HSPA4L — 105 ClinVar variants
All ClinVar germline HSPA4L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →
2 Benign · 8 Likely benign · 95 Uncertain significance
Full HSPA4L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 90
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSPA4L p.Ala138Val Uncertain significance Single submitter
- HSPA4L p.Ala311Thr Uncertain significance Single submitter
- HSPA4L p.Ala542Thr Uncertain significance Single submitter
- HSPA4L p.Arg104Gln Uncertain significance Single submitter
- HSPA4L p.Arg265His Uncertain significance Single submitter
- HSPA4L p.Arg46Gly Uncertain significance Single submitter
- HSPA4L p.Arg84Ser Uncertain significance Single submitter
- HSPA4L p.Asn448His Uncertain significance Single submitter
- HSPA4L p.Asn803Asp Uncertain significance Single submitter
- HSPA4L p.Asn803His Uncertain significance Single submitter
- HSPA4L p.Asn803Ser Uncertain significance Single submitter
- HSPA4L p.Asp139Asn Uncertain significance Single submitter
- HSPA4L p.Asp139His Uncertain significance Single submitter
- HSPA4L p.Asp506His Uncertain significance Single submitter
- HSPA4L p.Asp633Val Uncertain significance Single submitter
- HSPA4L p.Asp825Gly Uncertain significance Single submitter
- HSPA4L p.Cys376Trp Uncertain significance Single submitter
- HSPA4L p.Cys782Tyr Uncertain significance Single submitter
- HSPA4L p.Gln209Glu Uncertain significance Single submitter
- HSPA4L p.Gln762Glu Uncertain significance Single submitter
- HSPA4L p.Glu107Gln Uncertain significance Single submitter
- HSPA4L p.Glu193Asp Uncertain significance Single submitter
- HSPA4L p.Glu271Lys Uncertain significance Single submitter
- HSPA4L p.Glu548Asp Uncertain significance Single submitter
- HSPA4L p.Glu626Gln Uncertain significance Single submitter
- HSPA4L p.Glu717Asp Uncertain significance Single submitter
- HSPA4L p.Gly413Glu Uncertain significance Single submitter
- HSPA4L p.Gly666Arg Uncertain significance Single submitter
- HSPA4L p.Gly808Asp Uncertain significance Single submitter
- HSPA4L p.Gly812Val Uncertain significance Single submitter
- HSPA4L p.Gly815Arg Uncertain significance Single submitter
- HSPA4L p.Ile114Val Uncertain significance Single submitter
- HSPA4L p.Ile288Thr Uncertain significance Single submitter
- HSPA4L p.Ile340Met Uncertain significance Single submitter
- HSPA4L p.Ile340Val Uncertain significance Single submitter
- HSPA4L p.Ile39Val Uncertain significance Single submitter
- HSPA4L p.Ile550Asn Uncertain significance Single submitter
- HSPA4L p.Ile550Val Uncertain significance Single submitter
- HSPA4L p.Ile771Thr Uncertain significance Single submitter
- HSPA4L p.Ile85Phe Uncertain significance Single submitter
- HSPA4L p.Leu125Phe Uncertain significance Single submitter
- HSPA4L p.Leu263Phe Uncertain significance Single submitter
- HSPA4L p.Leu284Ile Uncertain significance Single submitter
- HSPA4L p.Leu359Phe Uncertain significance Single submitter
- HSPA4L p.Leu397Arg Uncertain significance Single submitter
- HSPA4L p.Leu568Ser Uncertain significance Single submitter
