IL10 — 130 ClinVar variants
All ClinVar germline IL10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Conflicting · 6 Benign · 3 Benign/Likely benign · 63 Likely benign · 56 Uncertain significance
Full IL10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
IL10 p.Arg177Gln
Conflicting
Single submitter
inflammatory bowel disease
-
IL10 p.Gly15Arg
Conflicting
Single submitter
inflammatory bowel disease
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
IL10 p.Arg124Trp
Uncertain significance
Multiple submitters
inflammatory bowel disease
-
IL10 p.Leu13Met
Uncertain significance
Multiple submitters
inflammatory bowel disease
-
IL10 p.Ala107Glu
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Ala107Val
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Ala145Val
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Arg122Lys
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Arg124Gln
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Arg125His
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Arg125Leu
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Arg128Gln
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Asn115Tyr
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Asn178Lys
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Asp46Gly
Uncertain significance
Single submitter
inflammatory bowel disease
- IL10 p.Asp62Ala Uncertain significance Single submitter
-
IL10 p.Gln101Lys
Uncertain significance
Single submitter
inflammatory bowel disease
- IL10 p.Glu72Gly Uncertain significance Single submitter
-
IL10 p.Glu92Lys
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Gly21Asp
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.His108Arg
Uncertain significance
Single submitter
inflammatory bowel disease
- IL10 p.His2Arg Uncertain significance Single submitter
-
IL10 p.Ile105Ser
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Ile154Val
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Ile168Val
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Leu116Gln
Uncertain significance
Single submitter
inflammatory bowel disease
- IL10 p.Leu12Val Uncertain significance Single submitter
- IL10 p.Leu71Met Uncertain significance Single submitter
-
IL10 p.Lys106Gln
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Lys148Arg
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Lys148Met
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Met172Val
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Met174Thr
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Met40Val
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Met86Lys
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Phe129Tyr
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Pro38Ala
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Ser111Phe
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Ser49Asn
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Thr24Ser
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Thr31Ile
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Val142Leu
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Val16Leu
Uncertain significance
Single submitter
inflammatory bowel disease
Predictors split 8
The independent predictors disagree with each other — read with care.
-
IL10 p.Glu169Asp
Uncertain significance
Multiple submitters
inflammatory bowel disease
-
IL10 p.Pro34Thr
Uncertain significance
Multiple submitters
inflammatory bowel disease
-
IL10 p.Arg128Leu
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Ile168Lys
Uncertain significance
Single submitter
inflammatory bowel disease
-
IL10 p.Leu41Phe
Uncertain significance
Single submitter
inflammatory bowel disease
- IL10 p.Leu83Phe Uncertain significance Single submitter
- IL10 p.Lys52Met Uncertain significance Single submitter
- IL10 p.Phe164Ser Uncertain significance Single submitter
All IL10 variants
Conflicting classifications of pathogenicity 2
- p.Arg177Gln Single submitter inflammatory bowel disease ⚠
- p.Gly15Arg Single submitter inflammatory bowel disease ⚠
Benign 6
- c.225+56A>G Multiple submitters inflammatory bowel disease
- c.378+284G>T Multiple submitters inflammatory bowel disease
- c.166-101T>G Single submitter
- c.379-10del Single submitter inflammatory bowel disease
- c.379-112A>G Single submitter
- c.*117T>C Single submitter
Benign/Likely benign 3
- c.165+8T>C Multiple submitters inflammatory bowel disease
- c.166-15T>C Multiple submitters inflammatory bowel disease
- c.378+19T>C Multiple submitters inflammatory bowel disease
Likely benign 63
- c.165+20G>A Multiple submitters inflammatory bowel disease
- p.Ala107= Multiple submitters inflammatory bowel disease
- p.Ala145= Multiple submitters inflammatory bowel disease
- p.Asn115= Multiple submitters inflammatory bowel disease
- p.Glu85= Multiple submitters inflammatory bowel disease
- p.His2= Multiple submitters inflammatory bowel disease
- p.Leu112= Multiple submitters inflammatory bowel disease
- c.165+10A>T Single submitter inflammatory bowel disease
- c.165+14C>T Single submitter inflammatory bowel disease
- c.165+15T>C Single submitter inflammatory bowel disease
- c.166-19C>T Single submitter inflammatory bowel disease
- c.166-5T>G Single submitter inflammatory bowel disease
- c.166-7C>T Single submitter inflammatory bowel disease
- c.225+15G>A Single submitter inflammatory bowel disease
- c.225+17G>A Single submitter inflammatory bowel disease
- c.225+18G>A Single submitter inflammatory bowel disease
- c.225+20G>A Single submitter inflammatory bowel disease
- c.225+7G>A Single submitter inflammatory bowel disease
- c.378+15A>C Single submitter inflammatory bowel disease
