KLK2 — 47 ClinVar variants
All ClinVar germline KLK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
1 Benign · 4 Likely benign · 42 Uncertain significance
Full KLK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLK2 p.Ala185Gly Uncertain significance Single submitter
- KLK2 p.Ala199Val Uncertain significance Single submitter
- KLK2 p.Ala258Val Uncertain significance Single submitter
- KLK2 p.Ala41Thr Uncertain significance Single submitter
- KLK2 p.Arg167His Uncertain significance Single submitter
- KLK2 p.Arg24Gln Uncertain significance Single submitter
- KLK2 p.Arg77Gln Uncertain significance Single submitter
- KLK2 p.Asn181Ser Uncertain significance Single submitter
- KLK2 p.Asp255Asn Uncertain significance Single submitter
- KLK2 p.Cys152Arg Uncertain significance Single submitter
- KLK2 p.Gln22Arg Uncertain significance Single submitter
- KLK2 p.Gln22His Uncertain significance Single submitter
- KLK2 p.Glu163Gly Uncertain significance Single submitter
- KLK2 p.Gly140Asp Uncertain significance Single submitter
- KLK2 p.Gly158Asp Uncertain significance Single submitter
- KLK2 p.Gly210Arg Uncertain significance Single submitter
- KLK2 p.Gly230Arg Uncertain significance Single submitter
- KLK2 p.Gly76Ser Uncertain significance Single submitter
- KLK2 p.His108Gln Uncertain significance Single submitter
- KLK2 p.His177Arg Uncertain significance Single submitter
- KLK2 p.His49Asn Uncertain significance Single submitter
- KLK2 p.Ile21Met Uncertain significance Single submitter
- KLK2 p.Leu111Phe Uncertain significance Single submitter
- KLK2 p.Leu139Pro Uncertain significance Single submitter
- KLK2 p.Met122Leu Uncertain significance Single submitter
- KLK2 p.Pro240Ser Uncertain significance Single submitter
- KLK2 p.Ser104Asn Uncertain significance Single submitter
- KLK2 p.Ser127Leu Uncertain significance Single submitter
- KLK2 p.Ser23Pro Uncertain significance Single submitter
- KLK2 p.Thr203Arg Uncertain significance Single submitter
- KLK2 p.Tyr153Cys Uncertain significance Single submitter
- KLK2 p.Val135Ile Uncertain significance Single submitter
- KLK2 p.Val138Ile Uncertain significance Single submitter
- KLK2 p.Val55Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- KLK2 p.His34Arg Uncertain significance Single submitter
- KLK2 p.His98Tyr Uncertain significance Single submitter
- KLK2 p.Leu75Val Uncertain significance Single submitter
- KLK2 p.Lys245Asn Uncertain significance Single submitter
- KLK2 p.Met122Thr Uncertain significance Single submitter
- KLK2 p.Trp47Cys Uncertain significance Single submitter
All KLK2 variants
Benign 1
- p.Arg250Trp Single submitter acute myeloid leukemia
Likely benign 4
- p.Arg169Lys Single submitter
- p.Ser180Pro Single submitter
- p.Val12Leu Single submitter
- p.Val218Ile Single submitter
Uncertain significance 42
- p.Ala185Gly Single submitter ⚠
- p.Ala199Val Single submitter ⚠
- p.Ala258Val Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Arg167His Single submitter ⚠
- p.Arg24Gln Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Asn181Ser Single submitter ⚠
- p.Asp255Asn Single submitter ⚠
- p.Cys152Arg Single submitter ⚠
- p.Gln22Arg Single submitter ⚠
- p.Gln22His Single submitter ⚠
- p.Glu163Gly Single submitter ⚠
- p.Gly140Asp Single submitter ⚠
- p.Gly158Asp Single submitter ⚠
- p.Gly210Arg Single submitter ⚠
- p.Gly230Arg Single submitter ⚠
- p.Gly76Ser Single submitter ⚠
- p.His108Gln Single submitter ⚠
- p.His177Arg Single submitter ⚠
- p.His34Arg Single submitter ⚠
- p.His49Asn Single submitter ⚠
- p.His98Tyr Single submitter ⚠
- p.Ile21Met Single submitter ⚠
- p.Leu111Phe Single submitter ⚠
- p.Leu139Pro Single submitter ⚠
- p.Leu75Val Single submitter ⚠
- p.Lys245Asn Single submitter ⚠
- p.Lys33Asn Single submitter
- p.Met122Leu Single submitter ⚠
- p.Met122Thr Single submitter ⚠
- p.Pro240Ser Single submitter ⚠
- p.Ser104Asn Single submitter ⚠
- p.Ser127Leu Single submitter ⚠
- p.Ser23Pro Single submitter ⚠
- p.Thr203Arg Single submitter ⚠
- p.Thr227Ile Single submitter
- p.Trp47Cys Single submitter ⚠
- p.Tyr153Cys Single submitter ⚠
- p.Val135Ile Single submitter ⚠
- p.Val138Ile Single submitter ⚠
- p.Val55Leu Single submitter ⚠