HTR1D — 68 ClinVar variants
All ClinVar germline HTR1D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
3 Benign · 1 Likely benign · 64 Uncertain significance
Full HTR1D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR1D p.Ala152Ser Uncertain significance Single submitter
- HTR1D p.Ala155Thr Uncertain significance Single submitter
- HTR1D p.Ala160Thr Uncertain significance Single submitter
- HTR1D p.Ala160Val Uncertain significance Single submitter
- HTR1D p.Ala205Val Uncertain significance Single submitter
- HTR1D p.Ala282Gly Uncertain significance Single submitter
- HTR1D p.Ala285Thr Uncertain significance Single submitter
- HTR1D p.Ala309Thr Uncertain significance Single submitter
- HTR1D p.Ala376Pro Uncertain significance Single submitter
- HTR1D p.Ala376Val Uncertain significance Single submitter
- HTR1D p.Arg222Gln Uncertain significance Single submitter
- HTR1D p.Arg222Trp Uncertain significance Single submitter
- HTR1D p.Arg225Gln Uncertain significance Single submitter
- HTR1D p.Arg238Cys Uncertain significance Single submitter
- HTR1D p.Arg238His Uncertain significance Single submitter
- HTR1D p.Arg297Ser Uncertain significance Single submitter
- HTR1D p.Arg328Gln Uncertain significance Single submitter
- HTR1D p.Arg364Gln Uncertain significance Single submitter
- HTR1D p.Asn17Asp Uncertain significance Single submitter
- HTR1D p.Asn257His Uncertain significance Single submitter
- HTR1D p.Asn56Ile Uncertain significance Single submitter
- HTR1D p.Asp118Gly Uncertain significance Single submitter
- HTR1D p.Asp329Asn Uncertain significance Single submitter
- HTR1D p.Cys168Phe Uncertain significance Single submitter
- HTR1D p.Gln365Arg Uncertain significance Single submitter
- HTR1D p.Glu296Ala Uncertain significance Single submitter
- HTR1D p.Gly10Asp Uncertain significance Single submitter
- HTR1D p.Gly250Val Uncertain significance Single submitter
- HTR1D p.His261Gln Uncertain significance Single submitter
- HTR1D p.Ile161Thr Uncertain significance Single submitter
- HTR1D p.Ile199Val Uncertain significance Single submitter
- HTR1D p.Ile208Val Uncertain significance Single submitter
- HTR1D p.Ile228Phe Uncertain significance Single submitter
- HTR1D p.Ile355Thr Uncertain significance Single submitter
- HTR1D p.Leu234Val Uncertain significance Single submitter
- HTR1D p.Leu34Phe Uncertain significance Single submitter
- HTR1D p.Lys278Thr Uncertain significance Single submitter
- HTR1D p.Lys301Arg Uncertain significance Single submitter
- HTR1D p.Phe318Leu Uncertain significance Single submitter
- HTR1D p.Phe318Val Uncertain significance Single submitter
- HTR1D p.Pro173Leu Uncertain significance Single submitter
- HTR1D p.Ser125Phe Uncertain significance Single submitter
- HTR1D p.Ser186Leu Uncertain significance Single submitter
- HTR1D p.Ser255Leu Uncertain significance Single submitter
- HTR1D p.Ser267Pro Uncertain significance Single submitter
- HTR1D p.Thr120Met Uncertain significance Single submitter
- HTR1D p.Thr151Met Uncertain significance Single submitter
- HTR1D p.Thr157Asn Uncertain significance Single submitter
- HTR1D p.Thr157Ile Uncertain significance Single submitter
- HTR1D p.Thr241Met Uncertain significance Single submitter
- HTR1D p.Thr246Pro Uncertain significance Single submitter
- HTR1D p.Tyr217Cys Uncertain significance Single submitter
- HTR1D p.Tyr235Cys Uncertain significance Single submitter
- HTR1D p.Val277Leu Uncertain significance Single submitter
- HTR1D p.Val319Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- HTR1D p.Arg328Trp Uncertain significance Single submitter
- HTR1D p.Cys168Tyr Uncertain significance Single submitter
- HTR1D p.Ile165Ser Uncertain significance Single submitter
- HTR1D p.Leu286Pro Uncertain significance Single submitter
- HTR1D p.Lys148Glu Uncertain significance Single submitter
- HTR1D p.Lys289Asn Uncertain significance Single submitter
- HTR1D p.Pro72Ala Uncertain significance Single submitter
- HTR1D p.Thr300Ile Uncertain significance Single submitter
All HTR1D variants
Benign 3
- p.Ser186= Multiple submitters
- p.Ser265Leu Multiple submitters
- p.Ala42= Single submitter
Likely benign 1
- p.Asn105Ser Single submitter
Uncertain significance 64
- p.Ala152Ser Single submitter ⚠
- p.Ala155Thr Single submitter ⚠
- p.Ala160Thr Single submitter ⚠
- p.Ala160Val Single submitter ⚠
- p.Ala205Val Single submitter ⚠
- p.Ala282Gly Single submitter ⚠
- p.Ala285Thr Single submitter ⚠
- p.Ala309Thr Single submitter ⚠
- p.Ala376Pro Single submitter ⚠
- p.Ala376Val Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg222Trp Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg227Cys Single submitter
- p.Arg238Cys Single submitter ⚠
- p.Arg238His Single submitter ⚠
- p.Arg297Ser Single submitter ⚠
- p.Arg328Gln Single submitter ⚠
- p.Arg328Trp Single submitter ⚠
- p.Arg364Gln Single submitter ⚠
- p.Asn17Asp Single submitter ⚠
- p.Asn257His Single submitter ⚠
- p.Asn56Ile Single submitter ⚠
- p.Asp118Gly Single submitter ⚠
- p.Asp329Asn Single submitter ⚠
- p.Cys168Phe Single submitter ⚠
- p.Cys168Tyr Single submitter ⚠
- p.Gln365Arg Single submitter ⚠
- p.Glu296Ala Single submitter ⚠
- p.Gly10Asp Single submitter ⚠
- p.Gly250Val Single submitter ⚠
- p.His261Gln Single submitter ⚠
- p.Ile161Thr Single submitter ⚠
- p.Ile165Ser Single submitter ⚠
- p.Ile199Val Single submitter ⚠
- p.Ile208Val Single submitter ⚠
- p.Ile228Phe Single submitter ⚠
- p.Ile355Thr Single submitter ⚠
- p.Leu234Val Single submitter ⚠
- p.Leu286Pro Single submitter ⚠
- p.Leu34Phe Single submitter ⚠
- p.Lys148Glu Single submitter ⚠
- p.Lys278Thr Single submitter ⚠
- p.Lys289Asn Single submitter ⚠
- p.Lys301Arg Single submitter ⚠
- p.Phe318Leu Single submitter ⚠
- p.Phe318Val Single submitter ⚠
- p.Pro173Leu Single submitter ⚠
- p.Pro72Ala Single submitter ⚠
- p.Ser125Phe Single submitter ⚠
- p.Ser186Leu Single submitter ⚠
- p.Ser255Leu Single submitter ⚠
- p.Ser267Pro Single submitter ⚠
- p.Thr120Met Single submitter ⚠
- p.Thr151Met Single submitter ⚠
- p.Thr157Asn Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Thr241Met Single submitter ⚠
- p.Thr246Pro Single submitter ⚠
- p.Thr300Ile Single submitter ⚠
- p.Tyr217Cys Single submitter ⚠
- p.Tyr235Cys Single submitter ⚠
- p.Val277Leu Single submitter ⚠
- p.Val319Met Single submitter ⚠