- c.378+16G>C Single submitter inflammatory bowel disease
- c.378+19_378+20delinsCC Single submitter inflammatory bowel disease
- c.379-14C>G Single submitter inflammatory bowel disease
- c.379-16C>T Single submitter inflammatory bowel disease
- c.379-17T>C Single submitter inflammatory bowel disease
- c.379-19T>G Single submitter inflammatory bowel disease
- c.444+17G>A Single submitter inflammatory bowel disease
- c.444+20G>A Single submitter inflammatory bowel disease
- c.444+8T>C Single submitter inflammatory bowel disease
- c.445-7del Single submitter inflammatory bowel disease
- c.445-7T>G Single submitter inflammatory bowel disease
- c.445-8C>T Single submitter inflammatory bowel disease
- c.*15G>C Single submitter
- p.Ala138= Single submitter inflammatory bowel disease
- p.Ala157= Single submitter inflammatory bowel disease
- p.Ala170= Single submitter inflammatory bowel disease
- p.Arg124= Single submitter inflammatory bowel disease
- p.Arg125= Single submitter inflammatory bowel disease
- p.Arg45= Single submitter inflammatory bowel disease
- p.Asn28= Single submitter inflammatory bowel disease
- p.Asp43= Single submitter inflammatory bowel disease
- p.Cys9= Single submitter inflammatory bowel disease
- p.Gln22= Single submitter inflammatory bowel disease
- p.Glu92= Single submitter inflammatory bowel disease
- p.Glu99= Single submitter inflammatory bowel disease
- p.Gly23= Single submitter inflammatory bowel disease
- p.Gly76= Single submitter inflammatory bowel disease
- p.Gly79= Single submitter inflammatory bowel disease
- p.Ile87= Single submitter inflammatory bowel disease
- p.Leu10= Single submitter inflammatory bowel disease
- p.Leu121= Single submitter inflammatory bowel disease
- p.Leu6= Single submitter inflammatory bowel disease
- p.Leu65= Single submitter inflammatory bowel disease
- p.Leu71= Single submitter inflammatory bowel disease
- p.Leu91= Single submitter inflammatory bowel disease
- p.Lys67= Single submitter inflammatory bowel disease
- p.Phe146= Single submitter inflammatory bowel disease
- p.Phe164= Single submitter inflammatory bowel disease
- p.Pro103= Single submitter inflammatory bowel disease
- p.Pro131= Single submitter inflammatory bowel disease
- p.Ser19Asn Single submitter inflammatory bowel disease
- p.Ser4= Single submitter inflammatory bowel disease
- p.Ser84= Single submitter inflammatory bowel disease
- p.Tyr171= Single submitter inflammatory bowel disease
Uncertain significance 56
- c.225+6A>G Multiple submitters inflammatory bowel disease
- p.Arg124Trp Multiple submitters inflammatory bowel disease ⚠
- p.Arg177Ter Multiple submitters inflammatory bowel disease
- p.Glu169Asp Multiple submitters inflammatory bowel disease ⚠
- p.Leu13Met Multiple submitters inflammatory bowel disease ⚠
- p.Pro34Thr Multiple submitters inflammatory bowel disease ⚠
- c.378+6T>C Single submitter inflammatory bowel disease
- c.444+6C>T Single submitter inflammatory bowel disease
- p.Ala107Glu Single submitter inflammatory bowel disease ⚠
- p.Ala107Val Single submitter inflammatory bowel disease ⚠
- p.Ala145Val Single submitter inflammatory bowel disease ⚠
- p.Arg122Lys Single submitter inflammatory bowel disease ⚠
- p.Arg124Gln Single submitter inflammatory bowel disease ⚠
- p.Arg125His Single submitter inflammatory bowel disease ⚠
- p.Arg125Leu Single submitter inflammatory bowel disease ⚠
- p.Arg128Gln Single submitter inflammatory bowel disease ⚠
- p.Arg128Leu Single submitter inflammatory bowel disease ⚠
- p.Arg45Gln Single submitter inflammatory bowel disease
- p.Asn115Tyr Single submitter inflammatory bowel disease ⚠
- p.Asn178Lys Single submitter inflammatory bowel disease ⚠
- p.Asp46Gly Single submitter inflammatory bowel disease ⚠
- p.Asp62Ala Single submitter ⚠
- p.Gln101Lys Single submitter inflammatory bowel disease ⚠
- p.Gln81Lys Single submitter inflammatory bowel disease
- p.Glu72Gly Single submitter ⚠
- p.Glu92Lys Single submitter inflammatory bowel disease ⚠
- p.Gly21Asp Single submitter inflammatory bowel disease ⚠
- p.His108Arg Single submitter inflammatory bowel disease ⚠
- p.His2Arg Single submitter ⚠
- p.Ile105Ser Single submitter inflammatory bowel disease ⚠
- p.Ile154Val Single submitter inflammatory bowel disease ⚠
- p.Ile168Lys Single submitter inflammatory bowel disease ⚠
- p.Ile168Val Single submitter inflammatory bowel disease ⚠
- p.Leu116Gln Single submitter inflammatory bowel disease ⚠
- p.Leu12Val Single submitter ⚠
- p.Leu41Phe Single submitter inflammatory bowel disease ⚠
- p.Leu70Ter Single submitter inflammatory bowel disease
- p.Leu71Met Single submitter ⚠
- p.Leu83Phe Single submitter ⚠
- p.Lys106Gln Single submitter inflammatory bowel disease ⚠
- p.Lys148Arg Single submitter inflammatory bowel disease ⚠
- p.Lys148Met Single submitter inflammatory bowel disease ⚠
- p.Lys52Met Single submitter ⚠
- p.Met172Val Single submitter inflammatory bowel disease ⚠
- p.Met174Thr Single submitter inflammatory bowel disease ⚠
- p.Met40Val Single submitter inflammatory bowel disease ⚠
- p.Met86Lys Single submitter inflammatory bowel disease ⚠
- p.Phe129Tyr Single submitter inflammatory bowel disease ⚠
- p.Phe164Ser Single submitter ⚠
- p.Pro38Ala Single submitter inflammatory bowel disease ⚠
- p.Ser111Phe Single submitter inflammatory bowel disease ⚠
- p.Ser49Asn Single submitter inflammatory bowel disease ⚠
- p.Thr24Ser Single submitter inflammatory bowel disease ⚠
- p.Thr31Ile Single submitter inflammatory bowel disease ⚠
- p.Val142Leu Single submitter inflammatory bowel disease ⚠
- p.Val16Leu Single submitter inflammatory bowel disease ⚠