LGALS4 — 48 ClinVar variants
All ClinVar germline LGALS4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
1 Benign · 4 Likely benign · 43 Uncertain significance
Full LGALS4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LGALS4 p.Ala289Thr Uncertain significance Single submitter
- LGALS4 p.Ala61Thr Uncertain significance Single submitter
- LGALS4 p.Arg156Trp Uncertain significance Single submitter
- LGALS4 p.Arg284His Uncertain significance Single submitter
- LGALS4 p.Arg67Trp Uncertain significance Single submitter
- LGALS4 p.Asp59Tyr Uncertain significance Single submitter
- LGALS4 p.Gly244Ala Uncertain significance Single submitter
- LGALS4 p.Gly244Ser Uncertain significance Single submitter
- LGALS4 p.Gly70Ser Uncertain significance Single submitter
- LGALS4 p.His173Arg Uncertain significance Single submitter
- LGALS4 p.Ile210Leu Uncertain significance Single submitter
- LGALS4 p.Ile237Met Uncertain significance Single submitter
- LGALS4 p.Met182Val Uncertain significance Single submitter
- LGALS4 p.Phe121Val Uncertain significance Single submitter
- LGALS4 p.Phe274Leu Uncertain significance Single submitter
- LGALS4 p.Pro154Ser Uncertain significance Single submitter
- LGALS4 p.Pro161Leu Uncertain significance Single submitter
- LGALS4 p.Pro164Thr Uncertain significance Single submitter
- LGALS4 p.Pro167Ser Uncertain significance Single submitter
- LGALS4 p.Pro56Leu Uncertain significance Single submitter
- LGALS4 p.Ser40Arg Uncertain significance Single submitter
- LGALS4 p.Ser92Asn Uncertain significance Single submitter
- LGALS4 p.Thr264Asn Uncertain significance Single submitter
- LGALS4 p.Trp71Gly Uncertain significance Single submitter
- LGALS4 p.Tyr19Asp Uncertain significance Single submitter
- LGALS4 p.Val104Leu Uncertain significance Single submitter
- LGALS4 p.Val246Met Uncertain significance Single submitter
- LGALS4 p.Val48Met Uncertain significance Single submitter
- LGALS4 p.Val74Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- LGALS4 p.Arg240His Uncertain significance Single submitter
- LGALS4 p.Asn77Ser Uncertain significance Single submitter
- LGALS4 p.Gly151Arg Uncertain significance Single submitter
- LGALS4 p.Met93Thr Uncertain significance Single submitter
- LGALS4 p.Phe105Leu Uncertain significance Single submitter
- LGALS4 p.Phe273Leu Uncertain significance Single submitter
- LGALS4 p.Pro11Leu Uncertain significance Single submitter
- LGALS4 p.Pro190Leu Uncertain significance Single submitter
- LGALS4 p.Pro7Leu Uncertain significance Single submitter
- LGALS4 p.Ser250Gly Uncertain significance Single submitter
- LGALS4 p.Thr78Met Uncertain significance Single submitter
- LGALS4 p.Tyr34Asp Uncertain significance Single submitter
All LGALS4 variants
Benign 1
- p.Thr16Met Multiple submitters
Likely benign 4
- p.Ala2= Multiple submitters
- p.Arg89Lys Single submitter
- p.Leu301Phe Single submitter
- p.Met241Leu Single submitter
Uncertain significance 43
- p.Ala289Thr Single submitter ⚠
- p.Ala61Thr Single submitter ⚠
- p.Arg156Trp Single submitter ⚠
- p.Arg240His Single submitter ⚠
- p.Arg248Gln Single submitter
- p.Arg284His Single submitter ⚠
- p.Arg67Trp Single submitter ⚠
- p.Asn77Ser Single submitter ⚠
- p.Asp59Tyr Single submitter ⚠
- p.Gly151Arg Single submitter ⚠
- p.Gly244Ala Single submitter ⚠
- p.Gly244Ser Single submitter ⚠
- p.Gly271Arg Single submitter
- p.Gly70Ser Single submitter ⚠
- p.His173Arg Single submitter ⚠
- p.Ile210Leu Single submitter ⚠
- p.Ile237Met Single submitter ⚠
- p.Met182Val Single submitter ⚠
- p.Met93Thr Single submitter ⚠
- p.Phe105Leu Single submitter ⚠
- p.Phe121Val Single submitter ⚠
- p.Phe273Leu Single submitter ⚠
- p.Phe274Leu Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro154Ser Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro164Thr Single submitter ⚠
- p.Pro167Ser Single submitter ⚠
- p.Pro190Leu Single submitter ⚠
- p.Pro56Leu Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Ser250Gly Single submitter ⚠
- p.Ser40Arg Single submitter ⚠
- p.Ser92Asn Single submitter ⚠
- p.Thr264Asn Single submitter ⚠
- p.Thr78Met Single submitter ⚠
- p.Trp71Gly Single submitter ⚠
- p.Tyr19Asp Single submitter ⚠
- p.Tyr34Asp Single submitter ⚠
- p.Val104Leu Single submitter ⚠
- p.Val246Met Single submitter ⚠
- p.Val48Met Single submitter ⚠
- p.Val74Ala Single submitter ⚠