HSPA1B — 25 ClinVar variants
All ClinVar germline HSPA1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
2 Likely benign · 23 Uncertain significance
Full HSPA1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSPA1B p.Ala2Val Uncertain significance Single submitter
- HSPA1B p.Ala552Thr Uncertain significance Single submitter
- HSPA1B p.Ala5Val Uncertain significance Single submitter
- HSPA1B p.Asn65Asp Uncertain significance Single submitter
- HSPA1B p.Asp572Glu Uncertain significance Single submitter
- HSPA1B p.Gly618Glu Uncertain significance Single submitter
- HSPA1B p.Gly629Glu Uncertain significance Single submitter
- HSPA1B p.Lys559Thr Uncertain significance Single submitter
- HSPA1B p.Lys628Thr Uncertain significance Single submitter
- HSPA1B p.Pro619Ser Uncertain significance Single submitter
- HSPA1B p.Ser551Asn Uncertain significance Single submitter
- HSPA1B p.Thr14Ile Uncertain significance Single submitter
- HSPA1B p.Thr38Ala Uncertain significance Single submitter
- HSPA1B p.Val577Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- HSPA1B p.Asn499Lys Uncertain significance Single submitter
- HSPA1B p.Gln156Arg Uncertain significance Single submitter
- HSPA1B p.Gly618Arg Uncertain significance Single submitter
- HSPA1B p.Gly623Arg Uncertain significance Single submitter
- HSPA1B p.Gly634Asp Uncertain significance Single submitter
- HSPA1B p.Gly634Ser Uncertain significance Single submitter
- HSPA1B p.Ile515Met Uncertain significance Single submitter
- HSPA1B p.Ser85Trp Uncertain significance Single submitter
- HSPA1B p.Thr504Ser Uncertain significance Single submitter
All HSPA1B variants
Likely benign 2
- p.Ala614Thr Single submitter
- p.Thr491Met Single submitter
Uncertain significance 23
- p.Ala2Val Single submitter ⚠
- p.Ala552Thr Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Asn499Lys Single submitter ⚠
- p.Asn65Asp Single submitter ⚠
- p.Asp572Glu Single submitter ⚠
- p.Gln156Arg Single submitter ⚠
- p.Gly618Arg Single submitter ⚠
- p.Gly618Glu Single submitter ⚠
- p.Gly623Arg Single submitter ⚠
- p.Gly629Glu Single submitter ⚠
- p.Gly634Asp Single submitter ⚠
- p.Gly634Ser Single submitter ⚠
- p.Ile515Met Single submitter ⚠
- p.Lys559Thr Single submitter ⚠
- p.Lys628Thr Single submitter ⚠
- p.Pro619Ser Single submitter ⚠
- p.Ser551Asn Single submitter ⚠
- p.Ser85Trp Single submitter ⚠
- p.Thr14Ile Single submitter ⚠
- p.Thr38Ala Single submitter ⚠
- p.Thr504Ser Single submitter ⚠
- p.Val577Ile Single submitter ⚠