LGALS1 — 20 ClinVar variants
All ClinVar germline LGALS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
1 Likely benign · 19 Uncertain significance
Full LGALS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LGALS1 p.Ala25Ser Uncertain significance Single submitter
- LGALS1 p.Ala52Thr Uncertain significance Single submitter
- LGALS1 p.Ala68Asp Uncertain significance Single submitter
- LGALS1 p.Arg49Cys Uncertain significance Single submitter
- LGALS1 p.Arg49Leu Uncertain significance Single submitter
- LGALS1 p.Asp65Asn Uncertain significance Single submitter
- LGALS1 p.Gly22Ser Uncertain significance Single submitter
- LGALS1 p.Gly66Ser Uncertain significance Single submitter
- LGALS1 p.His53Tyr Uncertain significance Single submitter
- LGALS1 p.Ile59Phe Uncertain significance Single submitter
- LGALS1 p.Phe31Leu Uncertain significance Single submitter
- LGALS1 p.Thr58Ser Uncertain significance Single submitter
- LGALS1 p.Val32Met Uncertain significance Single submitter
- LGALS1 p.Val60Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All LGALS1 variants
Likely benign 1
- p.Val99Ile Single submitter
Uncertain significance 19
- p.Ala25Ser Single submitter ⚠
- p.Ala28Thr Single submitter ⚠
- p.Ala52Thr Single submitter ⚠
- p.Ala68Asp Single submitter ⚠
- p.Arg49Cys Single submitter ⚠
- p.Arg49Leu Single submitter ⚠
- p.Asn111Ser Single submitter ⚠
- p.Asp65Asn Single submitter ⚠
- p.Gly125Ser Single submitter
- p.Gly22Ser Single submitter ⚠
- p.Gly66Ser Single submitter ⚠
- p.Gly67Arg Single submitter ⚠
- p.His53Tyr Single submitter ⚠
- p.Ile59Phe Single submitter ⚠
- p.Phe127Leu Single submitter ⚠
- p.Phe31Leu Single submitter ⚠
- p.Thr58Ser Single submitter ⚠
- p.Val32Met Single submitter ⚠
- p.Val60Met Single submitter ⚠