HUNK — 98 ClinVar variants
All ClinVar germline HUNK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
5 Likely benign · 93 Uncertain significance
Full HUNK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- HUNK p.Ala272Ser Uncertain significance Single submitter
- HUNK p.Ala590Asp Uncertain significance Single submitter
- HUNK p.Ala698Gly Uncertain significance Single submitter
- HUNK p.Arg119His Uncertain significance Single submitter
- HUNK p.Arg164His Uncertain significance Single submitter
- HUNK p.Arg298His Uncertain significance Single submitter
- HUNK p.Arg318Cys Uncertain significance Single submitter
- HUNK p.Arg427Gly Uncertain significance Single submitter
- HUNK p.Arg451Gln Uncertain significance Single submitter
- HUNK p.Arg485Gln Uncertain significance Single submitter
- HUNK p.Arg485Trp Uncertain significance Single submitter
- HUNK p.Arg501His Uncertain significance Single submitter
- HUNK p.Arg567His Uncertain significance Single submitter
- HUNK p.Arg675Cys Uncertain significance Single submitter
- HUNK p.Asn321Ile Uncertain significance Single submitter
- HUNK p.Asn336Ser Uncertain significance Single submitter
- HUNK p.Asn511Ser Uncertain significance Single submitter
- HUNK p.Asn584Ile Uncertain significance Single submitter
- HUNK p.Asn655Ser Uncertain significance Single submitter
- HUNK p.Asn655Thr Uncertain significance Single submitter
- HUNK p.Asp186Asn Uncertain significance Single submitter
- HUNK p.Asp24His Uncertain significance Single submitter
- HUNK p.Asp509Tyr Uncertain significance Single submitter
- HUNK p.Asp708Asn Uncertain significance Single submitter
- HUNK p.Cys330Arg Uncertain significance Single submitter
- HUNK p.Cys372Tyr Uncertain significance Single submitter
- HUNK p.Cys637Tyr Uncertain significance Single submitter
- HUNK p.Gln53Pro Uncertain significance Single submitter
- HUNK p.Glu159Gln Uncertain significance Single submitter
- HUNK p.Glu159Lys Uncertain significance Single submitter
- HUNK p.Glu353Lys Uncertain significance Single submitter
- HUNK p.Glu572Gly Uncertain significance Single submitter
- HUNK p.Glu625Lys Uncertain significance Single submitter
- HUNK p.Gly543Arg Uncertain significance Single submitter
- HUNK p.His150Tyr Uncertain significance Single submitter
- HUNK p.His184Leu Uncertain significance Single submitter
- HUNK p.Ile189Thr Uncertain significance Single submitter
- HUNK p.Ile521Val Uncertain significance Single submitter
- HUNK p.Leu301Pro Uncertain significance Single submitter
- HUNK p.Leu389Trp Uncertain significance Single submitter
- HUNK p.Leu429Val Uncertain significance Single submitter
- HUNK p.Leu702Val Uncertain significance Single submitter
- HUNK p.Leu9Ile Uncertain significance Single submitter
- HUNK p.Lys415Arg Uncertain significance Single submitter
- HUNK p.Lys455Glu Uncertain significance Single submitter
- HUNK p.Lys465Asn Uncertain significance Single submitter
- HUNK p.Lys495Arg Uncertain significance Single submitter
- HUNK p.Lys75Arg Uncertain significance Single submitter
- HUNK p.Lys96Arg Uncertain significance Single submitter
- HUNK p.Met558Ile Uncertain significance Single submitter
- HUNK p.Pro28Ser Uncertain significance Single submitter
- HUNK p.Pro345Leu Uncertain significance Single submitter
- HUNK p.Pro414Ser Uncertain significance Single submitter
- HUNK p.Pro525Ala Uncertain significance Single submitter
- HUNK p.Pro537Arg Uncertain significance Single submitter
- HUNK p.Pro553Leu Uncertain significance Single submitter
- HUNK p.Pro601Leu Uncertain significance Single submitter
- HUNK p.Pro641Leu Uncertain significance Single submitter
- HUNK p.Ser295Ile Uncertain significance Single submitter
- HUNK p.Ser468Leu Uncertain significance Single submitter
- HUNK p.Ser515Ala Uncertain significance Single submitter
- HUNK p.Ser595Gly Uncertain significance Single submitter
- HUNK p.Ser653Gly Uncertain significance Single submitter
- HUNK p.Thr260Met Uncertain significance Single submitter
- HUNK p.Thr287Ile Uncertain significance Single submitter
- HUNK p.Thr426Ile Uncertain significance Single submitter
- HUNK p.Tyr166Cys Uncertain significance Single submitter
- HUNK p.Tyr418Cys Uncertain significance Single submitter
- HUNK p.Val328Ala Uncertain significance Single submitter
