HCN3 — 112 ClinVar variants
All ClinVar germline HCN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 107 flagged for review →
3 Likely benign · 109 Uncertain significance
Full HCN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 107
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 91
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HCN3 p.Trp326Cys Uncertain significance Multiple submitters
- HCN3 p.Ala666Thr Uncertain significance Single submitter
- HCN3 p.Ala681Thr Uncertain significance Single submitter
- HCN3 p.Ala83Thr Uncertain significance Single submitter
- HCN3 p.Arg162Trp Uncertain significance Single submitter
- HCN3 p.Arg296His Uncertain significance Single submitter
- HCN3 p.Arg383Cys Uncertain significance Single submitter
- HCN3 p.Arg391Cys Uncertain significance Single submitter
- HCN3 p.Arg411Cys Uncertain significance Single submitter
- HCN3 p.Arg420Trp Uncertain significance Single submitter
- HCN3 p.Arg445His Uncertain significance Single submitter
- HCN3 p.Arg478His Uncertain significance Single submitter
- HCN3 p.Arg513Cys Uncertain significance Single submitter
- HCN3 p.Arg534Gln Uncertain significance Single submitter
- HCN3 p.Arg534Pro Uncertain significance Single submitter
- HCN3 p.Arg543Trp Uncertain significance Single submitter
- HCN3 p.Arg556Leu Uncertain significance Single submitter
- HCN3 p.Arg558Cys Uncertain significance Single submitter
- HCN3 p.Arg558His Uncertain significance Single submitter
- HCN3 p.Arg583Leu Uncertain significance Single submitter
- HCN3 p.Arg583Trp Uncertain significance Single submitter
- HCN3 p.Arg588Gln Uncertain significance Single submitter
- HCN3 p.Arg628Trp Uncertain significance Single submitter
- HCN3 p.Arg644His Uncertain significance Single submitter
- HCN3 p.Arg677Gln Uncertain significance Single submitter
- HCN3 p.Arg708Gln Uncertain significance Single submitter
- HCN3 p.Arg708Gly Uncertain significance Single submitter
- HCN3 p.Arg708Leu Uncertain significance Single submitter
- HCN3 p.Arg708Trp Uncertain significance Single submitter
- HCN3 p.Arg738Gln Uncertain significance Single submitter
- HCN3 p.Arg738Trp Uncertain significance Single submitter
- HCN3 p.Arg766Trp Uncertain significance Single submitter
- HCN3 p.Asn122Thr Uncertain significance Single submitter
- HCN3 p.Asn144Ser Uncertain significance Single submitter
- HCN3 p.Asn253Thr Uncertain significance Single submitter
- HCN3 p.Asp176Glu Uncertain significance Single submitter
- HCN3 p.Asp281Asn Uncertain significance Single submitter
- HCN3 p.Asp354His Uncertain significance Single submitter
- HCN3 p.Asp433Asn Uncertain significance Single submitter
- HCN3 p.Asp726Glu Uncertain significance Single submitter
- HCN3 p.Cys311Ser Uncertain significance Single submitter
- HCN3 p.Gln595Pro Uncertain significance Single submitter
- HCN3 p.Glu386Lys Uncertain significance Single submitter
- HCN3 p.Glu413Ala Uncertain significance Single submitter
- HCN3 p.Gly106Arg Uncertain significance Single submitter
- HCN3 p.Gly14Glu Uncertain significance Single submitter
- HCN3 p.Gly295Cys Uncertain significance Single submitter
- HCN3 p.Gly421Ser Uncertain significance Single submitter
- HCN3 p.Gly471Ala Uncertain significance Single submitter
- HCN3 p.Gly695Cys Uncertain significance Single submitter
- HCN3 p.Gly702Arg Uncertain significance Single submitter
- HCN3 p.Gly82Ala Uncertain significance Single submitter
- HCN3 p.His68Tyr Uncertain significance Single submitter
