LIPG — 230 ClinVar variants
All ClinVar germline LIPG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 115 flagged for review →
3 Conflicting · 20 Benign · 77 Likely benign · 130 Uncertain significance
Full LIPG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 115
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 3
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LIPG p.Arg224Cys Uncertain significance Multiple submitters
- LIPG p.Arg302Cys Uncertain significance Multiple submitters
- LIPG p.Arg431Cys Uncertain significance Multiple submitters
- LIPG p.Arg448His Uncertain significance Multiple submitters
- LIPG p.Arg484Gln Uncertain significance Multiple submitters
- LIPG p.Asn439Ser Uncertain significance Multiple submitters
- LIPG p.Met148Ile Uncertain significance Multiple submitters
- LIPG p.Ser48Cys Uncertain significance Multiple submitters
- LIPG p.Val257Ile Uncertain significance Multiple submitters
- LIPG p.Val278Ile Uncertain significance Multiple submitters
- LIPG p.Val45Ile Uncertain significance Multiple submitters
- LIPG p.Ala175Val Uncertain significance Single submitter
- LIPG p.Ala195Val Uncertain significance Single submitter
- LIPG p.Ala202Thr Uncertain significance Single submitter
- LIPG p.Ala277Asp Uncertain significance Single submitter
- LIPG p.Ala323Val Uncertain significance Single submitter
- LIPG p.Arg188Gln Uncertain significance Single submitter
- LIPG p.Arg224His Uncertain significance Single submitter
- LIPG p.Arg315Cys Uncertain significance Single submitter
- LIPG p.Arg389Gln Uncertain significance Single submitter
- LIPG p.Arg476Gln Uncertain significance Single submitter
- LIPG p.Arg481His Uncertain significance Single submitter
- LIPG p.Asn301Ser Uncertain significance Single submitter
- LIPG p.Asn328Lys Uncertain significance Single submitter
- LIPG p.Asp203Asn Uncertain significance Single submitter
- LIPG p.Asp214Glu Uncertain significance Single submitter
- LIPG p.Asp256Asn Uncertain significance Single submitter
- LIPG p.Asp256His Uncertain significance Single submitter
- LIPG p.Asp378Gly Uncertain significance Single submitter
- LIPG p.Cys272Arg Uncertain significance Single submitter
- LIPG p.Cys308Ser Uncertain significance Single submitter
- LIPG p.Cys77Arg Uncertain significance Single submitter
- LIPG p.Cys77Trp Uncertain significance Single submitter
- LIPG p.Gln296Arg Uncertain significance Single submitter
- LIPG p.Gln380Arg Uncertain significance Single submitter
- LIPG p.Gln380His Uncertain significance Single submitter
- LIPG p.Gln413His Uncertain significance Single submitter
- LIPG p.Glu154Lys Uncertain significance Single submitter
- LIPG p.Glu28Gln Uncertain significance Single submitter
- LIPG p.Glu403Lys Uncertain significance Single submitter
- LIPG p.Glu404Lys Uncertain significance Single submitter
- LIPG p.Glu492Lys Uncertain significance Single submitter
- LIPG p.Gly167Ser Uncertain significance Single submitter
- LIPG p.Gly231Arg Uncertain significance Single submitter
- LIPG p.Gly418Trp Uncertain significance Single submitter
- LIPG p.Gly69Ser Uncertain significance Single submitter
- LIPG p.Gly91Arg Uncertain significance Single submitter
- LIPG p.His110Tyr Uncertain significance Single submitter
- LIPG p.His173Arg Uncertain significance Single submitter
- LIPG p.His61Asp Uncertain significance Single submitter
- LIPG p.Ile204Val Uncertain significance Single submitter
- LIPG p.Ile307Met Uncertain significance Single submitter
- LIPG p.Ile386Thr Uncertain significance Single submitter
- LIPG p.Ile472Val Uncertain significance Single submitter
- LIPG p.Leu382Gln Uncertain significance Single submitter
