HTR4 — 61 ClinVar variants
All ClinVar germline HTR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
4 Benign · 5 Likely benign · 52 Uncertain significance
Full HTR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR4 p.Ala193Val Uncertain significance Single submitter
- HTR4 p.Ala273Thr Uncertain significance Single submitter
- HTR4 p.Arg137Ser Uncertain significance Single submitter
- HTR4 p.Arg173Lys Uncertain significance Single submitter
- HTR4 p.Arg231Gln Uncertain significance Single submitter
- HTR4 p.Arg250His Uncertain significance Single submitter
- HTR4 p.Arg321His Uncertain significance Single submitter
- HTR4 p.Asn176Ser Uncertain significance Single submitter
- HTR4 p.Cys364Arg Uncertain significance Single submitter
- HTR4 p.Gln177His Uncertain significance Single submitter
- HTR4 p.Glu12Gly Uncertain significance Single submitter
- HTR4 p.Glu237Lys Uncertain significance Single submitter
- HTR4 p.Gly13Arg Uncertain significance Single submitter
- HTR4 p.Gly266Asp Uncertain significance Single submitter
- HTR4 p.Gly353Ala Uncertain significance Single submitter
- HTR4 p.His356Arg Uncertain significance Single submitter
- HTR4 p.Ile215Asn Uncertain significance Single submitter
- HTR4 p.Ile263Val Uncertain significance Single submitter
- HTR4 p.Ile85Thr Uncertain significance Single submitter
- HTR4 p.Leu315Phe Uncertain significance Single submitter
- HTR4 p.Leu340Pro Uncertain significance Single submitter
- HTR4 p.Lys174Thr Uncertain significance Single submitter
- HTR4 p.Lys190Glu Uncertain significance Single submitter
- HTR4 p.Lys259Arg Uncertain significance Single submitter
- HTR4 p.Met228Ile Uncertain significance Single submitter
- HTR4 p.Met32Thr Uncertain significance Single submitter
- HTR4 p.Pro149His Uncertain significance Single submitter
- HTR4 p.Pro149Leu Uncertain significance Single submitter
- HTR4 p.Pro379Leu Uncertain significance Single submitter
- HTR4 p.Ser242Leu Uncertain significance Single submitter
- HTR4 p.Ser247Asn Uncertain significance Single submitter
- HTR4 p.Thr28Met Uncertain significance Single submitter
- HTR4 p.Thr355Ala Uncertain significance Single submitter
- HTR4 p.Thr377Pro Uncertain significance Single submitter
- HTR4 p.Tyr213Cys Uncertain significance Single submitter
- HTR4 p.Val198Ala Uncertain significance Single submitter
- HTR4 p.Val21Met Uncertain significance Single submitter
- HTR4 p.Val362Ala Uncertain significance Single submitter
- HTR4 p.Val362Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All HTR4 variants
Benign 4
- c.1077-996A>G Single submitter
- c.26+354C>A Single submitter squamous cell carcinoma
- p.Cys372Tyr Single submitter
- p.His356= Single submitter
Likely benign 5
- p.Gly15Arg Multiple submitters
- c.1077-1034G>T Single submitter
- c.26+7221G>A Single submitter lung adenocarcinoma
- p.Thr150Met Single submitter
- p.Val91Met Single submitter
Uncertain significance 52
- c.1076+211C>A Single submitter lung adenocarcinoma
- c.1077-1009C>T Single submitter
- c.1077-1019T>C Single submitter
- c.1077-1030G>C Single submitter
- c.1077-1037C>T Single submitter
- c.1077-1051G>C Single submitter
- c.1077-1060T>C Single submitter
- p.Ala193Val Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Arg137Ser Single submitter ⚠
- p.Arg173Lys Single submitter ⚠
- p.Arg214His Single submitter ⚠
- p.Arg231Gln Single submitter ⚠
- p.Arg250His Single submitter ⚠
- p.Arg321His Single submitter ⚠
- p.Arg96Trp Single submitter ⚠
- p.Asn176Ser Single submitter ⚠
- p.Asp286Tyr Single submitter ⚠
- p.Cys364Arg Single submitter ⚠
- p.Gln177His Single submitter ⚠
- p.Glu12Gly Single submitter ⚠
- p.Glu237Lys Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly266Asp Single submitter ⚠
- p.Gly353Ala Single submitter ⚠
- p.His356Arg Single submitter ⚠
- p.Ile215Asn Single submitter ⚠
- p.Ile263Val Single submitter ⚠
- p.Ile85Thr Single submitter ⚠
- p.Leu315Phe Single submitter ⚠
- p.Leu340Pro Single submitter ⚠
- p.Lys174Thr Single submitter ⚠
- p.Lys190Glu Single submitter ⚠
- p.Lys259Arg Single submitter ⚠
- p.Met208Ile Single submitter ⚠
- p.Met228Ile Single submitter ⚠
- p.Met32Thr Single submitter ⚠
- p.Pro149His Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro379Leu Single submitter ⚠
- p.Ser242Leu Single submitter ⚠
- p.Ser247Asn Single submitter ⚠
- p.Thr28Met Single submitter ⚠
- p.Thr355Ala Single submitter ⚠
- p.Thr377Pro Single submitter ⚠
- p.Tyr213Cys Single submitter ⚠
- p.Val198Ala Single submitter ⚠
- p.Val199Ala Single submitter
- p.Val21Met Single submitter ⚠
- p.Val362Ala Single submitter ⚠
- p.Val362Met Single submitter ⚠
- p.Val69Ile Single submitter ⚠