HSPA5 — 39 ClinVar variants
All ClinVar germline HSPA5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
3 Benign · 2 Likely benign · 34 Uncertain significance
Full HSPA5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HSPA5 p.Ala638Thr Uncertain significance Single submitter
- HSPA5 p.Arg283Lys Uncertain significance Single submitter
- HSPA5 p.Arg386Cys Uncertain significance Single submitter
- HSPA5 p.Arg49Leu Uncertain significance Single submitter
- HSPA5 p.Asp105Glu Uncertain significance Single submitter
- HSPA5 p.Asp615Val Uncertain significance Single submitter
- HSPA5 p.Asp652Glu Uncertain significance Single submitter
- HSPA5 p.Asp652Val Uncertain significance Single submitter
- HSPA5 p.Glu89Lys Uncertain significance Single submitter
- HSPA5 p.His252Arg Uncertain significance Single submitter
- HSPA5 p.Ile207Val Uncertain significance Single submitter
- HSPA5 p.Ile559Phe Uncertain significance Single submitter
- HSPA5 p.Ile613Val Uncertain significance Single submitter
- HSPA5 p.Leu634Arg Uncertain significance Single submitter
- HSPA5 p.Lys435Arg Uncertain significance Single submitter
- HSPA5 p.Lys591Gln Uncertain significance Single submitter
- HSPA5 p.Lys620Gln Uncertain significance Single submitter
- HSPA5 p.Phe318Val Uncertain significance Single submitter
- HSPA5 p.Pro106Ser Uncertain significance Single submitter
- HSPA5 p.Pro438Ser Uncertain significance Single submitter
- HSPA5 p.Pro491Leu Uncertain significance Single submitter
- HSPA5 p.Pro63Gln Uncertain significance Single submitter
- HSPA5 p.Ser587Pro Uncertain significance Single submitter
- HSPA5 p.Tyr313His Uncertain significance Single submitter
- HSPA5 p.Val149Leu Uncertain significance Single submitter
- HSPA5 p.Val195Ile Uncertain significance Single submitter
- HSPA5 p.Val342Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- HSPA5 p.Glu557Gly Benign Multiple submitters
- HSPA5 p.Arg558Cys Uncertain significance Single submitter
- HSPA5 p.Arg558His Uncertain significance Single submitter
- HSPA5 p.Glu580Gln Uncertain significance Single submitter
- HSPA5 p.Glu589Lys Uncertain significance Single submitter
- HSPA5 p.Tyr313Cys Uncertain significance Single submitter
All HSPA5 variants
Benign 3
- p.Glu557Gly Multiple submitters ⚠
- p.Asp529= Single submitter
- p.Lys601Met Single submitter
Uncertain significance 34
- p.Ala638Thr Single submitter ⚠
- p.Arg283Lys Single submitter ⚠
- p.Arg386Cys Single submitter ⚠
- p.Arg49Leu Single submitter ⚠
- p.Arg558Cys Single submitter ⚠
- p.Arg558His Single submitter ⚠
- p.Arg558Leu Single submitter
- p.Asp105Glu Single submitter ⚠
- p.Asp615Val Single submitter ⚠
- p.Asp652Glu Single submitter ⚠
- p.Asp652Val Single submitter ⚠
- p.Glu580Gln Single submitter ⚠
- p.Glu589Lys Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.His252Arg Single submitter ⚠
- p.Ile207Val Single submitter ⚠
- p.Ile559Phe Single submitter ⚠
- p.Ile613Val Single submitter ⚠
- p.Leu634Arg Single submitter ⚠
- p.Lys376Glu Single submitter
- p.Lys435Arg Single submitter ⚠
- p.Lys591Gln Single submitter ⚠
- p.Lys620Gln Single submitter ⚠
- p.Phe318Val Single submitter ⚠
- p.Pro106Ser Single submitter ⚠
- p.Pro438Ser Single submitter ⚠
- p.Pro491Leu Single submitter ⚠
- p.Pro63Gln Single submitter ⚠
- p.Ser587Pro Single submitter ⚠
- p.Tyr313Cys Single submitter ⚠
- p.Tyr313His Single submitter ⚠
- p.Val149Leu Single submitter ⚠
- p.Val195Ile Single submitter ⚠
- p.Val342Ile Single submitter ⚠