- HUNK p.Val434Met Uncertain significance Single submitter
- HUNK p.Val587Leu Uncertain significance Single submitter
- HUNK p.Val710Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- HUNK p.Ala4Val Uncertain significance Single submitter
- HUNK p.Arg46Gly Uncertain significance Single submitter
- HUNK p.Arg662Trp Uncertain significance Single submitter
- HUNK p.Arg66Gly Uncertain significance Single submitter
- HUNK p.Arg675Leu Uncertain significance Single submitter
- HUNK p.Asn369His Uncertain significance Single submitter
- HUNK p.Gly11Arg Uncertain significance Single submitter
- HUNK p.Gly181Arg Uncertain significance Single submitter
- HUNK p.Gly669Arg Uncertain significance Single submitter
- HUNK p.Met665Thr Uncertain significance Single submitter
- HUNK p.Pro242Arg Uncertain significance Single submitter
- HUNK p.Pro38Leu Uncertain significance Single submitter
- HUNK p.Trp40Arg Uncertain significance Single submitter
- HUNK p.Tyr136Cys Uncertain significance Single submitter
All HUNK variants
Likely benign 5
- p.Arg404Gln Single submitter
- p.Arg427Gln Single submitter
- p.His570Gln Single submitter
- p.Met472Ile Single submitter
- p.Val513= Single submitter
Uncertain significance 93
- p.Ala272Ser Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Ala590Asp Single submitter ⚠
- p.Ala698Gly Single submitter ⚠
- p.Arg119His Single submitter ⚠
- p.Arg157Trp Single submitter
- p.Arg164His Single submitter ⚠
- p.Arg179Trp Single submitter
- p.Arg298His Single submitter ⚠
- p.Arg318Cys Single submitter ⚠
- p.Arg427Gly Single submitter ⚠
- p.Arg451Gln Single submitter ⚠
- p.Arg46Gly Single submitter ⚠
- p.Arg485Gln Single submitter ⚠
- p.Arg485Trp Single submitter ⚠
- p.Arg501His Single submitter ⚠
- p.Arg567His Single submitter ⚠
- p.Arg662Trp Single submitter ⚠
- p.Arg66Gly Single submitter ⚠
- p.Arg675Cys Single submitter ⚠
- p.Arg675Leu Single submitter ⚠
- p.Asn321Ile Single submitter ⚠
- p.Asn336Ser Single submitter ⚠
- p.Asn369His Single submitter ⚠
- p.Asn511Ser Single submitter ⚠
- p.Asn584Ile Single submitter ⚠
- p.Asn655Ser Single submitter ⚠
- p.Asn655Thr Single submitter ⚠
- p.Asp186Asn Single submitter ⚠
- p.Asp24His Single submitter ⚠
- p.Asp509Tyr Single submitter ⚠
- p.Asp708Asn Single submitter ⚠
- p.Cys32fs Single submitter
- p.Cys330Arg Single submitter ⚠
- p.Cys372Tyr Single submitter ⚠
- p.Cys637Tyr Single submitter ⚠
- p.Gln169Ter Single submitter
- p.Gln53Pro Single submitter ⚠
- p.Glu159Gln Single submitter ⚠
- p.Glu159Lys Single submitter ⚠
- p.Glu353Lys Single submitter ⚠
- p.Glu47Ter Single submitter
- p.Glu572Gly Single submitter ⚠
- p.Glu625Lys Single submitter ⚠
- p.Gly11Arg Single submitter ⚠
- p.Gly181Arg Single submitter ⚠
- p.Gly543Arg Single submitter ⚠
- p.Gly669Arg Single submitter ⚠
- p.His150Tyr Single submitter ⚠
- p.His184Leu Single submitter ⚠
- p.Ile189Thr Single submitter ⚠
- p.Ile521Val Single submitter ⚠
- p.Leu301Pro Single submitter ⚠
- p.Leu389Trp Single submitter ⚠
- p.Leu429Val Single submitter ⚠
- p.Leu702Val Single submitter ⚠
- p.Leu9Ile Single submitter ⚠
- p.Lys415Arg Single submitter ⚠
- p.Lys455Glu Single submitter ⚠
- p.Lys465Asn Single submitter ⚠
- p.Lys495Arg Single submitter ⚠
- p.Lys75Arg Single submitter ⚠
- p.Lys96Arg Single submitter ⚠
- p.Met558Ile Single submitter ⚠
- p.Met665Thr Single submitter ⚠
- p.Phe562Val Single submitter
- p.Pro219Leu Single submitter
- p.Pro242Arg Single submitter ⚠
- p.Pro28Ser Single submitter ⚠
- p.Pro345Leu Single submitter ⚠
- p.Pro38Leu Single submitter ⚠
- p.Pro414Ser Single submitter ⚠
- p.Pro525Ala Single submitter ⚠
- p.Pro537Arg Single submitter ⚠
- p.Pro553Leu Single submitter ⚠
- p.Pro601Leu Single submitter ⚠
- p.Pro641Leu Single submitter ⚠
- p.Ser295Ile Single submitter ⚠
- p.Ser468Leu Single submitter ⚠
- p.Ser515Ala Single submitter ⚠
- p.Ser595Gly Single submitter ⚠
- p.Ser653Gly Single submitter ⚠
- p.Thr260Met Single submitter ⚠
- p.Thr287Ile Single submitter ⚠
- p.Thr426Ile Single submitter ⚠
- p.Trp40Arg Single submitter ⚠
- p.Tyr136Cys Single submitter ⚠
- p.Tyr166Cys Single submitter ⚠
- p.Tyr418Cys Single submitter ⚠
- p.Val328Ala Single submitter ⚠
- p.Val434Met Single submitter ⚠
- p.Val587Leu Single submitter ⚠
- p.Val710Ile Single submitter ⚠