IPMK — 60 ClinVar variants
All ClinVar germline IPMK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
2 Benign · 6 Likely benign · 52 Uncertain significance
Full IPMK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- IPMK p.Ala228Val Uncertain significance Single submitter
- IPMK p.Ala319Val Uncertain significance Single submitter
- IPMK p.Arg10Gln Uncertain significance Single submitter
- IPMK p.Arg10Trp Uncertain significance Single submitter
- IPMK p.Arg320His Uncertain significance Single submitter
- IPMK p.Asn138Ile Uncertain significance Single submitter
- IPMK p.Asn344Lys Uncertain significance Single submitter
- IPMK p.Asn344Ser Uncertain significance Single submitter
- IPMK p.Asn44Tyr Uncertain significance Single submitter
- IPMK p.Asn91Lys Uncertain significance Single submitter
- IPMK p.Asp189Asn Uncertain significance Single submitter
- IPMK p.Asp285Tyr Uncertain significance Single submitter
- IPMK p.Asp97Glu Uncertain significance Single submitter
- IPMK p.Gln282His Uncertain significance Single submitter
- IPMK p.Glu275Gln Uncertain significance Single submitter
- IPMK p.Gly115Ser Uncertain significance Single submitter
- IPMK p.Gly199Arg Uncertain significance Single submitter
- IPMK p.Gly402Glu Uncertain significance Single submitter
- IPMK p.His329Arg Uncertain significance Single submitter
- IPMK p.His330Arg Uncertain significance Single submitter
- IPMK p.Ile174Leu Uncertain significance Single submitter
- IPMK p.Ile174Val Uncertain significance Single submitter
- IPMK p.Ile207Val Uncertain significance Single submitter
- IPMK p.Ile233Thr Uncertain significance Single submitter
- IPMK p.Ile413Val Uncertain significance Single submitter
- IPMK p.Leu273Ser Uncertain significance Single submitter
- IPMK p.Leu43Phe Uncertain significance Single submitter
- IPMK p.Leu9His Uncertain significance Single submitter
- IPMK p.Lys244Glu Uncertain significance Single submitter
- IPMK p.Lys280Asn Uncertain significance Single submitter
- IPMK p.Lys347Gln Uncertain significance Single submitter
- IPMK p.Lys60Glu Uncertain significance Single submitter
- IPMK p.Pro119Ser Uncertain significance Single submitter
- IPMK p.Pro16Leu Uncertain significance Single submitter
- IPMK p.Pro17Thr Uncertain significance Single submitter
- IPMK p.Ser22Leu Uncertain significance Single submitter
- IPMK p.Ser300Phe Uncertain significance Single submitter
- IPMK p.Ser360Tyr Uncertain significance Single submitter
- IPMK p.Thr301Ile Uncertain significance Single submitter
- IPMK p.Thr32Asn Uncertain significance Single submitter
- IPMK p.Thr371Ala Uncertain significance Single submitter
- IPMK p.Thr3Ala Uncertain significance Single submitter
- IPMK p.Tyr184His Uncertain significance Single submitter
- IPMK p.Tyr325Cys Uncertain significance Single submitter
- IPMK p.Val297Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- IPMK p.Ala250Thr Uncertain significance Single submitter
- IPMK p.Ile142Leu Uncertain significance Single submitter
- IPMK p.Met57Thr Uncertain significance Single submitter
- IPMK p.Pro48Ser Uncertain significance Single submitter
- IPMK p.Pro80Leu Uncertain significance Single submitter
- IPMK p.Val133Ala Uncertain significance Single submitter
- IPMK p.Val47Met Uncertain significance Single submitter
All IPMK variants
Likely benign 6
- p.Arg213Lys Single submitter
- p.Arg411Gln Single submitter
- p.Gly15= Single submitter
- p.Ile207Leu Single submitter
- p.Leu66= Single submitter
- p.Thr28Ala Single submitter
Uncertain significance 52
- p.Ala228Val Single submitter ⚠
- p.Ala250Thr Single submitter ⚠
- p.Ala319Val Single submitter ⚠
- p.Arg10Gln Single submitter ⚠
- p.Arg10Trp Single submitter ⚠
- p.Arg320His Single submitter ⚠
- p.Asn138Ile Single submitter ⚠
- p.Asn344Lys Single submitter ⚠
- p.Asn344Ser Single submitter ⚠
- p.Asn44Tyr Single submitter ⚠
- p.Asn91Lys Single submitter ⚠
- p.Asp189Asn Single submitter ⚠
- p.Asp285Tyr Single submitter ⚠
- p.Asp97Glu Single submitter ⚠
- p.Gln282His Single submitter ⚠
- p.Glu275Gln Single submitter ⚠
- p.Gly115Ser Single submitter ⚠
- p.Gly199Arg Single submitter ⚠
- p.Gly402Glu Single submitter ⚠
- p.His329Arg Single submitter ⚠
- p.His330Arg Single submitter ⚠
- p.Ile142Leu Single submitter ⚠
- p.Ile174Leu Single submitter ⚠
- p.Ile174Val Single submitter ⚠
- p.Ile207Val Single submitter ⚠
- p.Ile233Thr Single submitter ⚠
- p.Ile413Val Single submitter ⚠
- p.Leu273Ser Single submitter ⚠
- p.Leu43Phe Single submitter ⚠
- p.Leu9His Single submitter ⚠
- p.Lys244Glu Single submitter ⚠
- p.Lys280Asn Single submitter ⚠
- p.Lys347Gln Single submitter ⚠
- p.Lys60Glu Single submitter ⚠
- p.Met57Thr Single submitter ⚠
- p.Pro119Ser Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro17Thr Single submitter ⚠
- p.Pro48Ser Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser22Leu Single submitter ⚠
- p.Ser300Phe Single submitter ⚠
- p.Ser360Tyr Single submitter ⚠
- p.Thr301Ile Single submitter ⚠
- p.Thr32Asn Single submitter ⚠
- p.Thr371Ala Single submitter ⚠
- p.Thr3Ala Single submitter ⚠
- p.Tyr184His Single submitter ⚠
- p.Tyr325Cys Single submitter ⚠
- p.Val133Ala Single submitter ⚠
- p.Val297Leu Single submitter ⚠
- p.Val47Met Single submitter ⚠