- HCN3 p.Ile237Phe Uncertain significance Single submitter
- HCN3 p.Ile255Thr Uncertain significance Single submitter
- HCN3 p.Ile343Val Uncertain significance Single submitter
- HCN3 p.Ile415Val Uncertain significance Single submitter
- HCN3 p.Ile547Val Uncertain significance Single submitter
- HCN3 p.Ile569Val Uncertain significance Single submitter
- HCN3 p.Leu169Arg Uncertain significance Single submitter
- HCN3 p.Leu216Pro Uncertain significance Single submitter
- HCN3 p.Leu254Ile Uncertain significance Single submitter
- HCN3 p.Met396Ile Uncertain significance Single submitter
- HCN3 p.Met465Ile Uncertain significance Single submitter
- HCN3 p.Met581Leu Uncertain significance Single submitter
- HCN3 p.Pro17Arg Uncertain significance Single submitter
- HCN3 p.Pro17Thr Uncertain significance Single submitter
- HCN3 p.Pro273Ser Uncertain significance Single submitter
- HCN3 p.Pro280Ala Uncertain significance Single submitter
- HCN3 p.Pro28Gln Uncertain significance Single submitter
- HCN3 p.Pro29Ser Uncertain significance Single submitter
- HCN3 p.Pro36Arg Uncertain significance Single submitter
- HCN3 p.Pro409Leu Uncertain significance Single submitter
- HCN3 p.Pro427Leu Uncertain significance Single submitter
- HCN3 p.Pro451Leu Uncertain significance Single submitter
- HCN3 p.Pro590Leu Uncertain significance Single submitter
- HCN3 p.Pro600Ser Uncertain significance Single submitter
- HCN3 p.Pro696Thr Uncertain significance Single submitter
- HCN3 p.Pro697Ser Uncertain significance Single submitter
- HCN3 p.Pro748Arg Uncertain significance Single submitter
- HCN3 p.Pro765Ser Uncertain significance Single submitter
- HCN3 p.Ser12Arg Uncertain significance Single submitter
- HCN3 p.Ser518Ile Uncertain significance Single submitter
- HCN3 p.Thr241Asn Uncertain significance Single submitter
- HCN3 p.Val128Ile Uncertain significance Single submitter
- HCN3 p.Val25Ile Uncertain significance Single submitter
- HCN3 p.Val455Met Uncertain significance Single submitter
- HCN3 p.Val475Met Uncertain significance Single submitter
- HCN3 p.Val525Met Uncertain significance Single submitter
- HCN3 p.Val660Ile Uncertain significance Single submitter
- HCN3 p.Val78Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- HCN3 p.Arg481Trp Uncertain significance Multiple submitters
- HCN3 p.Arg165Cys Uncertain significance Single submitter
- HCN3 p.Arg167Leu Uncertain significance Single submitter
- HCN3 p.Arg411His Uncertain significance Single submitter
- HCN3 p.Arg457Cys Uncertain significance Single submitter
- HCN3 p.Arg710Cys Uncertain significance Single submitter
- HCN3 p.Glu571Lys Uncertain significance Single submitter
- HCN3 p.Gly479Ser Uncertain significance Single submitter
- HCN3 p.Lys550Asn Uncertain significance Single submitter
- HCN3 p.Met341Val Uncertain significance Single submitter
- HCN3 p.Met531Ile Uncertain significance Single submitter
- HCN3 p.Ser460Cys Uncertain significance Single submitter
- HCN3 p.Ser669Phe Uncertain significance Single submitter
- HCN3 p.Val210Leu Uncertain significance Single submitter
- HCN3 p.Val325Leu Uncertain significance Single submitter
- HCN3 p.Val440Ala Uncertain significance Single submitter
All HCN3 variants
Likely benign 3
- p.Arg688Cys Single submitter
- p.Arg6Gly Single submitter
- p.Pro28Arg Single submitter
Uncertain significance 109
- p.Arg481Trp Multiple submitters ⚠
- p.Trp326Cys Multiple submitters ⚠
- p.Ala666Thr Single submitter ⚠
