Sugi Variant

Sugi Variant/KRT86

KRT86 — 156 ClinVar variants

All ClinVar germline KRT86 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →

5 Pathogenic · 1 Likely pathogenic · 40 Benign · 5 Benign/Likely benign · 25 Likely benign · 80 Uncertain significance

Full KRT86 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 72

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 58

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 14

The independent predictors disagree with each other — read with care.

All KRT86 variants

Pathogenic 5

Likely pathogenic 1

Benign 40

Benign/Likely benign 5

Likely benign 25

Uncertain significance 80