LMAN2 — 67 ClinVar variants
All ClinVar germline LMAN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
2 Benign · 2 Likely benign · 63 Uncertain significance
Full LMAN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LMAN2 p.Ala134Thr Uncertain significance Single submitter
- LMAN2 p.Ala44Ser Uncertain significance Single submitter
- LMAN2 p.Arg139Gln Uncertain significance Single submitter
- LMAN2 p.Arg172His Uncertain significance Single submitter
- LMAN2 p.Arg195Cys Uncertain significance Single submitter
- LMAN2 p.Arg195His Uncertain significance Single submitter
- LMAN2 p.Arg207His Uncertain significance Single submitter
- LMAN2 p.Arg209His Uncertain significance Single submitter
- LMAN2 p.Arg218Cys Uncertain significance Single submitter
- LMAN2 p.Arg314His Uncertain significance Single submitter
- LMAN2 p.Arg9His Uncertain significance Single submitter
- LMAN2 p.Asn297Thr Uncertain significance Single submitter
- LMAN2 p.Asn305Asp Uncertain significance Single submitter
- LMAN2 p.Asn352Thr Uncertain significance Single submitter
- LMAN2 p.Asp210Asn Uncertain significance Single submitter
- LMAN2 p.Asp261Asn Uncertain significance Single submitter
- LMAN2 p.Cys16Phe Uncertain significance Single submitter
- LMAN2 p.Gln78Arg Uncertain significance Single submitter
- LMAN2 p.Gly11Ser Uncertain significance Single submitter
- LMAN2 p.Gly122Ser Uncertain significance Single submitter
- LMAN2 p.Gly258Ser Uncertain significance Single submitter
- LMAN2 p.Gly316Arg Uncertain significance Single submitter
- LMAN2 p.Ile292Val Uncertain significance Single submitter
- LMAN2 p.Leu161Pro Uncertain significance Single submitter
- LMAN2 p.Leu17Val Uncertain significance Single submitter
- LMAN2 p.Leu215Val Uncertain significance Single submitter
- LMAN2 p.Leu23Phe Uncertain significance Single submitter
- LMAN2 p.Leu23Val Uncertain significance Single submitter
- LMAN2 p.Leu33Phe Uncertain significance Single submitter
- LMAN2 p.Met271Ile Uncertain significance Single submitter
- LMAN2 p.Pro106Leu Uncertain significance Single submitter
- LMAN2 p.Pro175Leu Uncertain significance Single submitter
- LMAN2 p.Pro32Ser Uncertain significance Single submitter
- LMAN2 p.Ser178Leu Uncertain significance Single submitter
- LMAN2 p.Thr213Ser Uncertain significance Single submitter
- LMAN2 p.Thr84Lys Uncertain significance Single submitter
- LMAN2 p.Trp12Arg Uncertain significance Single submitter
- LMAN2 p.Trp12Cys Uncertain significance Single submitter
- LMAN2 p.Tyr251Cys Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- LMAN2 p.Arg139Trp Uncertain significance Single submitter
- LMAN2 p.Arg209Cys Uncertain significance Single submitter
- LMAN2 p.Arg218His Uncertain significance Single submitter
- LMAN2 p.Asn208Ser Uncertain significance Single submitter
- LMAN2 p.Asp111His Uncertain significance Single submitter
- LMAN2 p.Asp308Asn Uncertain significance Single submitter
- LMAN2 p.Leu135Met Uncertain significance Single submitter
- LMAN2 p.Phe324Leu Uncertain significance Single submitter
- LMAN2 p.Pro146Thr Uncertain significance Single submitter
- LMAN2 p.Pro302Arg Uncertain significance Single submitter
- LMAN2 p.Pro92Thr Uncertain significance Single submitter
- LMAN2 p.Thr319Met Uncertain significance Single submitter
- LMAN2 p.Val323Met Uncertain significance Single submitter
- LMAN2 p.Val339Leu Uncertain significance Single submitter
All LMAN2 variants
Benign 2
- p.Ala330Thr Single submitter
- p.Leu39Ser Single submitter
Uncertain significance 63
- p.Ala134Thr Single submitter ⚠
- p.Ala200Val Single submitter
- p.Ala44Ser Single submitter ⚠
- p.Arg139Gln Single submitter ⚠
- p.Arg139Trp Single submitter ⚠
- p.Arg141Cys Single submitter
- p.Arg172His Single submitter ⚠
- p.Arg195Cys Single submitter ⚠
- p.Arg195His Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg218Cys Single submitter ⚠
- p.Arg218His Single submitter ⚠
- p.Arg314His Single submitter ⚠
- p.Arg348Trp Single submitter
- p.Arg9His Single submitter ⚠
- p.Asn208Ser Single submitter ⚠
- p.Asn297Thr Single submitter ⚠
- p.Asn305Asp Single submitter ⚠
- p.Asn352Thr Single submitter ⚠
- p.Asp111His Single submitter ⚠
- p.Asp210Asn Single submitter ⚠
- p.Asp212Asn Single submitter
- p.Asp261Asn Single submitter ⚠
- p.Asp308Asn Single submitter ⚠
- p.Asp76Ala Single submitter
- p.Cys16Phe Single submitter ⚠
- p.Gln78Arg Single submitter ⚠
- p.Gly11Ser Single submitter ⚠
- p.Gly122Ser Single submitter ⚠
- p.Gly222Asp Single submitter
- p.Gly258Ser Single submitter ⚠
- p.Gly316Arg Single submitter ⚠
- p.His117Tyr Single submitter
- p.Ile292Val Single submitter ⚠
- p.Leu135Met Single submitter ⚠
- p.Leu161Pro Single submitter ⚠
- p.Leu17Val Single submitter ⚠
- p.Leu215Val Single submitter ⚠
- p.Leu23Phe Single submitter ⚠
- p.Leu23Val Single submitter ⚠
- p.Leu33Phe Single submitter ⚠
- p.Met271Ile Single submitter ⚠
- p.Phe324Leu Single submitter ⚠
- p.Pro106Leu Single submitter ⚠
- p.Pro146Thr Single submitter ⚠
- p.Pro175Leu Single submitter ⚠
- p.Pro302Arg Single submitter ⚠
- p.Pro32Ser Single submitter ⚠
- p.Pro92Thr Single submitter ⚠
- p.Ser178Leu Single submitter ⚠
- p.Thr138Ile Single submitter
- p.Thr213Ser Single submitter ⚠
- p.Thr319Met Single submitter ⚠
- p.Thr84Lys Single submitter ⚠
- p.Trp12Arg Single submitter ⚠
- p.Trp12Cys Single submitter ⚠
- p.Tyr251Cys Single submitter ⚠
- p.Val278Ala Single submitter
- p.Val323Met Single submitter ⚠
- p.Val339Leu Single submitter ⚠
- p.Val339Met Single submitter