Sugi Variant

Sugi Variant/LRP1

LRP1 — 839 ClinVar variants

All ClinVar germline LRP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 264 flagged for review →

5 Pathogenic · 2 Likely pathogenic · 9 Conflicting · 81 Benign · 20 Benign/Likely benign · 193 Likely benign · 529 Uncertain significance

Full LRP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 264

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 4

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 208

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 208

Predictors split 51

The independent predictors disagree with each other — read with care.

All LRP1 variants

Pathogenic 5

  • c.2798-4C>A No assertion criteria developmental dysplasia of the hip 3
  • p.Arg1783Trp No assertion criteria developmental dysplasia of the hip 3 ⚠
  • p.Lys1245Arg No assertion criteria keratosis pilaris ⚠
  • p.Pro224Ala No assertion criteria developmental dysplasia of the hip 3 ⚠
  • p.Thr2129Lys No assertion criteria developmental dysplasia of the hip 3 ⚠

Likely pathogenic 2

Conflicting classifications of pathogenicity 9

Benign 81

Benign/Likely benign 20

Likely benign 193

Uncertain significance 529

Showing the top 300 by review status; the full set is in the sitemap.