HSP90AB1 — 58 ClinVar variants
All ClinVar germline HSP90AB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
4 Benign · 1 Benign/Likely benign · 2 Likely benign · 51 Uncertain significance
Full HSP90AB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSP90AB1 p.Ala662Thr Uncertain significance Single submitter
- HSP90AB1 p.Arg221Gln Uncertain significance Single submitter
- HSP90AB1 p.Arg449Cys Uncertain significance Single submitter
- HSP90AB1 p.Arg504Gln Uncertain significance Single submitter
- HSP90AB1 p.Arg55Cys Uncertain significance Single submitter
- HSP90AB1 p.Arg82His Uncertain significance Single submitter
- HSP90AB1 p.Gln674His Uncertain significance Single submitter
- HSP90AB1 p.Glu246Lys Uncertain significance Single submitter
- HSP90AB1 p.Glu431Val Uncertain significance Single submitter
- HSP90AB1 p.Glu509Val Uncertain significance Single submitter
- HSP90AB1 p.Glu549Asp Uncertain significance Single submitter
- HSP90AB1 p.Glu555Asp Uncertain significance Single submitter
- HSP90AB1 p.Glu715Gly Uncertain significance Single submitter
- HSP90AB1 p.Glu9Gln Uncertain significance Single submitter
- HSP90AB1 p.His458Tyr Uncertain significance Single submitter
- HSP90AB1 p.Ile175Val Uncertain significance Single submitter
- HSP90AB1 p.Ile76Leu Uncertain significance Single submitter
- HSP90AB1 p.Ile99Val Uncertain significance Single submitter
- HSP90AB1 p.Lys275Arg Uncertain significance Single submitter
- HSP90AB1 p.Pro79Ser Uncertain significance Single submitter
- HSP90AB1 p.Ser468Phe Uncertain significance Single submitter
- HSP90AB1 p.Ser594Gly Uncertain significance Single submitter
- HSP90AB1 p.Thr190Ile Uncertain significance Single submitter
- HSP90AB1 p.Thr446Ala Uncertain significance Single submitter
- HSP90AB1 p.Thr514Ile Uncertain significance Single submitter
- HSP90AB1 p.Tyr484Cys Uncertain significance Single submitter
- HSP90AB1 p.Tyr485His Uncertain significance Single submitter
- HSP90AB1 p.Tyr512Cys Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- HSP90AB1 p.Ala230Thr Uncertain significance Single submitter
- HSP90AB1 p.Arg168Cys Uncertain significance Single submitter
- HSP90AB1 p.Arg168His Uncertain significance Single submitter
- HSP90AB1 p.Arg450Cys Uncertain significance Single submitter
- HSP90AB1 p.Arg506Gln Uncertain significance Single submitter
- HSP90AB1 p.Arg639Trp Uncertain significance Single submitter
- HSP90AB1 p.Arg82Cys Uncertain significance Single submitter
- HSP90AB1 p.Asp464Asn Uncertain significance Single submitter
- HSP90AB1 p.Glu246Gly Uncertain significance Single submitter
- HSP90AB1 p.Gly172Val Uncertain significance Single submitter
- HSP90AB1 p.Gly262Cys Uncertain significance Single submitter
- HSP90AB1 p.His184Arg Uncertain significance Single submitter
- HSP90AB1 p.Ile628Val Uncertain significance Single submitter
- HSP90AB1 p.Leu670Val Uncertain significance Single submitter
- HSP90AB1 p.Lys350Asn Uncertain significance Single submitter
- HSP90AB1 p.Lys552Met Uncertain significance Single submitter
- HSP90AB1 p.Ser160Cys Uncertain significance Single submitter
- HSP90AB1 p.Ser322Ala Uncertain significance Single submitter
- HSP90AB1 p.Val12Met Uncertain significance Single submitter
- HSP90AB1 p.Val253Met Uncertain significance Single submitter
- HSP90AB1 p.Val522Leu Uncertain significance Single submitter
All HSP90AB1 variants
Benign 4
Benign/Likely benign 1
- p.Leu282= Multiple submitters
Uncertain significance 51
- p.Ala230Thr Single submitter ⚠
- p.Ala662Thr Single submitter ⚠
- p.Arg168Cys Single submitter ⚠
- p.Arg168His Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg449Cys Single submitter ⚠
- p.Arg450Cys Single submitter ⚠
- p.Arg504Gln Single submitter ⚠
- p.Arg506Gln Single submitter ⚠
- p.Arg55Cys Single submitter ⚠
- p.Arg639Trp Single submitter ⚠
- p.Arg82Cys Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Asp464Asn Single submitter ⚠
- p.Gln674His Single submitter ⚠
- p.Glu246Gly Single submitter ⚠
- p.Glu246Lys Single submitter ⚠
- p.Glu431Val Single submitter ⚠
- p.Glu509Val Single submitter ⚠
- p.Glu549Asp Single submitter ⚠
- p.Glu555Asp Single submitter ⚠
- p.Glu715Gly Single submitter ⚠
- p.Glu9Gln Single submitter ⚠
- p.Gly172Val Single submitter ⚠
- p.Gly262Cys Single submitter ⚠
- p.His184Arg Single submitter ⚠
- p.His458Tyr Single submitter ⚠
- p.Ile175Val Single submitter ⚠
- p.Ile628Val Single submitter ⚠
- p.Ile76Leu Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu451Met Single submitter
- p.Leu670Val Single submitter ⚠
- p.Lys275Arg Single submitter ⚠
- p.Lys350Asn Single submitter ⚠
- p.Lys552Met Single submitter ⚠
- p.Met394Val Single submitter
- p.Pro79Ser Single submitter ⚠
- p.Ser160Cys Single submitter ⚠
- p.Ser322Ala Single submitter ⚠
- p.Ser468Phe Single submitter ⚠
- p.Ser594Gly Single submitter ⚠
- p.Thr190Ile Single submitter ⚠
- p.Thr446Ala Single submitter ⚠
- p.Thr514Ile Single submitter ⚠
- p.Tyr484Cys Single submitter ⚠
- p.Tyr485His Single submitter ⚠
- p.Tyr512Cys Single submitter ⚠
- p.Val12Met Single submitter ⚠
- p.Val253Met Single submitter ⚠
- p.Val522Leu Single submitter ⚠