LATS1 — 110 ClinVar variants
All ClinVar germline LATS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
1 Pathogenic · 2 Likely pathogenic · 1 Benign · 4 Likely benign · 102 Uncertain significance
Full LATS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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LATS1 p.Lys125Asn
Pathogenic
No assertion criteria
myoepithelial tumor
Predictors lean, ClinVar uncertain 84
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LATS1 p.Ala156Gly Uncertain significance Single submitter
- LATS1 p.Ala395Thr Uncertain significance Single submitter
- LATS1 p.Ala898Val Uncertain significance Single submitter
- LATS1 p.Arg147Pro Uncertain significance Single submitter
- LATS1 p.Arg148Gly Uncertain significance Single submitter
- LATS1 p.Arg174His Uncertain significance Single submitter
- LATS1 p.Arg28Gly Uncertain significance Single submitter
- LATS1 p.Arg370Gln Uncertain significance Single submitter
- LATS1 p.Arg370Trp Uncertain significance Single submitter
- LATS1 p.Arg502His Uncertain significance Single submitter
- LATS1 p.Arg806Gln Uncertain significance Single submitter
- LATS1 p.Asn369Asp Uncertain significance Single submitter
- LATS1 p.Asn402His Uncertain significance Single submitter
- LATS1 p.Asn423Asp Uncertain significance Single submitter
- LATS1 p.Asn877Ser Uncertain significance Single submitter
- LATS1 p.Asn90Asp Uncertain significance Single submitter
- LATS1 p.Asn93Asp Uncertain significance Single submitter
- LATS1 p.Asn964His Uncertain significance Single submitter
- LATS1 p.Asp1002Asn Uncertain significance Single submitter
- LATS1 p.Asp1014Asn Uncertain significance Single submitter
- LATS1 p.Asp210Glu Uncertain significance Single submitter
- LATS1 p.Asp46Tyr Uncertain significance Single submitter
- LATS1 p.Asp604Gly Uncertain significance Single submitter
- LATS1 p.Asp837Gly Uncertain significance Single submitter
- LATS1 p.Asp858Asn Uncertain significance Single submitter
- LATS1 p.Asp858Tyr Uncertain significance Single submitter
- LATS1 p.Gln29His Uncertain significance Single submitter
- LATS1 p.Gln553Glu Uncertain significance Single submitter
- LATS1 p.Gln632Arg Uncertain significance Single submitter
- LATS1 p.Glu450Lys Uncertain significance Single submitter
- LATS1 p.Glu574Lys Uncertain significance Single submitter
- LATS1 p.Glu598Gly Uncertain significance Single submitter
- LATS1 p.Gly166Glu Uncertain significance Single submitter
- LATS1 p.Gly279Val Uncertain significance Single submitter
- LATS1 p.Gly403Glu Uncertain significance Single submitter
- LATS1 p.Gly937Asp Uncertain significance Single submitter
- LATS1 p.His449Arg Uncertain significance Single submitter
- LATS1 p.His646Arg Uncertain significance Single submitter
- LATS1 p.His826Asn Uncertain significance Single submitter
- LATS1 p.Ile159Val Uncertain significance Single submitter
- LATS1 p.Ile220Leu Uncertain significance Single submitter
- LATS1 p.Ile285Val Uncertain significance Single submitter
- LATS1 p.Ile330Val Uncertain significance Single submitter
- LATS1 p.Ile358Val Uncertain significance Single submitter
- LATS1 p.Ile494Val Uncertain significance Single submitter
- LATS1 p.Ile713Val Uncertain significance Single submitter
- LATS1 p.Lys1123Glu Uncertain significance Single submitter
- LATS1 p.Lys699Glu Uncertain significance Single submitter
- LATS1 p.Lys724Asn Uncertain significance Single submitter
