INHA — 59 ClinVar variants
All ClinVar germline INHA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
3 Benign · 2 Benign/Likely benign · 9 Likely benign · 45 Uncertain significance
Full INHA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- INHA p.Ala144Val Uncertain significance Single submitter
- INHA p.Ala207Thr Uncertain significance Single submitter
- INHA p.Ala45Thr Uncertain significance Single submitter
- INHA p.Ala63Val Uncertain significance Single submitter
- INHA p.Arg247His Uncertain significance Single submitter
- INHA p.Arg247Ser Uncertain significance Single submitter
- INHA p.Arg26Gln Uncertain significance Single submitter
- INHA p.Arg70Gly Uncertain significance Single submitter
- INHA p.Cys262Tyr Uncertain significance Single submitter
- INHA p.Gly227Glu Uncertain significance Single submitter
- INHA p.His191Gln Uncertain significance Single submitter
- INHA p.Ile84Val Uncertain significance Single submitter
- INHA p.Leu202Ile Uncertain significance Single submitter
- INHA p.Leu236Val Uncertain significance Single submitter
- INHA p.Pro174Ser Uncertain significance Single submitter
- INHA p.Pro213Leu Uncertain significance Single submitter
- INHA p.Pro235Thr Uncertain significance Single submitter
- INHA p.Pro243Arg Uncertain significance Single submitter
- INHA p.Pro253Leu Uncertain significance Single submitter
- INHA p.Pro256Leu Uncertain significance Single submitter
- INHA p.Pro59Arg Uncertain significance Single submitter
- INHA p.Ser349Phe Uncertain significance Single submitter
- INHA p.Tyr290Cys Uncertain significance Single submitter
- INHA p.Val33Met Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- INHA p.Arg116Trp Uncertain significance Single submitter
- INHA p.Arg122Cys Uncertain significance Single submitter
- INHA p.Arg122His Uncertain significance Single submitter
- INHA p.Arg26Trp Uncertain significance Single submitter
- INHA p.Arg341Cys Uncertain significance Single submitter
- INHA p.Arg341His Uncertain significance Single submitter
- INHA p.Arg56Met Uncertain significance Single submitter
- INHA p.Arg56Trp Uncertain significance Single submitter
- INHA p.Arg60Gln Uncertain significance Single submitter
- INHA p.Glu75Lys Uncertain significance Single submitter
- INHA p.Gly136Arg Uncertain significance Single submitter
- INHA p.His171Tyr Uncertain significance Single submitter
- INHA p.Ile84Met Uncertain significance Single submitter
- INHA p.Met335Thr Uncertain significance Single submitter
- INHA p.Pro159Leu Uncertain significance Single submitter
- INHA p.Pro223Gln Uncertain significance Single submitter
- INHA p.Ser128Leu Uncertain significance Single submitter
- INHA p.Ser148Ala Uncertain significance Single submitter
- INHA p.Ser304Phe Uncertain significance Single submitter
- INHA p.Val178Met Uncertain significance Single submitter
All INHA variants
Benign 3
Benign/Likely benign 2
- p.Ala257Thr Multiple submitters primary ovarian failure
- p.Gly65= Multiple submitters
Likely benign 9
- p.Pro166= Multiple submitters
- p.Ala25Asp Single submitter
- p.Ala315Val Single submitter
- p.Arg199His Single submitter
- p.Gly160Ala Single submitter
- p.Met114Val Single submitter
- p.Ser187Pro Single submitter
- p.His69= No assertion criteria INHA-related disorder
- p.Leu249= No assertion criteria INHA-related disorder
Uncertain significance 45
- p.Ala144Val Single submitter ⚠
- p.Ala207Thr Single submitter ⚠
- p.Ala45Thr Single submitter ⚠
- p.Ala63Val Single submitter ⚠
- p.Arg116Trp Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg247His Single submitter ⚠
- p.Arg247Ser Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg26Trp Single submitter ⚠
- p.Arg341Cys Single submitter ⚠
- p.Arg341His Single submitter ⚠
- p.Arg56Met Single submitter ⚠
- p.Arg56Trp Single submitter ⚠
- p.Arg60Gln Single submitter ⚠
- p.Arg70Gly Single submitter ⚠
- p.Cys262Tyr Single submitter ⚠
- p.Glu75Lys Single submitter ⚠
- p.Gly136Arg Single submitter ⚠
- p.Gly227Glu Single submitter ⚠
- p.His171Tyr Single submitter ⚠
- p.His191Gln Single submitter ⚠
- p.Ile84Met Single submitter ⚠
- p.Ile84Val Single submitter ⚠
- p.Leu202Ile Single submitter ⚠
- p.Leu236Val Single submitter ⚠
- p.Met335Thr Single submitter ⚠
- p.Pro159Leu Single submitter ⚠
- p.Pro174Ser Single submitter ⚠
- p.Pro213Leu Single submitter ⚠
- p.Pro223Gln Single submitter ⚠
- p.Pro235Thr Single submitter ⚠
- p.Pro243Arg Single submitter ⚠
- p.Pro253Leu Single submitter ⚠
- p.Pro256Leu Single submitter ⚠
- p.Pro59Arg Single submitter ⚠
- p.Ser128Leu Single submitter ⚠
- p.Ser148Ala Single submitter ⚠
- p.Ser304Phe Single submitter ⚠
- p.Ser349Phe Single submitter ⚠
- p.Tyr290Cys Single submitter ⚠
- p.Val178Met Single submitter ⚠
- p.Val33Met Single submitter ⚠
- c.-16C>T No assertion criteria