- HSPA4L p.Leu729Val Uncertain significance Single submitter
- HSPA4L p.Leu91Pro Uncertain significance Single submitter
- HSPA4L p.Lys650Gln Uncertain significance Single submitter
- HSPA4L p.Lys739Thr Uncertain significance Single submitter
- HSPA4L p.Lys801Glu Uncertain significance Single submitter
- HSPA4L p.Met120Ile Uncertain significance Single submitter
- HSPA4L p.Met526Thr Uncertain significance Single submitter
- HSPA4L p.Met607Ile Uncertain significance Single submitter
- HSPA4L p.Met713Thr Uncertain significance Single submitter
- HSPA4L p.Met810Thr Uncertain significance Single submitter
- HSPA4L p.Phe244Val Uncertain significance Single submitter
- HSPA4L p.Phe306Ile Uncertain significance Single submitter
- HSPA4L p.Phe468Ile Uncertain significance Single submitter
- HSPA4L p.Phe518Leu Uncertain significance Single submitter
- HSPA4L p.Pro195Ala Uncertain significance Single submitter
- HSPA4L p.Pro425Ser Uncertain significance Single submitter
- HSPA4L p.Pro78Ser Uncertain significance Single submitter
- HSPA4L p.Ser384Leu Uncertain significance Single submitter
- HSPA4L p.Ser409Cys Uncertain significance Single submitter
- HSPA4L p.Ser559Pro Uncertain significance Single submitter
- HSPA4L p.Ser562Leu Uncertain significance Single submitter
- HSPA4L p.Ser586Asn Uncertain significance Single submitter
- HSPA4L p.Ser98Thr Uncertain significance Single submitter
- HSPA4L p.Thr516Ser Uncertain significance Single submitter
- HSPA4L p.Thr553Lys Uncertain significance Single submitter
- HSPA4L p.Thr571Pro Uncertain significance Single submitter
- HSPA4L p.Thr58Met Uncertain significance Single submitter
- HSPA4L p.Val60Ala Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- HSPA4L p.Ala18Val Uncertain significance Single submitter
- HSPA4L p.Ala279Thr Uncertain significance Single submitter
- HSPA4L p.Asp237Glu Uncertain significance Single submitter
- HSPA4L p.Cys310Arg Uncertain significance Single submitter
- HSPA4L p.Gln669Arg Uncertain significance Single submitter
- HSPA4L p.Glu680Lys Uncertain significance Single submitter
- HSPA4L p.Glu837Lys Uncertain significance Single submitter
- HSPA4L p.Lys356Glu Uncertain significance Single submitter
- HSPA4L p.Lys792Asn Uncertain significance Single submitter
- HSPA4L p.Phe428Leu Uncertain significance Single submitter
- HSPA4L p.Pro425Leu Uncertain significance Single submitter
- HSPA4L p.Pro687Leu Uncertain significance Single submitter
- HSPA4L p.Ser20Ile Uncertain significance Single submitter
- HSPA4L p.Ser494Arg Uncertain significance Single submitter
- HSPA4L p.Ser579Arg Uncertain significance Single submitter
- HSPA4L p.Tyr400Cys Uncertain significance Single submitter
All HSPA4L variants
Likely benign 8
- p.Ala180Val Single submitter
- p.Asn807= Single submitter
- p.Cys740Tyr Single submitter
- p.Glu604= Single submitter
- p.Gly505= Single submitter
- p.Ser649Asn Single submitter
- p.Ser746Asn Single submitter
- p.Val673Ile Single submitter
Uncertain significance 95
- p.Ala138Val Single submitter ⚠