- p.Ala681Thr Single submitter ⚠
- p.Ala83Thr Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg165Cys Single submitter ⚠
- p.Arg167Leu Single submitter ⚠
- p.Arg296His Single submitter ⚠
- p.Arg383Cys Single submitter ⚠
- p.Arg391Cys Single submitter ⚠
- p.Arg411Cys Single submitter ⚠
- p.Arg411His Single submitter ⚠
- p.Arg420Trp Single submitter ⚠
- p.Arg445His Single submitter ⚠
- p.Arg457Cys Single submitter ⚠
- p.Arg478His Single submitter ⚠
- p.Arg513Cys Single submitter ⚠
- p.Arg534Gln Single submitter ⚠
- p.Arg534Pro Single submitter ⚠
- p.Arg543Trp Single submitter ⚠
- p.Arg546Cys Single submitter
- p.Arg556Leu Single submitter ⚠
- p.Arg558Cys Single submitter ⚠
- p.Arg558His Single submitter ⚠
- p.Arg583Leu Single submitter ⚠
- p.Arg583Trp Single submitter ⚠
- p.Arg588Gln Single submitter ⚠
- p.Arg628Trp Single submitter ⚠
- p.Arg644His Single submitter ⚠
- p.Arg677Gln Single submitter ⚠
- p.Arg708Gln Single submitter ⚠
- p.Arg708Gly Single submitter ⚠
- p.Arg708Leu Single submitter ⚠
- p.Arg708Trp Single submitter ⚠
- p.Arg710Cys Single submitter ⚠
- p.Arg738Gln Single submitter ⚠
- p.Arg738Trp Single submitter ⚠
- p.Arg766Trp Single submitter ⚠
- p.Asn122Thr Single submitter ⚠
- p.Asn144Ser Single submitter ⚠
- p.Asn253Thr Single submitter ⚠
- p.Asp176Glu Single submitter ⚠
- p.Asp281Asn Single submitter ⚠
- p.Asp354His Single submitter ⚠
- p.Asp433Asn Single submitter ⚠
- p.Asp726Glu Single submitter ⚠
- p.Cys311Ser Single submitter ⚠
- p.Gln595Pro Single submitter ⚠
- p.Glu386Lys Single submitter ⚠
- p.Glu413Ala Single submitter ⚠
- p.Glu571Lys Single submitter ⚠
- p.Gly106Arg Single submitter ⚠
- p.Gly14Glu Single submitter ⚠
- p.Gly295Cys Single submitter ⚠
- p.Gly421Ser Single submitter ⚠
- p.Gly471Ala Single submitter ⚠
- p.Gly479Ser Single submitter ⚠
- p.Gly695Cys Single submitter ⚠
- p.Gly702Arg Single submitter ⚠
- p.Gly82Ala Single submitter ⚠
- p.His68Tyr Single submitter ⚠
- p.Ile237Phe Single submitter ⚠
- p.Ile255Thr Single submitter ⚠
- p.Ile286Thr Single submitter
- p.Ile343Val Single submitter ⚠
- p.Ile415Val Single submitter ⚠
- p.Ile547Val Single submitter ⚠
- p.Ile569Val Single submitter ⚠
- p.Leu169Arg Single submitter ⚠
- p.Leu216Pro Single submitter ⚠
- p.Leu254Ile Single submitter ⚠
- p.Lys550Asn Single submitter ⚠
- p.Met341Val Single submitter ⚠
- p.Met396Ile Single submitter ⚠
- p.Met465Ile Single submitter ⚠
- p.Met531Ile Single submitter ⚠
- p.Met581Leu Single submitter ⚠
- p.Pro17Arg Single submitter ⚠
- p.Pro17Thr Single submitter ⚠
- p.Pro273Ser Single submitter ⚠
- p.Pro280Ala Single submitter ⚠
- p.Pro28Gln Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Pro36Arg Single submitter ⚠
- p.Pro409Leu Single submitter ⚠
- p.Pro427Leu Single submitter ⚠
- p.Pro451Leu Single submitter ⚠
- p.Pro590Leu Single submitter ⚠
- p.Pro600Ser Single submitter ⚠
- p.Pro696Thr Single submitter ⚠
- p.Pro697Ser Single submitter ⚠
- p.Pro748Arg Single submitter ⚠
- p.Pro765Ser Single submitter ⚠
- p.Ser12Arg Single submitter ⚠
- p.Ser460Cys Single submitter ⚠
- p.Ser518Ile Single submitter ⚠
- p.Ser669Phe Single submitter ⚠
- p.Thr241Asn Single submitter ⚠
- p.Val128Ile Single submitter ⚠
- p.Val210Leu Single submitter ⚠
- p.Val25Ile Single submitter ⚠
- p.Val325Leu Single submitter ⚠
- p.Val440Ala Single submitter ⚠
- p.Val455Met Single submitter ⚠
- p.Val475Met Single submitter ⚠
- p.Val525Met Single submitter ⚠
- p.Val660Ile Single submitter ⚠
- p.Val78Met Single submitter ⚠