LANCL1 — 70 ClinVar variants
All ClinVar germline LANCL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
2 Benign · 68 Uncertain significance
Full LANCL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LANCL1 p.Ala115Val Uncertain significance Single submitter
- LANCL1 p.Ala147Asp Uncertain significance Single submitter
- LANCL1 p.Ala18Val Uncertain significance Single submitter
- LANCL1 p.Ala222Thr Uncertain significance Single submitter
- LANCL1 p.Ala279Ser Uncertain significance Single submitter
- LANCL1 p.Ala331Gly Uncertain significance Single submitter
- LANCL1 p.Ala348Ser Uncertain significance Single submitter
- LANCL1 p.Ala5Gly Uncertain significance Single submitter
- LANCL1 p.Ala66Thr Uncertain significance Single submitter
- LANCL1 p.Ala69Ser Uncertain significance Single submitter
- LANCL1 p.Ala83Thr Uncertain significance Single submitter
- LANCL1 p.Arg155Gln Uncertain significance Single submitter
- LANCL1 p.Arg269Gln Uncertain significance Single submitter
- LANCL1 p.Arg57Gln Uncertain significance Single submitter
- LANCL1 p.Arg57Trp Uncertain significance Single submitter
- LANCL1 p.Asn337Ser Uncertain significance Single submitter
- LANCL1 p.Cys133Arg Uncertain significance Single submitter
- LANCL1 p.Gln311Lys Uncertain significance Single submitter
- LANCL1 p.Gln45His Uncertain significance Single submitter
- LANCL1 p.Gln94Arg Uncertain significance Single submitter
- LANCL1 p.Glu172Asp Uncertain significance Single submitter
- LANCL1 p.Glu19Lys Uncertain significance Single submitter
- LANCL1 p.Glu31Lys Uncertain significance Single submitter
- LANCL1 p.Gly324Ser Uncertain significance Single submitter
- LANCL1 p.Gly375Glu Uncertain significance Single submitter
- LANCL1 p.Gly61Ala Uncertain significance Single submitter
- LANCL1 p.Gly64Ala Uncertain significance Single submitter
- LANCL1 p.His122Asn Uncertain significance Single submitter
- LANCL1 p.His219Tyr Uncertain significance Single submitter
- LANCL1 p.His274Tyr Uncertain significance Single submitter
- LANCL1 p.His323Pro Uncertain significance Single submitter
- LANCL1 p.His323Tyr Uncertain significance Single submitter
- LANCL1 p.His89Tyr Uncertain significance Single submitter
- LANCL1 p.Leu71Phe Uncertain significance Single submitter
- LANCL1 p.Leu96Val Uncertain significance Single submitter
- LANCL1 p.Lys291Glu Uncertain significance Single submitter
- LANCL1 p.Lys52Arg Uncertain significance Single submitter
- LANCL1 p.Met285Val Uncertain significance Single submitter
- LANCL1 p.Phe373Leu Uncertain significance Single submitter
- LANCL1 p.Phe79Ser Uncertain significance Single submitter
- LANCL1 p.Pro257Ser Uncertain significance Single submitter
- LANCL1 p.Pro7Leu Uncertain significance Single submitter
- LANCL1 p.Pro9Ser Uncertain significance Single submitter
- LANCL1 p.Ser177Arg Uncertain significance Single submitter
- LANCL1 p.Tyr160Cys Uncertain significance Single submitter
- LANCL1 p.Tyr303Cys Uncertain significance Single submitter
- LANCL1 p.Tyr312Cys Uncertain significance Single submitter
- LANCL1 p.Tyr330Cys Uncertain significance Single submitter
- LANCL1 p.Tyr62Asp Uncertain significance Single submitter
- LANCL1 p.Val292Leu Uncertain significance Single submitter
