LGALS2 — 24 ClinVar variants
All ClinVar germline LGALS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Benign · 3 Likely benign · 20 Uncertain significance
Full LGALS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LGALS2 p.Arg108Met Uncertain significance Single submitter
- LGALS2 p.Asn43His Uncertain significance Single submitter
- LGALS2 p.Asp26Asn Uncertain significance Single submitter
- LGALS2 p.Asp99Asn Uncertain significance Single submitter
- LGALS2 p.Glu68Gly Uncertain significance Single submitter
- LGALS2 p.Gly110Asp Uncertain significance Single submitter
- LGALS2 p.His101Tyr Uncertain significance Single submitter
- LGALS2 p.Ile55Val Uncertain significance Single submitter
- LGALS2 p.Leu35Pro Uncertain significance Single submitter
- LGALS2 p.Ser53Cys Uncertain significance Single submitter
- LGALS2 p.Thr17Ile Uncertain significance Single submitter
- LGALS2 p.Thr2Ala Uncertain significance Single submitter
- LGALS2 p.Val32Leu Uncertain significance Single submitter
- LGALS2 p.Val56Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- LGALS2 p.Arg49Cys Uncertain significance Single submitter
- LGALS2 p.Glu52Lys Uncertain significance Single submitter
- LGALS2 p.Gly66Ala Uncertain significance Single submitter
- LGALS2 p.Met125Lys Uncertain significance Single submitter
- LGALS2 p.Phe93Leu Uncertain significance Single submitter
- LGALS2 p.Thr104Pro Uncertain significance Single submitter
All LGALS2 variants
Benign 1
- p.Thr87Ile Multiple submitters
Likely benign 3
- p.Thr21Lys Single submitter
- p.Val7Ile Single submitter
- p.Leu60= No assertion criteria LGALS2-related disorder
Uncertain significance 20
- p.Arg108Met Single submitter ⚠
- p.Arg49Cys Single submitter ⚠
- p.Asn43His Single submitter ⚠
- p.Asp26Asn Single submitter ⚠
- p.Asp99Asn Single submitter ⚠
- p.Glu52Lys Single submitter ⚠
- p.Glu68Gly Single submitter ⚠
- p.Gly110Asp Single submitter ⚠
- p.Gly66Ala Single submitter ⚠
- p.His101Tyr Single submitter ⚠
- p.Ile55Val Single submitter ⚠
- p.Leu35Pro Single submitter ⚠
- p.Met125Lys Single submitter ⚠
- p.Phe93Leu Single submitter ⚠
- p.Ser53Cys Single submitter ⚠
- p.Thr104Pro Single submitter ⚠
- p.Thr17Ile Single submitter ⚠
- p.Thr2Ala Single submitter ⚠
- p.Val32Leu Single submitter ⚠
- p.Val56Ala Single submitter ⚠