ILF3 — 100 ClinVar variants

All ClinVar germline ILF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →

1 Benign · 8 Likely benign · 91 Uncertain significance

Full ILF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 86

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 62

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 24

The independent predictors disagree with each other — read with care.

All ILF3 variants

Benign 1

p.Arg655= Multiple submitters

Likely benign 8

c.1070-15G>A Single submitter
p.Ala496Pro Single submitter
p.Asn764Ser Single submitter
p.Asn795Ser Single submitter
p.Gly821Ser Single submitter
p.Ser651Asn Single submitter
p.Ser704Gly Single submitter
p.Thr24= Single submitter

Uncertain significance 91

p.Ala123Thr Single submitter ⚠
p.Ala268Val Single submitter ⚠
p.Ala397Ser Single submitter ⚠
p.Ala488Thr Single submitter ⚠
p.Ala494Val Single submitter ⚠
p.Ala507Val Single submitter ⚠
p.Ala515Val Single submitter ⚠
p.Ala573Thr Single submitter ⚠
p.Ala599Ser Single submitter ⚠
p.Ala602Gly Single submitter ⚠
p.Ala686Val Single submitter ⚠
p.Ala735Thr Single submitter ⚠
p.Arg12Cys Single submitter ⚠
p.Arg2His Single submitter ⚠
p.Arg408Trp Single submitter ⚠
p.Arg558Cys Single submitter
p.Arg87Thr Single submitter ⚠
p.Asn192Thr Single submitter ⚠
p.Asn624Ile Single submitter ⚠
p.Asn665Thr Single submitter ⚠
p.Asn812Ser Single submitter ⚠
p.Asn863Asp Single submitter ⚠
p.Asn894Tyr Single submitter ⚠
p.Asp109Glu Single submitter ⚠
p.Asp152Asn Single submitter ⚠
p.Asp337Glu Single submitter ⚠
p.Asp804Ala Single submitter ⚠
p.Gln148Pro Single submitter ⚠
p.Gln329His Single submitter ⚠
p.Gln463Glu Single submitter ⚠
p.Gln744Arg Single submitter ⚠
p.Gln775Glu Single submitter ⚠
p.Gln775Leu Single submitter ⚠
p.Gln879Glu Single submitter ⚠
p.Glu111Asp Single submitter ⚠
p.Glu75Gly Single submitter ⚠
p.Gly244Arg Single submitter ⚠
p.Gly248Asp Single submitter ⚠
p.Gly378Arg Single submitter ⚠
p.Gly631Ser Single submitter ⚠
p.Gly660Glu Single submitter ⚠
p.Gly682Arg Single submitter ⚠
p.Gly689Asp Single submitter ⚠
p.Gly709Arg Single submitter ⚠
p.Gly716Ser Single submitter ⚠
p.Gly800Arg Single submitter ⚠
p.Gly842Arg Single submitter ⚠
p.Gly846Asp Single submitter ⚠
p.Gly847Ser Single submitter ⚠
p.Ile134Val Single submitter ⚠
p.Ile431Met Single submitter
p.Leu246Phe Single submitter ⚠
p.Leu586Phe Single submitter ⚠
p.Lys119Met Single submitter ⚠
p.Lys143Glu Single submitter ⚠
p.Met15Thr Single submitter ⚠
p.Met180Thr Single submitter ⚠
p.Pro194Ser Single submitter ⚠
p.Pro338Ser Single submitter ⚠
p.Pro468Ala Single submitter ⚠
p.Pro641His Single submitter ⚠
p.Pro69Ala Single submitter ⚠
p.Pro729Leu Single submitter ⚠
p.Pro731Leu Single submitter ⚠
p.Pro797Ala Single submitter ⚠
p.Ser19Phe Single submitter ⚠
p.Ser476Leu Single submitter ⚠
p.Ser477Asn Single submitter ⚠
p.Ser554Asn Single submitter ⚠
p.Ser751Leu Single submitter ⚠
p.Ser791Leu Single submitter ⚠
p.Ser848Ala Single submitter ⚠
p.Ser877Pro Single submitter ⚠
p.Ser892Ile Single submitter ⚠
p.Thr140Ala Single submitter ⚠
p.Thr188Met Single submitter ⚠
p.Thr261Met Single submitter ⚠
p.Thr368Met Single submitter ⚠
p.Thr469Met Single submitter ⚠
p.Thr82Met Single submitter ⚠
p.Tyr871Cys Single submitter ⚠
p.Val150fs Single submitter
p.Val227Asp Single submitter ⚠
p.Val240Leu Single submitter ⚠
p.Val459Ile Single submitter ⚠
p.Val493Leu Single submitter ⚠
p.Val502Ile Single submitter ⚠
p.Val518Ala Single submitter
p.Val518Ile Single submitter
p.Val560Ile Single submitter ⚠
p.Val612Ile Single submitter ⚠