KLK14 — 37 ClinVar variants
All ClinVar germline KLK14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
2 Conflicting · 2 Likely benign · 33 Uncertain significance
Full KLK14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLK14 c.-5C>T Uncertain significance Single submitter
- KLK14 p.Ala44Val Uncertain significance Single submitter
- KLK14 p.Arg144Pro Uncertain significance Single submitter
- KLK14 p.Arg224Cys Uncertain significance Single submitter
- KLK14 p.Arg249Leu Uncertain significance Single submitter
- KLK14 p.Arg49Cys Uncertain significance Single submitter
- KLK14 p.Arg70Cys Uncertain significance Single submitter
- KLK14 p.Arg70His Uncertain significance Single submitter
- KLK14 p.Arg96Cys Uncertain significance Single submitter
- KLK14 p.Asp21Glu Uncertain significance Single submitter
- KLK14 p.Cys189Arg Uncertain significance Single submitter
- KLK14 p.Glu246Ala Uncertain significance Single submitter
- KLK14 p.Gly205Ala Uncertain significance Single submitter
- KLK14 p.Gly28Ser Uncertain significance Single submitter
- KLK14 p.Gly59Val Uncertain significance Single submitter
- KLK14 p.Ile244Val Uncertain significance Single submitter
- KLK14 p.Ile26Phe Uncertain significance Single submitter
- KLK14 p.Lys79Glu Uncertain significance Single submitter
- KLK14 p.Pro193Ser Uncertain significance Single submitter
- KLK14 p.Pro37Leu Uncertain significance Single submitter
- KLK14 p.Thr99Met Uncertain significance Single submitter
- KLK14 p.Trp85Ser Uncertain significance Single submitter
- KLK14 p.Val10Ala Uncertain significance Single submitter
- KLK14 p.Val174Met Uncertain significance Single submitter
- KLK14 p.Val188Ile Uncertain significance Single submitter
- KLK14 p.Val94Met Uncertain significance Single submitter
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KLK14 p.Val218Met
Uncertain significance
No assertion criteria
male infertility
Predictors split 4
The independent predictors disagree with each other — read with care.
All KLK14 variants
Conflicting classifications of pathogenicity 2
- c.-23+1G>A Single submitter
- p.Ser170Phe Single submitter ⚠
Likely benign 2
- c.-22-4A>T Single submitter
- p.Ala40Val Single submitter
Uncertain significance 33
- c.40+2T>C Single submitter
- c.-5C>T Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Arg144Pro Single submitter ⚠
- p.Arg224Cys Single submitter ⚠
- p.Arg249Leu Single submitter ⚠
- p.Arg33Trp Single submitter ⚠
- p.Arg49Cys Single submitter ⚠
- p.Arg70Cys Single submitter ⚠
- p.Arg70His Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Asp21Glu Single submitter ⚠
- p.Cys189Arg Single submitter ⚠
- p.Glu246Ala Single submitter ⚠
- p.Gly140Arg Single submitter
- p.Gly205Ala Single submitter ⚠
- p.Gly28Ser Single submitter ⚠
- p.Gly59Val Single submitter ⚠
- p.Ile244Val Single submitter ⚠
- p.Ile26Phe Single submitter ⚠
- p.Lys79Glu Single submitter ⚠
- p.Pro180Leu Single submitter ⚠
- p.Pro180Thr Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Thr247Met Single submitter ⚠
- p.Thr99Met Single submitter ⚠
- p.Trp85Ser Single submitter ⚠
- p.Val10Ala Single submitter ⚠
- p.Val174Met Single submitter ⚠
- p.Val188Ile Single submitter ⚠
- p.Val94Met Single submitter ⚠
- p.Val218Met No assertion criteria male infertility ⚠