LCLAT1 — 52 ClinVar variants
All ClinVar germline LCLAT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
4 Likely benign · 48 Uncertain significance
Full LCLAT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LCLAT1 c.-5+12285A>G Uncertain significance Single submitter
- LCLAT1 c.-5+12305A>G Uncertain significance Single submitter
- LCLAT1 c.-5+12306C>G Uncertain significance Single submitter
- LCLAT1 p.Ala359Val Uncertain significance Single submitter
- LCLAT1 p.Ala56Thr Uncertain significance Single submitter
- LCLAT1 p.Arg176Gln Uncertain significance Single submitter
- LCLAT1 p.Arg269Gln Uncertain significance Single submitter
- LCLAT1 p.Arg276Lys Uncertain significance Single submitter
- LCLAT1 p.Arg86Gln Uncertain significance Single submitter
- LCLAT1 p.Asn35Lys Uncertain significance Single submitter
- LCLAT1 p.Asp149Gly Uncertain significance Single submitter
- LCLAT1 p.Glu145Lys Uncertain significance Single submitter
- LCLAT1 p.Glu271Gln Uncertain significance Single submitter
- LCLAT1 p.Gly6Arg Uncertain significance Single submitter
- LCLAT1 p.His134Arg Uncertain significance Single submitter
- LCLAT1 p.His217Arg Uncertain significance Single submitter
- LCLAT1 p.His225Tyr Uncertain significance Single submitter
- LCLAT1 p.His369Arg Uncertain significance Single submitter
- LCLAT1 p.Ile109Val Uncertain significance Single submitter
- LCLAT1 p.Ile22Val Uncertain significance Single submitter
- LCLAT1 p.Ile326Met Uncertain significance Single submitter
- LCLAT1 p.Ile342Met Uncertain significance Single submitter
- LCLAT1 p.Ile349Thr Uncertain significance Single submitter
- LCLAT1 p.Leu29Phe Uncertain significance Single submitter
- LCLAT1 p.Leu302Pro Uncertain significance Single submitter
- LCLAT1 p.Lys141Arg Uncertain significance Single submitter
- LCLAT1 p.Lys285Asn Uncertain significance Single submitter
- LCLAT1 p.Met147Val Uncertain significance Single submitter
- LCLAT1 p.Met322Val Uncertain significance Single submitter
- LCLAT1 p.Phe132Ile Uncertain significance Single submitter
- LCLAT1 p.Phe93Ser Uncertain significance Single submitter
- LCLAT1 p.Ser293Arg Uncertain significance Single submitter
- LCLAT1 p.Ser79Thr Uncertain significance Single submitter
- LCLAT1 p.Thr12Ile Uncertain significance Single submitter
- LCLAT1 p.Thr257Ala Uncertain significance Single submitter
- LCLAT1 p.Thr69Ser Uncertain significance Single submitter
- LCLAT1 p.Val204Ile Uncertain significance Single submitter
- LCLAT1 p.Val304Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- LCLAT1 p.Arg45Cys Uncertain significance Single submitter
- LCLAT1 p.Gly185Glu Uncertain significance Single submitter
- LCLAT1 p.Gly291Arg Uncertain significance Single submitter
- LCLAT1 p.Ile82Leu Uncertain significance Single submitter
- LCLAT1 p.Phe350Leu Uncertain significance Single submitter
- LCLAT1 p.Phe93Leu Uncertain significance Single submitter
- LCLAT1 p.Val192Leu Uncertain significance Single submitter
All LCLAT1 variants
Likely benign 4
- c.-5+12278A>G Single submitter
- c.-5+12306C>T Single submitter
- p.Gly117Ser Single submitter
- p.Val34Ile Single submitter
Uncertain significance 48
- c.-5+12285A>G Single submitter ⚠
- c.-5+12305A>G Single submitter ⚠
- c.-5+12306C>G Single submitter ⚠
- p.Ala359Val Single submitter ⚠
- p.Ala56Thr Single submitter ⚠
- p.Arg176Gln Single submitter ⚠
- p.Arg269Gln Single submitter ⚠
- p.Arg276Lys Single submitter ⚠
- p.Arg45Cys Single submitter ⚠
- p.Arg86Gln Single submitter ⚠
- p.Asn184Lys Single submitter
- p.Asn35Lys Single submitter ⚠
- p.Asp149Gly Single submitter ⚠
- p.Glu145Lys Single submitter ⚠
- p.Glu271Gln Single submitter ⚠
- p.Gly185Glu Single submitter ⚠
- p.Gly291Arg Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.His134Arg Single submitter ⚠
- p.His217Arg Single submitter ⚠
- p.His225Tyr Single submitter ⚠
- p.His369Arg Single submitter ⚠
- p.Ile109Val Single submitter ⚠
- p.Ile22Val Single submitter ⚠
- p.Ile326Met Single submitter ⚠
- p.Ile342Met Single submitter ⚠
- p.Ile349Thr Single submitter ⚠
- p.Ile82Leu Single submitter ⚠
- p.Leu29Phe Single submitter ⚠
- p.Leu302Pro Single submitter ⚠
- p.Lys141Arg Single submitter ⚠
- p.Lys285Asn Single submitter ⚠
- p.Met147Val Single submitter ⚠
- p.Met322Val Single submitter ⚠
- p.Phe132Ile Single submitter ⚠
- p.Phe350Leu Single submitter ⚠
- p.Phe93Leu Single submitter ⚠
- p.Phe93Ser Single submitter ⚠
- p.Pro36Ser Single submitter
- p.Ser293Arg Single submitter ⚠
- p.Ser79Thr Single submitter ⚠
- p.Thr12Ile Single submitter ⚠
- p.Thr257Ala Single submitter ⚠
- p.Thr52Ser Single submitter
- p.Thr69Ser Single submitter ⚠
- p.Val192Leu Single submitter ⚠
- p.Val204Ile Single submitter ⚠
- p.Val304Ile Single submitter ⚠