HDAC10 — 116 ClinVar variants
All ClinVar germline HDAC10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
6 Likely benign · 110 Uncertain significance
Full HDAC10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 83
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HDAC10 p.Ala157Thr Uncertain significance Single submitter
- HDAC10 p.Ala326Val Uncertain significance Single submitter
- HDAC10 p.Ala339Val Uncertain significance Single submitter
- HDAC10 p.Ala348Val Uncertain significance Single submitter
- HDAC10 p.Ala488Thr Uncertain significance Single submitter
- HDAC10 p.Ala489Asp Uncertain significance Single submitter
- HDAC10 p.Ala503Thr Uncertain significance Single submitter
- HDAC10 p.Ala521Thr Uncertain significance Single submitter
- HDAC10 p.Ala538Pro Uncertain significance Single submitter
- HDAC10 p.Ala590Thr Uncertain significance Single submitter
- HDAC10 p.Arg411Leu Uncertain significance Single submitter
- HDAC10 p.Arg453Gly Uncertain significance Single submitter
- HDAC10 p.Arg49Leu Uncertain significance Single submitter
- HDAC10 p.Arg516Trp Uncertain significance Single submitter
- HDAC10 p.Arg525Ser Uncertain significance Single submitter
- HDAC10 p.Arg532Ser Uncertain significance Single submitter
- HDAC10 p.Arg623Trp Uncertain significance Single submitter
- HDAC10 p.Asn476Lys Uncertain significance Single submitter
- HDAC10 p.Asp185Asn Uncertain significance Single submitter
- HDAC10 p.Asp519His Uncertain significance Single submitter
- HDAC10 p.Cys403Gly Uncertain significance Single submitter
- HDAC10 p.Cys663Arg Uncertain significance Single submitter
- HDAC10 p.Gln358Glu Uncertain significance Single submitter
- HDAC10 p.Gln76Arg Uncertain significance Single submitter
- HDAC10 p.Glu280Gln Uncertain significance Single submitter
- HDAC10 p.Glu535Asp Uncertain significance Single submitter
- HDAC10 p.Glu655Gln Uncertain significance Single submitter
- HDAC10 p.Glu81Lys Uncertain significance Single submitter
- HDAC10 p.Gly133Arg Uncertain significance Single submitter
- HDAC10 p.Gly143Arg Uncertain significance Single submitter
- HDAC10 p.Gly221Ser Uncertain significance Single submitter
- HDAC10 p.Gly294Ser Uncertain significance Single submitter
- HDAC10 p.Gly303Asp Uncertain significance Single submitter
- HDAC10 p.Gly376Glu Uncertain significance Single submitter
- HDAC10 p.Gly385Arg Uncertain significance Single submitter
- HDAC10 p.Gly478Cys Uncertain significance Single submitter
- HDAC10 p.Gly533Ser Uncertain significance Single submitter
- HDAC10 p.Gly602Glu Uncertain significance Single submitter
- HDAC10 p.His174Tyr Uncertain significance Single submitter
- HDAC10 p.His244Tyr Uncertain significance Single submitter
- HDAC10 p.His284Tyr Uncertain significance Single submitter
- HDAC10 p.His96Arg Uncertain significance Single submitter
- HDAC10 p.Ile421Met Uncertain significance Single submitter
- HDAC10 p.Ile430Thr Uncertain significance Single submitter
- HDAC10 p.Ile620Phe Uncertain significance Single submitter
- HDAC10 p.Leu285Pro Uncertain significance Single submitter
- HDAC10 p.Leu292Pro Uncertain significance Single submitter
- HDAC10 p.Leu340Val Uncertain significance Single submitter
- HDAC10 p.Leu50Phe Uncertain significance Single submitter
- HDAC10 p.Leu576Val Uncertain significance Single submitter
- HDAC10 p.Leu592Phe Uncertain significance Single submitter
- HDAC10 p.Met11Ile Uncertain significance Single submitter
- HDAC10 p.Met316Leu Uncertain significance Single submitter