- LIPG p.Leu410Val Uncertain significance Single submitter
- LIPG p.Leu444Arg Uncertain significance Single submitter
- LIPG p.Lys324Gln Uncertain significance Single submitter
- LIPG p.Lys37Asn Uncertain significance Single submitter
- LIPG p.Lys39Thr Uncertain significance Single submitter
- LIPG p.Met234Lys Uncertain significance Single submitter
- LIPG p.Pro125Ser Uncertain significance Single submitter
- LIPG p.Pro24Ser Uncertain significance Single submitter
- LIPG p.Pro291Leu Uncertain significance Single submitter
- LIPG p.Pro73Ser Uncertain significance Single submitter
- LIPG p.Ser471Gly Uncertain significance Single submitter
- LIPG p.Thr190Ala Uncertain significance Single submitter
- LIPG p.Thr415Ile Uncertain significance Single submitter
- LIPG p.Thr456Ser Uncertain significance Single submitter
- LIPG p.Thr461Arg Uncertain significance Single submitter
- LIPG p.Thr496Ala Uncertain significance Single submitter
- LIPG p.Thr85Ile Uncertain significance Single submitter
- LIPG p.Trp151Cys Uncertain significance Single submitter
- LIPG p.Tyr347Phe Uncertain significance Single submitter
- LIPG p.Val119Ile Uncertain significance Single submitter
- LIPG p.Val186Met Uncertain significance Single submitter
- LIPG p.Val370Ile Uncertain significance Single submitter
- LIPG p.Val68Phe Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- LIPG p.Arg112Gly Uncertain significance Multiple submitters
- LIPG p.Asn80Ser Uncertain significance Multiple submitters
- LIPG p.Gly227Ser Uncertain significance Multiple submitters
- LIPG p.Gly96Ser Uncertain significance Multiple submitters
- LIPG p.Pro210Leu Uncertain significance Multiple submitters
- LIPG p.Ala116Thr Uncertain significance Single submitter
- LIPG p.Ala134Val Uncertain significance Single submitter
- LIPG p.Ala202Asp Uncertain significance Single submitter
- LIPG p.Arg315His Uncertain significance Single submitter
- LIPG p.Arg339Gln Uncertain significance Single submitter
- LIPG p.Arg438Cys Uncertain significance Single submitter
- LIPG p.Arg450Trp Uncertain significance Single submitter
- LIPG p.Arg458Trp Uncertain significance Single submitter
- LIPG p.Arg476Trp Likely benign Single submitter
- LIPG p.Arg481Cys Uncertain significance Single submitter
- LIPG p.Arg54Cys Uncertain significance Single submitter
- LIPG p.Asn117Ser Uncertain significance Single submitter
- LIPG p.Asn393Lys Uncertain significance Single submitter
- LIPG p.Asp203Tyr Uncertain significance Single submitter
- LIPG p.Asp289Gly Uncertain significance Single submitter
- LIPG p.Glu273Asp Likely benign Single submitter
- LIPG p.Gly184Arg Uncertain significance Single submitter
- LIPG p.Gly69Ala Uncertain significance Single submitter
- LIPG p.Ile307Thr Uncertain significance Single submitter
- LIPG p.Leu165Phe Uncertain significance Single submitter
- LIPG p.Leu285Val Uncertain significance Single submitter
- LIPG p.Pro243Leu Uncertain significance Single submitter
- LIPG p.Ser159Pro Uncertain significance Single submitter
- LIPG p.Ser95Arg Uncertain significance Single submitter
- LIPG p.Thr456Ala Uncertain significance Single submitter
- LIPG p.Thr93Met Uncertain significance Single submitter
- LIPG p.Val106Met Uncertain significance Single submitter
- LIPG p.Val182Leu Uncertain significance Single submitter
- LIPG p.Val451Met Uncertain significance Single submitter
All LIPG variants
Conflicting classifications of pathogenicity 3
- p.Arg442Gln Single submitter ⚠
- p.Gly161Arg Single submitter ⚠
- p.Thr298Ile Single submitter ⚠
Benign 20
- c.1158-4G>C Multiple submitters
- c.280-16C>G Multiple submitters
