INO80C — 43 ClinVar variants
All ClinVar germline INO80C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
2 Benign · 3 Likely benign · 38 Uncertain significance
Full INO80C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- INO80C p.Ala117Val Uncertain significance Single submitter
- INO80C p.Ala47Val Uncertain significance Single submitter
- INO80C p.Ala51Ser Uncertain significance Single submitter
- INO80C p.Ala96Thr Uncertain significance Single submitter
- INO80C p.Arg160Trp Uncertain significance Single submitter
- INO80C p.Asn30Ser Uncertain significance Single submitter
- INO80C p.Gly53Asp Uncertain significance Single submitter
- INO80C p.Gly53Ser Uncertain significance Single submitter
- INO80C p.Ile170Phe Uncertain significance Single submitter
- INO80C p.Ile190Val Uncertain significance Single submitter
- INO80C p.Ile5Phe Uncertain significance Single submitter
- INO80C p.Ile7Leu Uncertain significance Single submitter
- INO80C p.Ile7Thr Uncertain significance Single submitter
- INO80C p.Pro133Leu Uncertain significance Single submitter
- INO80C p.Pro14Leu Uncertain significance Single submitter
- INO80C p.Pro24Leu Uncertain significance Single submitter
- INO80C p.Pro73Ser Uncertain significance Single submitter
- INO80C p.Ser20Asn Uncertain significance Single submitter
- INO80C p.Ser40Thr Uncertain significance Single submitter
- INO80C p.Ser46Ala Uncertain significance Single submitter
- INO80C p.Ser48Ala Uncertain significance Single submitter
- INO80C p.Ser48Pro Uncertain significance Single submitter
- INO80C p.Ser48Tyr Uncertain significance Single submitter
- INO80C p.Ser49Asn Uncertain significance Single submitter
- INO80C p.Ser60Gly Uncertain significance Single submitter
- INO80C p.Tyr169Cys Uncertain significance Single submitter
- INO80C p.Tyr37Cys Uncertain significance Single submitter
- INO80C p.Tyr37His Uncertain significance Single submitter
- INO80C p.Tyr37Phe Uncertain significance Single submitter
- INO80C p.Tyr37Ser Uncertain significance Single submitter
- INO80C p.Val178Ile Uncertain significance Single submitter
- INO80C p.Val65Leu Uncertain significance Single submitter
- INO80C p.Val8Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All INO80C variants
Benign 2
- c.380-6T>C Multiple submitters
- p.Thr179= Multiple submitters
Likely benign 3
- p.Gly38Ser Single submitter
- p.His93= Single submitter
- p.Ser49Gly Single submitter
Uncertain significance 38
- p.Ala113Thr Single submitter ⚠
- p.Ala117Val Single submitter ⚠
- p.Ala47Val Single submitter ⚠
- p.Ala51Ser Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Arg160Trp Single submitter ⚠
- p.Arg23Lys Single submitter ⚠
- p.Asn30Ser Single submitter ⚠
- p.Gly53Asp Single submitter ⚠
- p.Gly53Ser Single submitter ⚠
- p.Ile170Phe Single submitter ⚠
- p.Ile190Val Single submitter ⚠
- p.Ile5Phe Single submitter ⚠
- p.Ile7Leu Single submitter ⚠
- p.Ile7Thr Single submitter ⚠
- p.Pro133Leu Single submitter ⚠
- p.Pro14Leu Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Ser20Asn Single submitter ⚠
- p.Ser26Cys Single submitter ⚠
- p.Ser40Thr Single submitter ⚠
- p.Ser46Ala Single submitter ⚠
- p.Ser48Ala Single submitter ⚠
- p.Ser48Pro Single submitter ⚠
- p.Ser48Tyr Single submitter ⚠
- p.Ser49Asn Single submitter ⚠
- p.Ser60Gly Single submitter ⚠
- p.Tyr169Cys Single submitter ⚠
- p.Tyr37Cys Single submitter ⚠
- p.Tyr37His Single submitter ⚠
- p.Tyr37Phe Single submitter ⚠
- p.Tyr37Ser Single submitter ⚠
- p.Val177Ala Single submitter ⚠
- p.Val178Ile Single submitter ⚠
- p.Val65Leu Single submitter ⚠
- p.Val89Gly Single submitter ⚠
- p.Val8Leu Single submitter ⚠