- HDAC10 p.Met333Val Uncertain significance Single submitter
- HDAC10 p.Met470Val Uncertain significance Single submitter
- HDAC10 p.Met596Ile Uncertain significance Single submitter
- HDAC10 p.Met648Arg Uncertain significance Single submitter
- HDAC10 p.Phe205Ser Uncertain significance Single submitter
- HDAC10 p.Pro204Thr Uncertain significance Single submitter
- HDAC10 p.Pro328Arg Uncertain significance Single submitter
- HDAC10 p.Pro352Leu Uncertain significance Single submitter
- HDAC10 p.Pro374Gln Uncertain significance Single submitter
- HDAC10 p.Pro383Thr Uncertain significance Single submitter
- HDAC10 p.Pro395Arg Uncertain significance Single submitter
- HDAC10 p.Pro419Arg Uncertain significance Single submitter
- HDAC10 p.Pro547Ala Uncertain significance Single submitter
- HDAC10 p.Pro588Leu Uncertain significance Single submitter
- HDAC10 p.Pro615Arg Uncertain significance Single submitter
- HDAC10 p.Pro641Leu Uncertain significance Single submitter
- HDAC10 p.Pro97Ser Uncertain significance Single submitter
- HDAC10 p.Ser266Leu Uncertain significance Single submitter
- HDAC10 p.Ser356Thr Uncertain significance Single submitter
- HDAC10 p.Ser526Arg Uncertain significance Single submitter
- HDAC10 p.Ser56Ala Uncertain significance Single submitter
- HDAC10 p.Ser56Leu Uncertain significance Single submitter
- HDAC10 p.Ser613Cys Uncertain significance Single submitter
- HDAC10 p.Ser632Gly Uncertain significance Single submitter
- HDAC10 p.Thr12Met Uncertain significance Single submitter
- HDAC10 p.Thr422Lys Uncertain significance Single submitter
- HDAC10 p.Val150Met Uncertain significance Single submitter
- HDAC10 p.Val189Ile Uncertain significance Single submitter
- HDAC10 p.Val239Met Uncertain significance Single submitter
- HDAC10 p.Val77Ile Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- HDAC10 p.Ala103Val Uncertain significance Single submitter
- HDAC10 p.Arg104Trp Uncertain significance Single submitter
- HDAC10 p.Arg216Trp Uncertain significance Single submitter
- HDAC10 p.Arg453Trp Uncertain significance Single submitter
- HDAC10 p.Arg46Trp Uncertain significance Single submitter
- HDAC10 p.Arg496Pro Uncertain significance Single submitter
- HDAC10 p.Arg53His Uncertain significance Single submitter
- HDAC10 p.Arg598Trp Uncertain significance Single submitter
- HDAC10 p.Arg604Gly Uncertain significance Single submitter
- HDAC10 p.Asn229His Uncertain significance Single submitter
- HDAC10 p.Asn229Lys Uncertain significance Single submitter
- HDAC10 p.His164Tyr Uncertain significance Single submitter
- HDAC10 p.His583Arg Uncertain significance Single submitter
- HDAC10 p.Leu514Pro Uncertain significance Single submitter
- HDAC10 p.Lys462Glu Uncertain significance Single submitter
- HDAC10 p.Pro483Leu Uncertain significance Single submitter
- HDAC10 p.Pro97Ala Uncertain significance Single submitter
- HDAC10 p.Pro97Leu Uncertain significance Single submitter
- HDAC10 p.Ser393Tyr Uncertain significance Single submitter
- HDAC10 p.Ser500Phe Uncertain significance Single submitter
- HDAC10 p.Thr278Met Uncertain significance Single submitter
All HDAC10 variants
Likely benign 6
- p.Ala407Thr Single submitter
- p.Arg39Gln Single submitter
- p.Asp36Glu Single submitter
- p.Lys80Glu Single submitter
- p.Pro402Leu Single submitter
- p.Val168Ile Single submitter
Uncertain significance 110
- p.Ala103Val Single submitter ⚠
- p.Ala157Thr Single submitter ⚠
- p.Ala326Val Single submitter ⚠