- LATS1 p.Lys76Glu Uncertain significance Single submitter
- LATS1 p.Met151Thr Uncertain significance Single submitter
- LATS1 p.Pro146Ser Uncertain significance Single submitter
- LATS1 p.Pro192Leu Uncertain significance Single submitter
- LATS1 p.Pro205Ser Uncertain significance Single submitter
- LATS1 p.Pro239Ser Uncertain significance Single submitter
- LATS1 p.Pro250Leu Uncertain significance Single submitter
- LATS1 p.Pro251Leu Uncertain significance Single submitter
- LATS1 p.Pro270Ser Uncertain significance Single submitter
- LATS1 p.Pro377His Uncertain significance Single submitter
- LATS1 p.Pro445Arg Uncertain significance Single submitter
- LATS1 p.Pro529Ala Uncertain significance Single submitter
- LATS1 p.Pro557Ser Uncertain significance Single submitter
- LATS1 p.Ser1111Leu Uncertain significance Single submitter
- LATS1 p.Ser171Leu Uncertain significance Single submitter
- LATS1 p.Ser27Gly Uncertain significance Single submitter
- LATS1 p.Ser398Leu Uncertain significance Single submitter
- LATS1 p.Ser416Asn Uncertain significance Single submitter
- LATS1 p.Ser474Asn Uncertain significance Single submitter
- LATS1 p.Ser4Thr Uncertain significance Single submitter
- LATS1 p.Ser596Asn Uncertain significance Single submitter
- LATS1 p.Ser690Tyr Uncertain significance Single submitter
- LATS1 p.Ser95Phe Uncertain significance Single submitter
- LATS1 p.Ser97Asn Uncertain significance Single submitter
- LATS1 p.Thr126Ser Uncertain significance Single submitter
- LATS1 p.Thr401Ile Uncertain significance Single submitter
- LATS1 p.Thr515Ala Uncertain significance Single submitter
- LATS1 p.Thr526Ile Uncertain significance Single submitter
- LATS1 p.Thr967Ser Uncertain significance Single submitter
- LATS1 p.Val1128Ile Uncertain significance Single submitter
- LATS1 p.Val323Leu Uncertain significance Single submitter
- LATS1 p.Val570Leu Uncertain significance Single submitter
- LATS1 p.Val65Phe Uncertain significance Single submitter
-
LATS1 p.Ala677Ser
Uncertain significance
No assertion criteria
teratoma
-
LATS1 p.Asp789His
Uncertain significance
No assertion criteria
ependymoma
Predictors split 13
The independent predictors disagree with each other — read with care.
- LATS1 p.Arg174Leu Uncertain significance Single submitter
- LATS1 p.Arg252Gly Uncertain significance Single submitter
- LATS1 p.Arg276Cys Uncertain significance Single submitter
- LATS1 p.Arg630Cys Uncertain significance Single submitter
- LATS1 p.Arg869Trp Uncertain significance Single submitter
- LATS1 p.Arg924Gln Uncertain significance Single submitter
- LATS1 p.Gly1000Ser Uncertain significance Single submitter
- LATS1 p.His1070Gln Uncertain significance Single submitter
- LATS1 p.Ile34Val Uncertain significance Single submitter
- LATS1 p.Lys561Glu Uncertain significance Single submitter
- LATS1 p.Phe340Leu Uncertain significance Single submitter
- LATS1 p.Pro263Leu Uncertain significance Single submitter
- LATS1 p.Thr485Ile Uncertain significance Single submitter
All LATS1 variants
Pathogenic 1
- p.Lys125Asn No assertion criteria myoepithelial tumor ⚠
Likely pathogenic 2
- p.Glu817Lys No assertion criteria plasma cell myeloma
- p.Trp879Ter No assertion criteria malignant peritoneal mesothelioma
Benign 1
- p.Ser204Gly Single submitter
Likely benign 4
- p.Pro531Ser Multiple submitters
- p.Ala473Thr Single submitter
- p.Arg96Trp Single submitter
- p.Leu849= Single submitter