- p.Asn396Ser Multiple submitters
- p.Gly26Ser Multiple submitters
- p.Ser21= Multiple submitters
- p.Ser4= Multiple submitters
- p.Thr111Ile Multiple submitters
- p.Thr298Ser Multiple submitters
- c.1157+12G>A Single submitter
- c.1376+18C>T Single submitter
- c.460-16T>C Single submitter
- c.794-16T>C Single submitter
- c.794-6C>T Single submitter
- p.Ala175= Single submitter
- p.Lys39Gln Single submitter
- p.Met361Thr Single submitter
- p.Pro210= Single submitter
- p.Pro467Ser Single submitter
- p.Pro73Leu Single submitter
- p.Val269= Single submitter
Likely benign 77
- c.1036+13C>A Single submitter
- c.1036+15C>T Single submitter
- c.1036+18G>T Single submitter
- c.1036+7T>C Single submitter
- c.1037-13G>T Single submitter
- c.1037-7A>T Single submitter
- c.1157+11C>T Single submitter
- c.1157+18C>T Single submitter
- c.1158-5T>C Single submitter
- c.1376+23_1376+25del Single submitter
- c.1376+7G>A Single submitter
- c.1481+11C>G Single submitter
- c.1481+11C>T Single submitter
- c.1481+17C>T Single submitter
- c.1482-17C>T Single submitter
- c.279+8C>T Single submitter
- c.280-17T>C Single submitter
- c.572-20G>A Single submitter
- c.572-8T>C Single submitter
- c.794-11C>T Single submitter
- c.794-4C>T Single submitter
- c.794-5C>T Single submitter
- c.97+14G>A Single submitter
- c.98-15G>A Single submitter
- c.98-6C>A Single submitter
- p.Ala134= Single submitter
- p.Ala172= Single submitter
- p.Ala178= Single submitter
- p.Ala19= Single submitter
- p.Ala195= Single submitter
- p.Ala202= Single submitter
- p.Ala262= Single submitter
- p.Arg389= Single submitter
- p.Arg442Trp Single submitter
- p.Arg476Trp Single submitter ⚠
- p.Asn255= Single submitter
- p.Asn491= Single submitter
- p.Asp115= Single submitter
- p.Asp115Glu Single submitter
- p.Asp156= Single submitter
- p.Asp211= Single submitter
- p.Asp466= Single submitter
- p.Cys463= Single submitter
- p.Gln413= Single submitter
- p.Gln436= Single submitter
- p.Glu273Asp Single submitter ⚠
- p.Glu391Lys Single submitter
- p.Glu60= Single submitter
- p.Gly201= Single submitter
- p.Gly227= Single submitter
- p.Gly374= Single submitter
- p.His173= Single submitter
- p.Ile390= Single submitter
- p.Ile97= Single submitter
- p.Leu160= Single submitter
- p.Leu170= Single submitter
- p.Leu280= Single submitter
- p.Lys428= Single submitter
- p.Lys482= Single submitter
- p.Phe226= Single submitter
- p.Phe398= Single submitter
- p.Pro291= Single submitter
- p.Pro440= Single submitter
- p.Ser12= Single submitter
- p.Ser318= Single submitter
- p.Ser379= Single submitter
- p.Ser95= Single submitter
- p.Thr223= Single submitter
- p.Thr402= Single submitter
- p.Tyr369= Single submitter
- p.Val118= Single submitter
- p.Val120= Single submitter
- p.Val23= Single submitter
- p.Val68= Single submitter
- c.572-4G>T No assertion criteria LIPG-related disorder
- c.-1G>T No assertion criteria LIPG-related disorder
- p.Gly418= No assertion criteria LIPG-related disorder
Uncertain significance 130
- p.Arg112Gly Multiple submitters ⚠
- p.Arg224Cys Multiple submitters ⚠
- p.Arg302Cys Multiple submitters ⚠
- p.Arg431Cys Multiple submitters ⚠
- p.Arg448His Multiple submitters ⚠
- p.Arg484Gln Multiple submitters ⚠
- p.Asn439Ser Multiple submitters ⚠
- p.Asn80Ser Multiple submitters ⚠
- p.Gly227Ser Multiple submitters ⚠
- p.Gly96Ser Multiple submitters ⚠
- p.Met148Ile Multiple submitters ⚠
- p.Pro210Leu Multiple submitters ⚠
- p.Ser48Cys Multiple submitters ⚠
- p.Val257Ile Multiple submitters ⚠
- p.Val278Ile Multiple submitters ⚠
- p.Val45Ile Multiple submitters ⚠
- c.1157+2T>C Single submitter
- c.1482-12G>A Single submitter
