ⚠
- p.Glu252Gln Single submitter ⚠
- p.Glu307Ala Single submitter ⚠
- p.Gly26Arg Single submitter ⚠
- p.Gly28Ser Single submitter
- p.Gly43Ser Single submitter
- p.Gly85Arg Single submitter ⚠
- p.His218Arg Single submitter ⚠
- p.His3Pro Single submitter ⚠
- p.Ile190Leu Single submitter ⚠
- p.Ile254Val Single submitter ⚠
- p.Ile332Met Single submitter ⚠
- p.Ile339Val Single submitter ⚠
- p.Leu203His Single submitter ⚠
- p.Leu203Ile Single submitter ⚠
- p.Leu261Met Single submitter ⚠
- p.Leu343Val Single submitter ⚠
- p.Lys104Asn Single submitter ⚠
- p.Lys59Asn Single submitter ⚠
- p.Lys59Glu Single submitter ⚠
- p.Lys84Arg Single submitter ⚠
- p.Lys84Glu Single submitter ⚠
- p.Met293Val Single submitter ⚠
- p.Met30Ile Single submitter ⚠
- p.Phe131Cys Single submitter ⚠
- p.Phe318Leu Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Pro283Ala Single submitter ⚠
- p.Pro323Leu Single submitter ⚠
- p.Ser193Gly Single submitter ⚠
- p.Ser199Leu Single submitter ⚠
- p.Ser243Phe Single submitter ⚠
- p.Ser83Phe Single submitter ⚠
- p.Thr129Ile Single submitter ⚠
- p.Thr245Ala Single submitter ⚠
- p.Thr258Arg Single submitter ⚠
- p.Val327Asp Single submitter ⚠
- p.Val92Ala Single submitter ⚠