HNRNPLL — 42 ClinVar variants
All ClinVar germline HNRNPLL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
42 Uncertain significance
Full HNRNPLL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HNRNPLL p.Glu213Asp Uncertain significance Multiple submitters
- HNRNPLL p.Ala316Thr Uncertain significance Single submitter
- HNRNPLL p.Ala515Val Uncertain significance Single submitter
- HNRNPLL p.Arg303Cys Uncertain significance Single submitter
- HNRNPLL p.Arg48Trp Uncertain significance Single submitter
- HNRNPLL p.Arg9Gly Uncertain significance Single submitter
- HNRNPLL p.Asp133Gly Uncertain significance Single submitter
- HNRNPLL p.Asp52Val Uncertain significance Single submitter
- HNRNPLL p.Gln62Pro Uncertain significance Single submitter
- HNRNPLL p.Glu10Lys Uncertain significance Single submitter
- HNRNPLL p.Glu37Lys Uncertain significance Single submitter
- HNRNPLL p.Glu40Lys Uncertain significance Single submitter
- HNRNPLL p.Gly39Cys Uncertain significance Single submitter
- HNRNPLL p.Gly51Ser Uncertain significance Single submitter
- HNRNPLL p.Gly55Ser Uncertain significance Single submitter
- HNRNPLL p.Gly82Arg Uncertain significance Single submitter
- HNRNPLL p.Ile138Val Uncertain significance Single submitter
- HNRNPLL p.Ile483Met Uncertain significance Single submitter
- HNRNPLL p.Ile483Thr Uncertain significance Single submitter
- HNRNPLL p.Leu25Phe Uncertain significance Single submitter
- HNRNPLL p.Lys472Glu Uncertain significance Single submitter
- HNRNPLL p.Lys71Gln Uncertain significance Single submitter
- HNRNPLL p.Phe60Cys Uncertain significance Single submitter
- HNRNPLL p.Pro8Arg Uncertain significance Single submitter
- HNRNPLL p.Pro8Ser Uncertain significance Single submitter
- HNRNPLL p.Ser148Pro Uncertain significance Single submitter
- HNRNPLL p.Ser163Leu Uncertain significance Single submitter
- HNRNPLL p.Thr27Ile Uncertain significance Single submitter
- HNRNPLL p.Thr46Met Uncertain significance Single submitter
- HNRNPLL p.Tyr291Cys Uncertain significance Single submitter
- HNRNPLL p.Val192Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- HNRNPLL p.Arg243Gln Uncertain significance Single submitter
- HNRNPLL p.Cys84Ser Uncertain significance Single submitter
- HNRNPLL p.Gln520His Uncertain significance Single submitter
- HNRNPLL p.Ile200Thr Uncertain significance Single submitter
- HNRNPLL p.Ile250Thr Uncertain significance Single submitter
- HNRNPLL p.Lys369Asn Uncertain significance Single submitter
- HNRNPLL p.Phe286Leu Uncertain significance Single submitter
- HNRNPLL p.Ser433Arg Uncertain significance Single submitter
- HNRNPLL p.Val78Leu Uncertain significance Single submitter
All HNRNPLL variants
Uncertain significance 42
- p.Glu213Asp Multiple submitters ⚠
- p.Ala316Thr Single submitter ⚠
- p.Ala515Val Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg246His Single submitter
- p.Arg303Cys Single submitter ⚠
- p.Arg48Trp Single submitter ⚠
- p.Arg9Gly Single submitter ⚠
- p.Asp133Gly Single submitter ⚠
- p.Asp52Val Single submitter ⚠
- p.Cys84Ser Single submitter ⚠
- p.Gln520His Single submitter ⚠
- p.Gln62Pro Single submitter ⚠
- p.Glu10Lys Single submitter ⚠
- p.Glu37Lys Single submitter ⚠
- p.Glu40Lys Single submitter ⚠
- p.Gly39Cys Single submitter ⚠
- p.Gly51Ser Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.Gly82Arg Single submitter ⚠
- p.Ile138Val Single submitter ⚠
- p.Ile200Thr Single submitter ⚠
- p.Ile250Thr Single submitter ⚠
- p.Ile483Met Single submitter ⚠
- p.Ile483Thr Single submitter ⚠
- p.Leu171Phe Single submitter
- p.Leu25Phe Single submitter ⚠
- p.Lys369Asn Single submitter ⚠
- p.Lys472Glu Single submitter ⚠
- p.Lys71Gln Single submitter ⚠
- p.Phe286Leu Single submitter ⚠
- p.Phe60Cys Single submitter ⚠
- p.Pro8Arg Single submitter ⚠
- p.Pro8Ser Single submitter ⚠
- p.Ser148Pro Single submitter ⚠
- p.Ser163Leu Single submitter ⚠
- p.Ser433Arg Single submitter ⚠
- p.Thr27Ile Single submitter ⚠
- p.Thr46Met Single submitter ⚠
- p.Tyr291Cys Single submitter ⚠
- p.Val192Ile Single submitter ⚠
- p.Val78Leu Single submitter ⚠