LGALS9 — 70 ClinVar variants
All ClinVar germline LGALS9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
1 Benign · 6 Likely benign · 63 Uncertain significance
Full LGALS9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LGALS9 p.Ala8Ser Uncertain significance Single submitter
- LGALS9 p.Ala8Thr Uncertain significance Single submitter
- LGALS9 p.Arg130His Uncertain significance Single submitter
- LGALS9 p.Arg151Cys Uncertain significance Single submitter
- LGALS9 p.Arg151His Uncertain significance Single submitter
- LGALS9 p.Arg175Gly Uncertain significance Single submitter
- LGALS9 p.Arg177Cys Uncertain significance Single submitter
- LGALS9 p.Arg177His Uncertain significance Single submitter
- LGALS9 p.Arg271Gly Uncertain significance Single submitter
- LGALS9 p.Arg271His Uncertain significance Single submitter
- LGALS9 p.Arg279His Uncertain significance Single submitter
- LGALS9 p.Arg296Gln Uncertain significance Single submitter
- LGALS9 p.Asn285His Uncertain significance Single submitter
- LGALS9 p.Gln206Arg Uncertain significance Single submitter
- LGALS9 p.Gln304Arg Uncertain significance Single submitter
- LGALS9 p.Glu291Lys Uncertain significance Single submitter
- LGALS9 p.Glu85Lys Uncertain significance Single submitter
- LGALS9 p.Gly138Ala Uncertain significance Single submitter
- LGALS9 p.Gly183Ser Uncertain significance Single submitter
- LGALS9 p.Gly323Asp Uncertain significance Single submitter
- LGALS9 p.Ile192Phe Uncertain significance Single submitter
- LGALS9 p.Ile197Val Uncertain significance Single submitter
- LGALS9 p.Ile213Asn Uncertain significance Single submitter
- LGALS9 p.Leu326Val Uncertain significance Single submitter
- LGALS9 p.Leu342Pro Uncertain significance Single submitter
- LGALS9 p.Met113Lys Uncertain significance Single submitter
- LGALS9 p.Met298Thr Uncertain significance Single submitter
- LGALS9 p.Pro150Ser Uncertain significance Single submitter
- LGALS9 p.Pro167Ser Uncertain significance Single submitter
- LGALS9 p.Pro189Leu Uncertain significance Single submitter
- LGALS9 p.Pro211His Uncertain significance Single submitter
- LGALS9 p.Pro215Leu Uncertain significance Single submitter
- LGALS9 p.Pro215Ser Uncertain significance Single submitter
- LGALS9 p.Pro219Ser Uncertain significance Single submitter
- LGALS9 p.Pro92Ala Uncertain significance Single submitter
- LGALS9 p.Pro98Ser Uncertain significance Single submitter
- LGALS9 p.Ser250Gly Uncertain significance Single submitter
- LGALS9 p.Ser286Phe Uncertain significance Single submitter
- LGALS9 p.Ser4Arg Uncertain significance Single submitter
- LGALS9 p.Thr193Asn Uncertain significance Single submitter
- LGALS9 p.Thr199Ser Uncertain significance Single submitter
- LGALS9 p.Thr32Ser Uncertain significance Single submitter
- LGALS9 p.Thr351Ser Uncertain significance Single submitter
- LGALS9 p.Val120Met Uncertain significance Single submitter
- LGALS9 p.Val72Glu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- LGALS9 p.Arg302His Benign Multiple submitters
- LGALS9 p.Arg125His Uncertain significance Single submitter
- LGALS9 p.Arg271Cys Uncertain significance Single submitter
- LGALS9 p.Arg302Cys Uncertain significance Single submitter
- LGALS9 p.Asn257Ser Uncertain significance Single submitter
- LGALS9 p.Gln78Pro Uncertain significance Single submitter
- LGALS9 p.Pro224Ala Uncertain significance Single submitter
- LGALS9 p.Pro224Leu Uncertain significance Single submitter
- LGALS9 p.Ser143Phe Uncertain significance Single submitter
- LGALS9 p.Ser250Ile Uncertain significance Single submitter
- LGALS9 p.Thr133Ile Uncertain significance Single submitter
- LGALS9 p.Thr161Lys Uncertain significance Single submitter
- LGALS9 p.Thr195Ile Uncertain significance Single submitter
- LGALS9 p.Val321Met Uncertain significance Single submitter
- LGALS9 p.Val72Met Uncertain significance Single submitter
All LGALS9 variants
Benign 1
- p.Arg302His Multiple submitters ⚠
Likely benign 6
- p.Ala203Thr Single submitter
- p.Arg334Lys Single submitter
- p.Asp284Asn Single submitter
- p.Glu313Asp Single submitter
- p.His220Asn Single submitter
- p.Thr161Met Single submitter
Uncertain significance 63
- p.Ala8Ser Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Arg125His Single submitter ⚠
- p.Arg130His Single submitter ⚠
- p.Arg151Cys Single submitter ⚠
- p.Arg151His Single submitter ⚠
- p.Arg175Gly Single submitter ⚠
- p.Arg177Cys Single submitter ⚠
- p.Arg177His Single submitter ⚠
- p.Arg271Cys Single submitter ⚠
- p.Arg271Gly Single submitter ⚠
- p.Arg271His Single submitter ⚠
- p.Arg279His Single submitter ⚠
- p.Arg296Gln Single submitter ⚠
- p.Arg302Cys Single submitter ⚠
- p.Arg332His Single submitter
- p.Asn257Ser Single submitter ⚠
- p.Asn285His Single submitter ⚠
- p.Gln206Arg Single submitter ⚠
- p.Gln304Arg Single submitter ⚠
- p.Gln78Pro Single submitter ⚠
- p.Glu291Lys Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Gly138Ala Single submitter ⚠
- p.Gly183Ser Single submitter ⚠
- p.Gly323Asp Single submitter ⚠
- p.Ile192Phe Single submitter ⚠
- p.Ile197Val Single submitter ⚠
- p.Ile213Asn Single submitter ⚠
- p.Leu326Val Single submitter ⚠
- p.Leu342Pro Single submitter ⚠
- p.Met113Lys Single submitter ⚠
- p.Met298Thr Single submitter ⚠
- p.Pro150Ser Single submitter ⚠
- p.Pro167Ser Single submitter ⚠
- p.Pro189Leu Single submitter ⚠
- p.Pro211His Single submitter ⚠
- p.Pro215Leu Single submitter ⚠
- p.Pro215Ser Single submitter ⚠
- p.Pro219Ser Single submitter ⚠
- p.Pro224Ala Single submitter ⚠
- p.Pro224Leu Single submitter ⚠
- p.Pro92Ala Single submitter ⚠
- p.Pro98Ser Single submitter ⚠
- p.Ser143Phe Single submitter ⚠
- p.Ser250Gly Single submitter ⚠
- p.Ser250Ile Single submitter ⚠
- p.Ser286Phe Single submitter ⚠
- p.Ser4Arg Single submitter ⚠
- p.Thr133Ile Single submitter ⚠
- p.Thr161Lys Single submitter ⚠
- p.Thr193Asn Single submitter ⚠
- p.Thr195Ile Single submitter ⚠
- p.Thr199Ser Single submitter ⚠
- p.Thr32Ser Single submitter ⚠
- p.Thr351Ser Single submitter ⚠
- p.Thr76Ala Single submitter
- p.Thr76Met Single submitter
- p.Val120Met Single submitter ⚠
- p.Val140Ala Single submitter
- p.Val321Met Single submitter ⚠
- p.Val72Glu Single submitter ⚠
- p.Val72Met Single submitter ⚠