HTR7 — 56 ClinVar variants
All ClinVar germline HTR7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Benign · 1 Likely benign · 53 Uncertain significance
Full HTR7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HTR7 p.Ala168Val Uncertain significance Single submitter
- HTR7 p.Ala335Ser Uncertain significance Single submitter
- HTR7 p.Ala62Thr Uncertain significance Single submitter
- HTR7 p.Ala62Val Uncertain significance Single submitter
- HTR7 p.Arg17Cys Uncertain significance Single submitter
- HTR7 p.Arg17Leu Uncertain significance Single submitter
- HTR7 p.Arg389Trp Uncertain significance Single submitter
- HTR7 p.Arg396Cys Uncertain significance Single submitter
- HTR7 p.Arg9Gly Uncertain significance Single submitter
- HTR7 p.Asn66Ser Uncertain significance Single submitter
- HTR7 p.Asp38His Uncertain significance Single submitter
- HTR7 p.Asp465Gly Uncertain significance Single submitter
- HTR7 p.Asp479Val Uncertain significance Single submitter
- HTR7 p.Asp65Asn Uncertain significance Single submitter
- HTR7 p.Glu80Gly Uncertain significance Single submitter
- HTR7 p.Gly14Arg Uncertain significance Single submitter
- HTR7 p.His15Arg Uncertain significance Single submitter
- HTR7 p.His459Arg Uncertain significance Single submitter
- HTR7 p.Ile213Val Uncertain significance Single submitter
- HTR7 p.Leu20Phe Uncertain significance Single submitter
- HTR7 p.Leu215Ile Uncertain significance Single submitter
- HTR7 p.Leu378Phe Uncertain significance Single submitter
- HTR7 p.Leu454Val Uncertain significance Single submitter
- HTR7 p.Leu468Met Uncertain significance Single submitter
- HTR7 p.Leu48Pro Uncertain significance Single submitter
- HTR7 p.Leu88Arg Uncertain significance Single submitter
- HTR7 p.Leu90Phe Uncertain significance Single submitter
- HTR7 p.Met202Leu Uncertain significance Single submitter
- HTR7 p.Met258Leu Uncertain significance Single submitter
- HTR7 p.Met2Ile Uncertain significance Single submitter
- HTR7 p.Met415Val Uncertain significance Single submitter
- HTR7 p.Pro22Ser Uncertain significance Single submitter
- HTR7 p.Pro39Arg Uncertain significance Single submitter
- HTR7 p.Pro39Gln Uncertain significance Single submitter
- HTR7 p.Pro56Leu Uncertain significance Single submitter
- HTR7 p.Ser139Gly Uncertain significance Single submitter
- HTR7 p.Ser306Leu Uncertain significance Single submitter
- HTR7 p.Ser6Gly Uncertain significance Single submitter
- HTR7 p.Trp44Arg Uncertain significance Single submitter
- HTR7 p.Tyr239Cys Uncertain significance Single submitter
- HTR7 p.Val333Ile Uncertain significance Single submitter
- HTR7 p.Val449Ala Uncertain significance Single submitter
- HTR7 p.Val79Gly Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- HTR7 p.His416Arg Uncertain significance Single submitter
- HTR7 p.Ile120Met Uncertain significance Single submitter
- HTR7 p.Met164Thr Uncertain significance Single submitter
- HTR7 p.Met415Ile Uncertain significance Single submitter
- HTR7 p.Phe137Leu Uncertain significance Single submitter
- HTR7 p.Pro115Ser Uncertain significance Single submitter
- HTR7 p.Ser234Asn Uncertain significance Single submitter
- HTR7 p.Thr327Ile Uncertain significance Single submitter
All HTR7 variants
Benign 2
- p.Pro448Arg Multiple submitters
- p.Ala62= Single submitter
Likely benign 1
- p.Pro457Ser Single submitter
Uncertain significance 53
- p.Ala168Val Single submitter ⚠
- p.Ala335Ser Single submitter ⚠
- p.Ala62Thr Single submitter ⚠
- p.Ala62Val Single submitter ⚠
- p.Arg17Cys Single submitter ⚠
- p.Arg17Leu Single submitter ⚠
- p.Arg389Trp Single submitter ⚠
- p.Arg396Cys Single submitter ⚠
- p.Arg9Gly Single submitter ⚠
- p.Asn66Ser Single submitter ⚠
- p.Asp38His Single submitter ⚠
- p.Asp465Gly Single submitter ⚠
- p.Asp479Val Single submitter ⚠
- p.Asp65Asn Single submitter ⚠
- p.Glu80Gly Single submitter ⚠
- p.Gly14Arg Single submitter ⚠
- p.His15Arg Single submitter ⚠
- p.His416Arg Single submitter ⚠
- p.His459Arg Single submitter ⚠
- p.Ile120Met Single submitter ⚠
- p.Ile213Val Single submitter ⚠
- p.Leu20Phe Single submitter ⚠
- p.Leu215Ile Single submitter ⚠
- p.Leu378Phe Single submitter ⚠
- p.Leu454Val Single submitter ⚠
- p.Leu468Met Single submitter ⚠
- p.Leu48Pro Single submitter ⚠
- p.Leu88Arg Single submitter ⚠
- p.Leu90Phe Single submitter ⚠
- p.Met164Thr Single submitter ⚠
- p.Met202Leu Single submitter ⚠
- p.Met258Leu Single submitter ⚠
- p.Met2Ile Single submitter ⚠
- p.Met415Ile Single submitter ⚠
- p.Met415Val Single submitter ⚠
- p.Phe137Leu Single submitter ⚠
- p.Phe386Ile Single submitter
- p.Pro115Ser Single submitter ⚠
- p.Pro22Ser Single submitter ⚠
- p.Pro39Arg Single submitter ⚠
- p.Pro39Gln Single submitter ⚠
- p.Pro56Leu Single submitter ⚠
- p.Ser139Gly Single submitter ⚠
- p.Ser234Asn Single submitter ⚠
- p.Ser306Leu Single submitter ⚠
- p.Ser6Gly Single submitter ⚠
- p.Thr327Ile Single submitter ⚠
- p.Trp44Arg Single submitter ⚠
- p.Tyr239Cys Single submitter ⚠
- p.Val246Ala Single submitter
- p.Val333Ile Single submitter ⚠
- p.Val449Ala Single submitter ⚠
- p.Val79Gly Single submitter ⚠