- LANCL1 p.Val92Glu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- LANCL1 p.Ala117Thr Uncertain significance Single submitter
- LANCL1 p.Ala118Thr Uncertain significance Single submitter
- LANCL1 p.Ala279Thr Uncertain significance Single submitter
- LANCL1 p.Arg136Trp Uncertain significance Single submitter
- LANCL1 p.Asn166Ser Uncertain significance Single submitter
- LANCL1 p.His361Arg Uncertain significance Single submitter
- LANCL1 p.Ile68Thr Uncertain significance Single submitter
- LANCL1 p.Leu240Phe Uncertain significance Single submitter
- LANCL1 p.Leu51Gln Uncertain significance Single submitter
- LANCL1 p.Lys39Glu Uncertain significance Single submitter
- LANCL1 p.Met151Thr Uncertain significance Single submitter
- LANCL1 p.Phe164Leu Uncertain significance Single submitter
- LANCL1 p.Tyr10Cys Uncertain significance Single submitter
- LANCL1 p.Tyr336Cys Uncertain significance Single submitter
All LANCL1 variants
Benign 2
- p.Arg41= Multiple submitters
- p.Ile138Met Single submitter
Uncertain significance 68
- p.Ala115Val Single submitter ⚠
- p.Ala117Thr Single submitter ⚠
- p.Ala118Thr Single submitter ⚠
- p.Ala147Asp Single submitter ⚠
- p.Ala18Val Single submitter ⚠
- p.Ala222Thr Single submitter ⚠
- p.Ala279Ser Single submitter ⚠
- p.Ala279Thr Single submitter ⚠
- p.Ala331Gly Single submitter ⚠
- p.Ala348Ser Single submitter ⚠
- p.Ala5Gly Single submitter ⚠
- p.Ala66Thr Single submitter ⚠
- p.Ala69Ser Single submitter ⚠
- p.Ala83Thr Single submitter ⚠
- p.Arg136Trp Single submitter ⚠
- p.Arg155Gln Single submitter ⚠
- p.Arg269Gln Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg57Trp Single submitter ⚠
- p.Asn166Ser Single submitter ⚠
- p.Asn337Ser Single submitter ⚠
- p.Cys133Arg Single submitter ⚠
- p.Gln311Lys Single submitter ⚠
- p.Gln45His Single submitter ⚠
- p.Gln94Arg Single submitter ⚠
- p.Glu172Asp Single submitter ⚠
- p.Glu19Lys Single submitter ⚠
- p.Glu31Lys Single submitter ⚠
- p.Gly26Arg Single submitter
- p.Gly324Ser Single submitter ⚠
- p.Gly375Glu Single submitter ⚠
- p.Gly61Ala Single submitter ⚠
- p.Gly64Ala Single submitter ⚠
- p.Gly80Val Single submitter
- p.His122Asn Single submitter ⚠
- p.His219Tyr Single submitter ⚠
- p.His274Tyr Single submitter ⚠
- p.His323Pro Single submitter ⚠
- p.His323Tyr Single submitter ⚠
- p.His361Arg Single submitter ⚠
- p.His89Tyr Single submitter ⚠
- p.Ile68Phe Single submitter
- p.Ile68Thr Single submitter ⚠
- p.Leu240Phe Single submitter ⚠
- p.Leu51Gln Single submitter ⚠
- p.Leu71Phe Single submitter ⚠
- p.Leu96Val Single submitter ⚠
- p.Lys291Glu Single submitter ⚠
- p.Lys39Glu Single submitter ⚠
- p.Lys52Arg Single submitter ⚠
- p.Met151Thr Single submitter ⚠
- p.Met285Val Single submitter ⚠
- p.Phe164Leu Single submitter ⚠
- p.Phe373Leu Single submitter ⚠
- p.Phe79Ser Single submitter ⚠
- p.Pro257Ser Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Pro9Ser Single submitter ⚠
- p.Ser177Arg Single submitter ⚠
- p.Tyr10Cys Single submitter ⚠
- p.Tyr160Cys Single submitter ⚠
- p.Tyr303Cys Single submitter ⚠
- p.Tyr312Cys Single submitter ⚠
- p.Tyr330Cys Single submitter ⚠
- p.Tyr336Cys Single submitter ⚠
- p.Tyr62Asp Single submitter ⚠
- p.Val292Leu Single submitter ⚠
- p.Val92Glu Single submitter ⚠