KIF18B — 3 ClinVar variants
All ClinVar germline KIF18B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2 flagged for review →
1 Likely benign · 2 Uncertain significance
Full KIF18B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 2
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 1
The independent predictors disagree with each other — read with care.
All KIF18B variants
Likely benign 1
- p.Thr589= Single submitter
Uncertain significance 2
- p.Asn289Lys Single submitter ⚠
- p.Asp293Asn Single submitter ⚠