IL5 — 15 ClinVar variants
All ClinVar germline IL5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
3 Benign · 2 Likely benign · 10 Uncertain significance
Full IL5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IL5 p.Ala28Thr Uncertain significance Single submitter
- IL5 p.Asn127Ile Uncertain significance Single submitter
- IL5 p.Gly81Ala Uncertain significance Single submitter
- IL5 p.Ile131Val Uncertain significance Single submitter
- IL5 p.Lys104Asn Uncertain significance Single submitter
- IL5 p.Thr49Ile Uncertain significance Single submitter
- IL5 p.Thr49Ser Uncertain significance Single submitter
- IL5 p.Val30Met Uncertain significance Single submitter
- IL5 p.Val54Leu Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All IL5 variants
Likely benign 2
- p.Ile132Met Single submitter
- p.Val17Met Single submitter
Uncertain significance 10
- p.Ala28Thr Single submitter ⚠
- p.Asn127Ile Single submitter ⚠
- p.Asn90Lys Single submitter ⚠
- p.Gly81Ala Single submitter ⚠
- p.Ile131Val Single submitter ⚠
- p.Lys104Asn Single submitter ⚠
- p.Thr49Ile Single submitter ⚠
- p.Thr49Ser Single submitter ⚠
- p.Val30Met Single submitter ⚠
- p.Val54Leu Single submitter ⚠