- p.Ala339Val Single submitter ⚠
- p.Ala348Val Single submitter ⚠
- p.Ala488Thr Single submitter ⚠
- p.Ala489Asp Single submitter ⚠
- p.Ala503Thr Single submitter ⚠
- p.Ala521Thr Single submitter ⚠
- p.Ala538Pro Single submitter ⚠
- p.Ala590Thr Single submitter ⚠
- p.Arg104Trp Single submitter ⚠
- p.Arg216Trp Single submitter ⚠
- p.Arg411Leu Single submitter ⚠
- p.Arg453Gly Single submitter ⚠
- p.Arg453Trp Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg496Pro Single submitter ⚠
- p.Arg49Leu Single submitter ⚠
- p.Arg516Trp Single submitter ⚠
- p.Arg525Ser Single submitter ⚠
- p.Arg532Ser Single submitter ⚠
- p.Arg53His Single submitter ⚠
- p.Arg598Trp Single submitter ⚠
- p.Arg604Gly Single submitter ⚠
- p.Arg623Trp Single submitter ⚠
- p.Asn229His Single submitter ⚠
- p.Asn229Lys Single submitter ⚠
- p.Asn476Lys Single submitter ⚠
- p.Asp185Asn Single submitter ⚠
- p.Asp519His Single submitter ⚠
- p.Cys403Gly Single submitter ⚠
- p.Cys663Arg Single submitter ⚠
- p.Gln358Glu Single submitter ⚠
- p.Gln76Arg Single submitter ⚠
- p.Glu280Gln Single submitter ⚠
- p.Glu535Asp Single submitter ⚠
- p.Glu655Gln Single submitter ⚠
- p.Glu81Lys Single submitter ⚠
- p.Gly133Arg Single submitter ⚠
- p.Gly143Arg Single submitter ⚠
- p.Gly221Ser Single submitter ⚠
- p.Gly294Ser Single submitter ⚠
- p.Gly303Asp Single submitter ⚠
- p.Gly376Glu Single submitter ⚠
- p.Gly385Arg Single submitter ⚠
- p.Gly478Cys Single submitter ⚠
- p.Gly533Ser Single submitter ⚠
- p.Gly602Glu Single submitter ⚠
- p.His164Tyr Single submitter ⚠
- p.His174Tyr Single submitter ⚠
- p.His244Tyr Single submitter ⚠
- p.His284Tyr Single submitter ⚠
- p.His583Arg Single submitter ⚠
- p.His96Arg Single submitter ⚠
- p.His96Tyr Single submitter
- p.Ile421Met Single submitter ⚠
- p.Ile430Thr Single submitter ⚠
- p.Ile620Phe Single submitter ⚠
- p.Leu206Val Single submitter
- p.Leu285Pro Single submitter ⚠
- p.Leu292Pro Single submitter ⚠
- p.Leu340Val Single submitter ⚠
- p.Leu50Phe Single submitter ⚠
- p.Leu514Pro Single submitter ⚠
- p.Leu576Val Single submitter ⚠
- p.Leu592Phe Single submitter ⚠
- p.Lys462Glu Single submitter ⚠
- p.Met11Ile Single submitter ⚠
- p.Met316Leu Single submitter ⚠
- p.Met333Val Single submitter ⚠
- p.Met470Val Single submitter ⚠
- p.Met596Ile Single submitter ⚠
- p.Met648Arg Single submitter ⚠
- p.Phe205Ser Single submitter ⚠
- p.Pro204Thr Single submitter ⚠
- p.Pro279Thr Single submitter
- p.Pro28Thr Single submitter
- p.Pro328Arg Single submitter ⚠
- p.Pro352Leu Single submitter ⚠
- p.Pro374Gln Single submitter ⚠
- p.Pro383Thr Single submitter ⚠
- p.Pro395Arg Single submitter ⚠
- p.Pro419Arg Single submitter ⚠
- p.Pro483Leu Single submitter ⚠
- p.Pro547Ala Single submitter ⚠
- p.Pro588Leu Single submitter ⚠
- p.Pro615Arg Single submitter ⚠
- p.Pro641Leu Single submitter ⚠
- p.Pro97Ala Single submitter ⚠
- p.Pro97Leu Single submitter ⚠
- p.Pro97Ser Single submitter ⚠
- p.Ser261Leu Single submitter
- p.Ser266Leu Single submitter ⚠
- p.Ser356Thr Single submitter ⚠
- p.Ser393Tyr Single submitter ⚠
- p.Ser500Phe Single submitter ⚠
- p.Ser526Arg Single submitter ⚠
- p.Ser56Ala Single submitter ⚠
- p.Ser56Leu Single submitter ⚠
- p.Ser613Cys Single submitter ⚠
- p.Ser632Gly Single submitter ⚠
- p.Thr12Met Single submitter ⚠
- p.Thr278Met Single submitter ⚠
- p.Thr422Lys Single submitter ⚠
- p.Val150Met Single submitter ⚠
- p.Val189Ile Single submitter ⚠
- p.Val239Met Single submitter ⚠
- p.Val300Ala Single submitter
- p.Val77Ile Single submitter ⚠