H1-10 — 31 ClinVar variants
All ClinVar germline H1-10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
31 Uncertain significance
Full H1-10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- H1-10 p.Ala136Pro Uncertain significance Single submitter
- H1-10 p.Ala136Thr Uncertain significance Single submitter
- H1-10 p.Ala141Thr Uncertain significance Single submitter
- H1-10 p.Ala144Val Uncertain significance Single submitter
- H1-10 p.Ala148Ser Uncertain significance Single submitter
- H1-10 p.Ala14Val Uncertain significance Single submitter
- H1-10 p.Ala151Thr Uncertain significance Single submitter
- H1-10 p.Ala152Thr Uncertain significance Single submitter
- H1-10 p.Ala152Val Uncertain significance Single submitter
- H1-10 p.Ala178Thr Uncertain significance Single submitter
- H1-10 p.Ala191Val Uncertain significance Single submitter
- H1-10 p.Ala8Val Uncertain significance Single submitter
- H1-10 p.Arg156Leu Uncertain significance Single submitter
- H1-10 p.Arg36Lys Uncertain significance Single submitter
- H1-10 p.Arg58Gly Uncertain significance Single submitter
- H1-10 p.Gly175Val Uncertain significance Single submitter
- H1-10 p.Gly184Val Uncertain significance Single submitter
- H1-10 p.His172Arg Uncertain significance Single submitter
- H1-10 p.Leu5Phe Uncertain significance Single submitter
- H1-10 p.Lys115Arg Uncertain significance Single submitter
- H1-10 p.Lys180Arg Uncertain significance Single submitter
- H1-10 p.Met17Leu Uncertain significance Single submitter
- H1-10 p.Pro149Ser Uncertain significance Single submitter
- H1-10 p.Pro32Ser Uncertain significance Single submitter
- H1-10 p.Ser33Pro Uncertain significance Single submitter
- H1-10 p.Thr135Ala Uncertain significance Single submitter
- H1-10 p.Thr140Pro Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All H1-10 variants
Uncertain significance 31
- p.Ala136Pro Single submitter ⚠
- p.Ala136Thr Single submitter ⚠
- p.Ala141Thr Single submitter ⚠
- p.Ala144Val Single submitter ⚠
- p.Ala148Ser Single submitter ⚠
- p.Ala14Val Single submitter ⚠
- p.Ala151Thr Single submitter ⚠
- p.Ala152Thr Single submitter ⚠
- p.Ala152Val Single submitter ⚠
- p.Ala178Thr Single submitter ⚠
- p.Ala191Val Single submitter ⚠
- p.Ala74Gly Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg156Leu Single submitter ⚠
- p.Arg36Lys Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Arg58Gly Single submitter ⚠
- p.Gly175Val Single submitter ⚠
- p.Gly184Val Single submitter ⚠
- p.His172Arg Single submitter ⚠
- p.Leu5Phe Single submitter ⚠
- p.Lys115Arg Single submitter ⚠
- p.Lys180Arg Single submitter ⚠
- p.Lys42Asn Single submitter ⚠
- p.Met17Leu Single submitter ⚠
- p.Pro149Ser Single submitter ⚠
- p.Pro32Ser Single submitter ⚠
- p.Ser154Cys Single submitter ⚠
- p.Ser33Pro Single submitter ⚠
- p.Thr135Ala Single submitter ⚠
- p.Thr140Pro Single submitter ⚠