HTR2A — 41 ClinVar variants
All ClinVar germline HTR2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
3 Benign · 10 Likely benign · 28 Uncertain significance
Full HTR2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR2A p.Ala230Thr Uncertain significance Single submitter
- HTR2A p.Ala447Thr Uncertain significance Single submitter
- HTR2A p.Arg140Gln Uncertain significance Single submitter
- HTR2A p.Arg275Gln Uncertain significance Single submitter
- HTR2A p.Arg393Trp Uncertain significance Single submitter
- HTR2A p.Asp31Tyr Uncertain significance Single submitter
- HTR2A p.Asp435His Uncertain significance Single submitter
- HTR2A p.Asp462Glu Uncertain significance Single submitter
- HTR2A p.Gln313Lys Uncertain significance Single submitter
- HTR2A p.Gln425His Uncertain significance Single submitter
- HTR2A p.Glu355Lys Uncertain significance Single submitter
- HTR2A p.His452Pro Uncertain significance Single submitter
- HTR2A p.Ile3Phe Uncertain significance Single submitter
- HTR2A p.Lys400Arg Uncertain significance Single submitter
- HTR2A p.Met312Val Uncertain significance Single submitter
- HTR2A p.Phe43Ile Uncertain significance Single submitter
- HTR2A p.Phe43Val Uncertain significance Single submitter
- HTR2A p.Pro303Leu Uncertain significance Single submitter
- HTR2A p.Ser29Thr Uncertain significance Single submitter
- HTR2A p.Thr160Met Uncertain significance Single submitter
- HTR2A p.Thr307Ile Uncertain significance Single submitter
- HTR2A p.Trp76Cys Uncertain significance Single submitter
- HTR2A p.Val175Ile Uncertain significance Single submitter
- HTR2A p.Val379Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All HTR2A variants
Benign 3
- p.Ser17= Multiple submitters
- c.614-2211T>C Single submitter
- p.Leu229= Single submitter
Likely benign 10
Uncertain significance 28
- c.412+1G>C Single submitter
- p.Ala230Thr Single submitter ⚠
- p.Ala447Thr Single submitter ⚠
- p.Arg140Gln Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Arg275Gln Single submitter ⚠
- p.Arg393Trp Single submitter ⚠
- p.Asn54His Single submitter ⚠
- p.Asp31Tyr Single submitter ⚠
- p.Asp435His Single submitter ⚠
- p.Asp462Glu Single submitter ⚠
- p.Gln313Lys Single submitter ⚠
- p.Gln425His Single submitter ⚠
- p.Glu355Lys Single submitter ⚠
- p.His452Pro Single submitter ⚠
- p.Ile3Phe Single submitter ⚠
- p.Lys400Arg Single submitter ⚠
- p.Met312Val Single submitter ⚠
- p.Phe43Ile Single submitter ⚠
- p.Phe43Val Single submitter ⚠
- p.Pro303Leu Single submitter ⚠
- p.Ser29Thr Single submitter ⚠
- p.Thr160Met Single submitter ⚠
- p.Thr274Ile Single submitter ⚠
- p.Thr307Ile Single submitter ⚠
- p.Trp76Cys Single submitter ⚠
- p.Val175Ile Single submitter ⚠
- p.Val379Ala Single submitter ⚠