- p.Ala163Val Single submitter
- p.Ala18Val Single submitter ⚠
- p.Ala279Thr Single submitter ⚠
- p.Ala311Thr Single submitter ⚠
- p.Ala542Thr Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg265His Single submitter ⚠
- p.Arg46Gly Single submitter ⚠
- p.Arg84Ser Single submitter ⚠
- p.Asn448His Single submitter ⚠
- p.Asn803Asp Single submitter ⚠
- p.Asn803His Single submitter ⚠
- p.Asn803Ser Single submitter ⚠
- p.Asp139Asn Single submitter ⚠
- p.Asp139His Single submitter ⚠
- p.Asp237Glu Single submitter ⚠
- p.Asp506His Single submitter ⚠
- p.Asp633Val Single submitter ⚠
- p.Asp825Gly Single submitter ⚠
- p.Cys310Arg Single submitter ⚠
- p.Cys376Trp Single submitter ⚠
- p.Cys782Tyr Single submitter ⚠
- p.Gln209Glu Single submitter ⚠
- p.Gln669Arg Single submitter ⚠
- p.Gln762Glu Single submitter ⚠
- p.Glu107Gln Single submitter ⚠
- p.Glu193Asp Single submitter ⚠
- p.Glu271Lys Single submitter ⚠
- p.Glu499Ala Single submitter
- p.Glu548Asp Single submitter ⚠
- p.Glu626Gln Single submitter ⚠
- p.Glu680Lys Single submitter ⚠
- p.Glu717Asp Single submitter ⚠
- p.Glu837Lys Single submitter ⚠
- p.Gly413Glu Single submitter ⚠
- p.Gly666Arg Single submitter ⚠
- p.Gly808Asp Single submitter ⚠
- p.Gly812Val Single submitter ⚠
- p.Gly815Arg Single submitter ⚠
- p.Ile114Val Single submitter ⚠
- p.Ile288Thr Single submitter ⚠
- p.Ile340Met Single submitter ⚠
- p.Ile340Val Single submitter ⚠
- p.Ile39Val Single submitter ⚠
- p.Ile550Asn Single submitter ⚠
- p.Ile550Val Single submitter ⚠
- p.Ile771Thr Single submitter ⚠
- p.Ile85Phe Single submitter ⚠
- p.Leu125Phe Single submitter ⚠
- p.Leu263Phe Single submitter ⚠
- p.Leu284Ile Single submitter ⚠
- p.Leu359Phe Single submitter ⚠
- p.Leu397Arg Single submitter ⚠
- p.Leu568Ser Single submitter ⚠
- p.Leu729Val Single submitter ⚠
- p.Leu91Pro Single submitter ⚠
- p.Lys356Glu Single submitter ⚠
- p.Lys650Gln Single submitter ⚠
- p.Lys739Thr Single submitter ⚠
- p.Lys792Asn Single submitter ⚠
- p.Lys801Glu Single submitter ⚠
- p.Met120Ile Single submitter ⚠
- p.Met526Thr Single submitter ⚠
- p.Met607Ile Single submitter ⚠
- p.Met713Thr Single submitter ⚠
- p.Met810Thr Single submitter ⚠
- p.Phe244Val Single submitter ⚠
- p.Phe306Ile Single submitter ⚠
- p.Phe428Leu Single submitter ⚠
- p.Phe468Ile Single submitter ⚠
- p.Phe518Leu Single submitter ⚠
- p.Pro195Ala Single submitter ⚠
- p.Pro425Leu Single submitter ⚠
- p.Pro425Ser Single submitter ⚠
- p.Pro583Leu Single submitter
- p.Pro583Ser Single submitter
- p.Pro687Leu Single submitter ⚠
- p.Pro78Ser Single submitter ⚠
- p.Ser20Ile Single submitter ⚠
- p.Ser384Leu Single submitter ⚠
- p.Ser409Cys Single submitter ⚠
- p.Ser494Arg Single submitter ⚠
- p.Ser559Pro Single submitter ⚠
- p.Ser562Leu Single submitter ⚠
- p.Ser579Arg Single submitter ⚠
- p.Ser586Asn Single submitter ⚠
- p.Ser98Thr Single submitter ⚠
- p.Thr516Ser Single submitter ⚠
- p.Thr553Lys Single submitter ⚠
- p.Thr571Pro Single submitter ⚠
- p.Thr58Met Single submitter ⚠
- p.Tyr243Asp Single submitter
- p.Tyr400Cys Single submitter ⚠
- p.Val60Ala Single submitter ⚠