INMT — 58 ClinVar variants
All ClinVar germline INMT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
7 Benign · 5 Likely benign · 46 Uncertain significance
Full INMT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- INMT p.Ala134Glu Uncertain significance Single submitter
- INMT p.Ala215Thr Uncertain significance Single submitter
- INMT p.Ala247Ser Uncertain significance Single submitter
- INMT p.Ala247Val Uncertain significance Single submitter
- INMT p.Arg18Thr Uncertain significance Single submitter
-
INMT p.Arg209Cys
Uncertain significance
Single submitter
prostate cancer
- INMT p.Arg89Cys Uncertain significance Single submitter
- INMT p.Gln240His Uncertain significance Single submitter
- INMT p.Glu219Asp Uncertain significance Single submitter
- INMT p.Glu36Lys Uncertain significance Single submitter
- INMT p.Glu43Lys Uncertain significance Single submitter
- INMT p.Glu92Lys Uncertain significance Single submitter
- INMT p.Gly191Asp Uncertain significance Single submitter
- INMT p.Gly3Ser Uncertain significance Single submitter
- INMT p.Leu117Pro Uncertain significance Single submitter
- INMT p.Leu164Pro Uncertain significance Single submitter
- INMT p.Leu235Phe Uncertain significance Single submitter
- INMT p.Lys208Asn Uncertain significance Single submitter
- INMT p.Met205Ile Uncertain significance Single submitter
- INMT p.Pro102Thr Uncertain significance Single submitter
- INMT p.Pro202Leu Uncertain significance Single submitter
- INMT p.Pro263Thr Uncertain significance Single submitter
- INMT p.Pro33His Uncertain significance Single submitter
- INMT p.Pro66Leu Uncertain significance Single submitter
- INMT p.Ser121Arg Uncertain significance Single submitter
- INMT p.Ser77Phe Uncertain significance Single submitter
- INMT p.Thr198Met Uncertain significance Single submitter
- INMT p.Thr48Ile Uncertain significance Single submitter
- INMT p.Trp97Cys Uncertain significance Single submitter
- INMT p.Tyr105His Uncertain significance Single submitter
- INMT p.Val221Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- INMT p.Ala104Thr Uncertain significance Single submitter
- INMT p.Arg137Trp Uncertain significance Single submitter
- INMT p.Arg177His Uncertain significance Single submitter
- INMT p.Arg200Trp Uncertain significance Single submitter
- INMT p.Arg258Gly Uncertain significance Single submitter
- INMT p.Arg258Leu Uncertain significance Single submitter
- INMT p.Asp88Asn Uncertain significance Single submitter
- INMT p.Cys141Arg Uncertain significance Single submitter
- INMT p.Cys168Arg Uncertain significance Single submitter
- INMT p.Gly207Arg Uncertain significance Single submitter
- INMT p.Gly251Glu Uncertain significance Single submitter
- INMT p.Pro151Leu Uncertain significance Single submitter
- INMT p.Trp124Arg Uncertain significance Single submitter
- INMT p.Tyr105Cys Uncertain significance Single submitter
- INMT p.Tyr176Asn Uncertain significance Single submitter
All INMT variants
Benign 7
- p.Ala114Thr Single submitter
- p.Arg123Ter Single submitter
- p.Leu145= Single submitter
- p.Phe113= Single submitter
- p.Pro189= Single submitter
- p.Ser84= Single submitter
- p.Ter264Ser Single submitter
Likely benign 5
- c.363-7T>A Multiple submitters
- p.Ala134Thr Single submitter
- p.Asn249Ser Single submitter
- p.Gln240Arg Single submitter
- p.Ser121= Single submitter
Uncertain significance 46
- p.Ala104Thr Single submitter ⚠
- p.Ala134Glu Single submitter ⚠
- p.Ala215Thr Single submitter ⚠
- p.Ala247Ser Single submitter ⚠
- p.Ala247Val Single submitter ⚠
- p.Arg137Trp Single submitter ⚠
- p.Arg177His Single submitter ⚠
- p.Arg18Thr Single submitter ⚠
- p.Arg200Trp Single submitter ⚠
- p.Arg209Cys Single submitter prostate cancer ⚠
- p.Arg258Gly Single submitter ⚠
- p.Arg258Leu Single submitter ⚠
- p.Arg89Cys Single submitter ⚠
- p.Asp88Asn Single submitter ⚠
- p.Cys141Arg Single submitter ⚠
- p.Cys168Arg Single submitter ⚠
- p.Gln240His Single submitter ⚠
- p.Glu219Asp Single submitter ⚠
- p.Glu36Lys Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.Glu92Lys Single submitter ⚠
- p.Gly191Asp Single submitter ⚠
- p.Gly207Arg Single submitter ⚠
- p.Gly251Glu Single submitter ⚠
- p.Gly3Ser Single submitter ⚠
- p.Leu117Pro Single submitter ⚠
- p.Leu164Pro Single submitter ⚠
- p.Leu235Phe Single submitter ⚠
- p.Lys208Asn Single submitter ⚠
- p.Met205Ile Single submitter ⚠
- p.Pro102Thr Single submitter ⚠
- p.Pro151Leu Single submitter ⚠
- p.Pro202Leu Single submitter ⚠
- p.Pro263Thr Single submitter ⚠
- p.Pro33His Single submitter ⚠
- p.Pro66Leu Single submitter ⚠
- p.Ser121Arg Single submitter ⚠
- p.Ser77Phe Single submitter ⚠
- p.Thr198Met Single submitter ⚠
- p.Thr48Ile Single submitter ⚠
- p.Trp124Arg Single submitter ⚠
- p.Trp97Cys Single submitter ⚠
- p.Tyr105Cys Single submitter ⚠
- p.Tyr105His Single submitter ⚠
- p.Tyr176Asn Single submitter ⚠
- p.Val221Met Single submitter ⚠