KLK13 — 58 ClinVar variants
All ClinVar germline KLK13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Likely benign · 56 Uncertain significance
Full KLK13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLK13 p.Ala179Thr Uncertain significance Single submitter
- KLK13 p.Ala90Ser Uncertain significance Single submitter
- KLK13 p.Ala90Val Uncertain significance Single submitter
- KLK13 p.Ala96Thr Uncertain significance Single submitter
- KLK13 p.Arg150His Uncertain significance Single submitter
- KLK13 p.Arg184Leu Uncertain significance Single submitter
- KLK13 p.Arg244Gln Uncertain significance Single submitter
- KLK13 p.Arg259His Uncertain significance Single submitter
- KLK13 p.Arg259Ser Uncertain significance Single submitter
- KLK13 p.Arg263Gln Uncertain significance Single submitter
- KLK13 p.Arg58Trp Uncertain significance Single submitter
- KLK13 p.Asn148Asp Uncertain significance Single submitter
- KLK13 p.Asn30Ser Uncertain significance Single submitter
- KLK13 p.Cys77Arg Uncertain significance Single submitter
- KLK13 p.Gln131Pro Uncertain significance Single submitter
- KLK13 p.Gln191Arg Uncertain significance Single submitter
- KLK13 p.Glu260Gln Uncertain significance Single submitter
- KLK13 p.Gly210Asp Uncertain significance Single submitter
- KLK13 p.Gly230Ser Uncertain significance Single submitter
- KLK13 p.Gly31Arg Uncertain significance Single submitter
- KLK13 p.Gly87Ser Uncertain significance Single submitter
- KLK13 p.His121Tyr Uncertain significance Single submitter
- KLK13 p.His147Tyr Uncertain significance Single submitter
- KLK13 p.Ile107Val Uncertain significance Single submitter
- KLK13 p.Ile262Val Uncertain significance Single submitter
- KLK13 p.Leu136Phe Uncertain significance Single submitter
- KLK13 p.Leu136Pro Uncertain significance Single submitter
- KLK13 p.Lys196Arg Uncertain significance Single submitter
- KLK13 p.Pro48Ser Uncertain significance Single submitter
- KLK13 p.Ser106Ala Uncertain significance Single submitter
- KLK13 p.Ser132Tyr Uncertain significance Single submitter
- KLK13 p.Ser23Phe Uncertain significance Single submitter
- KLK13 p.Ser33Arg Uncertain significance Single submitter
- KLK13 p.Thr117Pro Uncertain significance Single submitter
- KLK13 p.Thr156Pro Uncertain significance Single submitter
- KLK13 p.Thr261Ile Uncertain significance Single submitter
- KLK13 p.Thr32Ile Uncertain significance Single submitter
- KLK13 p.Trp2Ser Uncertain significance Single submitter
- KLK13 p.Trp49Cys Uncertain significance Single submitter
- KLK13 p.Tyr139Ser Uncertain significance Single submitter
- KLK13 p.Val104Ile Uncertain significance Single submitter
- KLK13 p.Val71Leu Uncertain significance Single submitter
- KLK13 p.Val94Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- KLK13 p.Ala75Ser Uncertain significance Single submitter
- KLK13 p.Arg184Cys Uncertain significance Single submitter
- KLK13 p.Gly38Asp Uncertain significance Single submitter
- KLK13 p.Gly38Ser Uncertain significance Single submitter
- KLK13 p.Gly63Ala Uncertain significance Single submitter
- KLK13 p.Leu151Arg Uncertain significance Single submitter
- KLK13 p.Pro110Leu Uncertain significance Single submitter
- KLK13 p.Val64Phe Uncertain significance Single submitter
All KLK13 variants
Likely benign 2
- p.Arg113Gln Single submitter
- p.Val232Ile Single submitter
Uncertain significance 56
- p.Ala179Thr Single submitter ⚠
- p.Ala52Val Single submitter
- p.Ala75Ser Single submitter ⚠
- p.Ala90Ser Single submitter ⚠
- p.Ala90Val Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Arg150His Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg184Leu Single submitter ⚠
- p.Arg190Cys Single submitter
- p.Arg244Gln Single submitter ⚠
- p.Arg244Trp Single submitter
- p.Arg250His Single submitter
- p.Arg259His Single submitter ⚠
- p.Arg259Ser Single submitter ⚠
- p.Arg263Gln Single submitter ⚠
- p.Arg58Trp Single submitter ⚠
- p.Asn148Asp Single submitter ⚠
- p.Asn30Ser Single submitter ⚠
- p.Cys77Arg Single submitter ⚠
- p.Gln131Pro Single submitter ⚠
- p.Gln191Arg Single submitter ⚠
- p.Glu260Gln Single submitter ⚠
- p.Gly210Asp Single submitter ⚠
- p.Gly230Ser Single submitter ⚠
- p.Gly31Arg Single submitter ⚠
- p.Gly38Asp Single submitter ⚠
- p.Gly38Ser Single submitter ⚠
- p.Gly63Ala Single submitter ⚠
- p.Gly87Ser Single submitter ⚠
- p.Gly92Trp Single submitter
- p.His121Tyr Single submitter ⚠
- p.His147Tyr Single submitter ⚠
- p.Ile107Val Single submitter ⚠
- p.Ile262Val Single submitter ⚠
- p.Leu136Phe Single submitter ⚠
- p.Leu136Pro Single submitter ⚠
- p.Leu151Arg Single submitter ⚠
- p.Lys196Arg Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro48Ser Single submitter ⚠
- p.Ser106Ala Single submitter ⚠
- p.Ser132Tyr Single submitter ⚠
- p.Ser23Phe Single submitter ⚠
- p.Ser33Arg Single submitter ⚠
- p.Thr117Pro Single submitter ⚠
- p.Thr156Pro Single submitter ⚠
- p.Thr261Ile Single submitter ⚠
- p.Thr32Ile Single submitter ⚠
- p.Trp2Ser Single submitter ⚠
- p.Trp49Cys Single submitter ⚠
- p.Tyr139Ser Single submitter ⚠
- p.Val104Ile Single submitter ⚠
- p.Val64Phe Single submitter ⚠
- p.Val71Leu Single submitter ⚠
- p.Val94Met Single submitter ⚠