- c.1482-6T>C Single submitter
- c.460-2A>G Single submitter
- c.572-10T>C Single submitter
- c.794-1G>A Single submitter
- p.Ala116Thr Single submitter ⚠
- p.Ala134Val Single submitter ⚠
- p.Ala175Val Single submitter ⚠
- p.Ala195Val Single submitter ⚠
- p.Ala202Asp Single submitter ⚠
- p.Ala202Thr Single submitter ⚠
- p.Ala277Asp Single submitter ⚠
- p.Ala323Val Single submitter ⚠
- p.Arg188Gln Single submitter ⚠
- p.Arg188Ter Single submitter
- p.Arg207Lys Single submitter
- p.Arg224His Single submitter ⚠
- p.Arg276Ter Single submitter
- p.Arg315Cys Single submitter ⚠
- p.Arg315His Single submitter ⚠
- p.Arg339Gln Single submitter ⚠
- p.Arg389Gln Single submitter ⚠
- p.Arg438Cys Single submitter ⚠
- p.Arg448Cys Single submitter
- p.Arg450Trp Single submitter ⚠
- p.Arg458Trp Single submitter ⚠
- p.Arg476Gln Single submitter ⚠
- p.Arg481Cys Single submitter ⚠
- p.Arg481His Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Asn117Ser Single submitter ⚠
- p.Asn244fs Single submitter
- p.Asn301Ser Single submitter ⚠
- p.Asn328Lys Single submitter ⚠
- p.Asn393Lys Single submitter ⚠
- p.Asp203Asn Single submitter ⚠
- p.Asp203Tyr Single submitter ⚠
- p.Asp214Glu Single submitter ⚠
- p.Asp256Asn Single submitter ⚠
- p.Asp256His Single submitter ⚠
- p.Asp289Gly Single submitter ⚠
- p.Asp378Gly Single submitter ⚠
- p.Cys272Arg Single submitter ⚠
- p.Cys308Ser Single submitter ⚠
- p.Cys77Arg Single submitter ⚠
- p.Cys77Trp Single submitter ⚠
- p.Gln296Arg Single submitter ⚠
- p.Gln380Arg Single submitter ⚠
- p.Gln380His Single submitter ⚠
- p.Gln413His Single submitter ⚠
- p.Glu154Lys Single submitter ⚠
- p.Glu28Gln Single submitter ⚠
- p.Glu403Lys Single submitter ⚠
- p.Glu404Lys Single submitter ⚠
- p.Glu492Lys Single submitter ⚠
- p.Gly167Ser Single submitter ⚠
- p.Gly184Arg Single submitter ⚠
- p.Gly231Arg Single submitter ⚠
- p.Gly418Trp Single submitter ⚠
- p.Gly69Ala Single submitter ⚠
- p.Gly69Ser Single submitter ⚠
- p.Gly91Arg Single submitter ⚠
- p.His110Tyr Single submitter ⚠
- p.His173Arg Single submitter ⚠
- p.His354Tyr Single submitter
- p.His61Asp Single submitter ⚠
- p.Ile204Val Single submitter ⚠
- p.Ile307Met Single submitter ⚠
- p.Ile307Thr Single submitter ⚠
- p.Ile386Thr Single submitter ⚠
- p.Ile472Val Single submitter ⚠
- p.Leu126fs Single submitter
- p.Leu165Phe Single submitter ⚠
- p.Leu285fs Single submitter
- p.Leu285Val Single submitter ⚠
- p.Leu382Gln Single submitter ⚠
- p.Leu410Val Single submitter ⚠
- p.Leu444Arg Single submitter ⚠
- p.Lys324Gln Single submitter ⚠
- p.Lys37Asn Single submitter ⚠
- p.Lys39Thr Single submitter ⚠
- p.Lys84Asn Single submitter
- p.Met234Lys Single submitter ⚠
- p.Met94Ile Single submitter
- p.Pro125Ser Single submitter ⚠
- p.Pro243Leu Single submitter ⚠
- p.Pro24Ser Single submitter ⚠
- p.Pro291Leu Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Ser159Pro Single submitter ⚠
- p.Ser225Phe Single submitter
- p.Ser471Gly Single submitter ⚠
- p.Ser95Arg Single submitter ⚠
- p.Thr190Ala Single submitter ⚠
- p.Thr415Ile Single submitter ⚠
- p.Thr456Ala Single submitter ⚠
- p.Thr456Ser Single submitter ⚠
- p.Thr461Arg Single submitter ⚠
- p.Thr461fs Single submitter
- p.Thr496Ala Single submitter ⚠
- p.Thr85Ile Single submitter ⚠
- p.Thr93Met Single submitter ⚠
- p.Trp151Cys Single submitter ⚠
- p.Tyr347Phe Single submitter ⚠
- p.Val106Met Single submitter ⚠
- p.Val119Ile Single submitter ⚠
- p.Val182Leu Single submitter ⚠
- p.Val186Met Single submitter ⚠
- p.Val236Leu Single submitter
- p.Val370Ile Single submitter ⚠
- p.Val400fs Single submitter
- p.Val451Met Single submitter ⚠
- p.Val68Phe Single submitter ⚠