Uncertain significance 102
- p.Ala156Gly Single submitter ⚠
- p.Ala395Thr Single submitter ⚠
- p.Ala898Val Single submitter ⚠
- p.Arg147Pro Single submitter ⚠
- p.Arg148Gly Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg174Leu Single submitter ⚠
- p.Arg252Gly Single submitter ⚠
- p.Arg276Cys Single submitter ⚠
- p.Arg28Gly Single submitter ⚠
- p.Arg370Gln Single submitter ⚠
- p.Arg370Trp Single submitter ⚠
- p.Arg502His Single submitter ⚠
- p.Arg630Cys Single submitter ⚠
- p.Arg737Gln Single submitter
- p.Arg744Ter Single submitter
- p.Arg806Gln Single submitter ⚠
- p.Arg869Trp Single submitter ⚠
- p.Arg924Gln Single submitter ⚠
- p.Asn369Asp Single submitter ⚠
- p.Asn402His Single submitter ⚠
- p.Asn423Asp Single submitter ⚠
- p.Asn877Ser Single submitter ⚠
- p.Asn90Asp Single submitter ⚠
- p.Asn93Asp Single submitter ⚠
- p.Asn964His Single submitter ⚠
- p.Asp1002Asn Single submitter ⚠
- p.Asp1014Asn Single submitter ⚠
- p.Asp210Glu Single submitter ⚠
- p.Asp46Tyr Single submitter ⚠
- p.Asp604Gly Single submitter ⚠
- p.Asp837Gly Single submitter ⚠
- p.Asp858Asn Single submitter ⚠
- p.Asp858Tyr Single submitter ⚠
- p.Gln29His Single submitter ⚠
- p.Gln553Glu Single submitter ⚠
- p.Gln632Arg Single submitter ⚠
- p.Glu450Lys Single submitter ⚠
- p.Glu574Lys Single submitter ⚠
- p.Glu598Gly Single submitter ⚠
- p.Gly1000Ser Single submitter ⚠
- p.Gly166Glu Single submitter ⚠
- p.Gly279Val Single submitter ⚠
- p.Gly403Glu Single submitter ⚠
- p.Gly937Asp Single submitter ⚠
- p.His1070Gln Single submitter ⚠
- p.His449Arg Single submitter ⚠
- p.His646Arg Single submitter ⚠
- p.His826Asn Single submitter ⚠
- p.Ile120fs Single submitter
- p.Ile159Val Single submitter ⚠
- p.Ile220Leu Single submitter ⚠
- p.Ile285Val Single submitter ⚠
- p.Ile330Val Single submitter ⚠
- p.Ile34Val Single submitter ⚠
- p.Ile358Val Single submitter ⚠
- p.Ile494Val Single submitter ⚠
- p.Ile713Val Single submitter ⚠
- p.Lys1123Glu Single submitter ⚠
- p.Lys561Glu Single submitter ⚠
- p.Lys699Glu Single submitter ⚠
- p.Lys724Asn Single submitter ⚠
- p.Lys76Glu Single submitter ⚠
- p.Met151Thr Single submitter ⚠
- p.Phe340Leu Single submitter ⚠
- p.Pro146Ser Single submitter ⚠
- p.Pro192Leu Single submitter ⚠
- p.Pro205Ser Single submitter ⚠
- p.Pro239Ser Single submitter ⚠
- p.Pro250Leu Single submitter ⚠
- p.Pro251Leu Single submitter ⚠
- p.Pro263Leu Single submitter ⚠
- p.Pro270Ser Single submitter ⚠
- p.Pro377His Single submitter ⚠
- p.Pro445Arg Single submitter ⚠
- p.Pro529Ala Single submitter ⚠
- p.Pro557Ser Single submitter ⚠
- p.Ser1111Leu Single submitter ⚠
- p.Ser171Leu Single submitter ⚠
- p.Ser27Gly Single submitter ⚠
- p.Ser398Leu Single submitter ⚠
- p.Ser416Asn Single submitter ⚠
- p.Ser474Asn Single submitter ⚠
- p.Ser4Thr Single submitter ⚠
- p.Ser596Asn Single submitter ⚠
- p.Ser635Cys Single submitter
- p.Ser690Tyr Single submitter ⚠
- p.Ser95Phe Single submitter ⚠
- p.Ser97Asn Single submitter ⚠
- p.Thr126Ser Single submitter ⚠
- p.Thr401Ile Single submitter ⚠
- p.Thr485Ile Single submitter ⚠
- p.Thr487Pro Single submitter
- p.Thr515Ala Single submitter ⚠
- p.Thr526Ile Single submitter ⚠
- p.Thr967Ser Single submitter ⚠
- p.Val1128Ile Single submitter ⚠
- p.Val323Leu Single submitter ⚠
- p.Val570Leu Single submitter ⚠
- p.Val65Phe Single submitter ⚠
- p.Ala677Ser No assertion criteria teratoma ⚠
- p.Asp789His No assertion criteria ependymoma ⚠